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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HDX

Z-value: 0.46

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Transcription factors associated with HDX

Gene Symbol Gene ID Gene Info
HDX
ENSG00000165259.9 highly divergent homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HDXhg19_v2_chrX_-_83757399_83757487-0.671.5e-01Click!

Activity profile of HDX motif

Sorted Z-values of HDX motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_113735575 0.96 ENST00000376489.2
ENST00000259205.4
IL36G
interleukin 36, gamma
chr1_-_153363452 0.70 ENST00000368732.1
ENST00000368733.3
S100A8
S100 calcium binding protein A8
chr2_-_113594279 0.42 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
IL1B
interleukin 1, beta
chr9_+_6215799 0.36 ENST00000417746.2
ENST00000456383.2
IL33
interleukin 33
chr7_-_139756791 0.24 ENST00000489809.1
PARP12
poly (ADP-ribose) polymerase family, member 12
chr6_+_144471643 0.14 ENST00000367568.4
STX11
syntaxin 11
chr7_+_144015218 0.14 ENST00000408951.1
OR2A1
olfactory receptor, family 2, subfamily A, member 1
chrX_+_100224676 0.12 ENST00000450049.2
ARL13A
ADP-ribosylation factor-like 13A
chr14_+_71788096 0.12 ENST00000557151.1
SIPA1L1
signal-induced proliferation-associated 1 like 1
chr19_+_36602104 0.11 ENST00000585332.1
ENST00000262637.4
OVOL3
ovo-like zinc finger 3
chr5_-_135290705 0.10 ENST00000274507.1
LECT2
leukocyte cell-derived chemotaxin 2
chr1_-_209825674 0.08 ENST00000367030.3
ENST00000356082.4
LAMB3
laminin, beta 3
chr7_-_107883678 0.08 ENST00000417701.1
NRCAM
neuronal cell adhesion molecule
chr11_-_66675371 0.07 ENST00000393955.2
PC
pyruvate carboxylase
chr8_+_24151620 0.07 ENST00000437154.2
ADAM28
ADAM metallopeptidase domain 28
chr1_-_169680745 0.06 ENST00000236147.4
SELL
selectin L
chr9_+_35538616 0.06 ENST00000455600.1
RUSC2
RUN and SH3 domain containing 2
chr13_+_24144796 0.06 ENST00000403372.2
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr3_-_100565249 0.05 ENST00000495591.1
ENST00000383691.4
ENST00000466947.1
ABI3BP
ABI family, member 3 (NESH) binding protein
chr1_+_117602925 0.05 ENST00000369466.4
TTF2
transcription termination factor, RNA polymerase II
chr3_-_51533966 0.05 ENST00000504652.1
VPRBP
Vpr (HIV-1) binding protein
chr7_-_55620433 0.05 ENST00000418904.1
VOPP1
vesicular, overexpressed in cancer, prosurvival protein 1
chr12_+_101869096 0.05 ENST00000551346.1
SPIC
Spi-C transcription factor (Spi-1/PU.1 related)
chr1_+_21880560 0.05 ENST00000425315.2
ALPL
alkaline phosphatase, liver/bone/kidney
chr1_-_11024258 0.04 ENST00000418570.2
C1orf127
chromosome 1 open reading frame 127
chr14_+_79745682 0.04 ENST00000557594.1
NRXN3
neurexin 3
chr5_-_135290651 0.04 ENST00000522943.1
ENST00000514447.2
LECT2
leukocyte cell-derived chemotaxin 2
chrX_+_27608490 0.04 ENST00000451261.2
DCAF8L2
DDB1 and CUL4 associated factor 8-like 2
chr1_+_197237352 0.03 ENST00000538660.1
ENST00000367400.3
ENST00000367399.2
CRB1
crumbs homolog 1 (Drosophila)
chr12_-_39734783 0.03 ENST00000552961.1
KIF21A
kinesin family member 21A
chr12_+_10460417 0.03 ENST00000381908.3
ENST00000336164.4
ENST00000350274.5
KLRD1
killer cell lectin-like receptor subfamily D, member 1
chr15_-_54025300 0.03 ENST00000559418.1
WDR72
WD repeat domain 72
chr10_-_14372870 0.03 ENST00000357447.2
FRMD4A
FERM domain containing 4A
chrX_+_55649833 0.03 ENST00000339140.3
FOXR2
forkhead box R2
chr13_+_24144509 0.02 ENST00000248484.4
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr3_+_54157480 0.02 ENST00000490478.1
CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr5_-_35230771 0.02 ENST00000342362.5
PRLR
prolactin receptor
chr2_+_128403439 0.02 ENST00000544369.1
GPR17
G protein-coupled receptor 17
chr8_+_110098850 0.02 ENST00000518632.1
TRHR
thyrotropin-releasing hormone receptor
chr7_+_99954224 0.02 ENST00000608825.1
PILRB
paired immunoglobin-like type 2 receptor beta
chr7_-_121944491 0.01 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZF1
FEZ family zinc finger 1
chr7_-_135412925 0.01 ENST00000354042.4
SLC13A4
solute carrier family 13 (sodium/sulfate symporter), member 4
chr14_+_79745746 0.00 ENST00000281127.7
NRXN3
neurexin 3
chr18_-_53804580 0.00 ENST00000590484.1
ENST00000589293.1
ENST00000587904.1
ENST00000591974.1
RP11-456O19.4
RP11-456O19.4

Network of associatons between targets according to the STRING database.

First level regulatory network of HDX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0031622 regulation of fever generation(GO:0031620) positive regulation of fever generation(GO:0031622)
0.1 0.7 GO:0032119 sequestering of zinc ion(GO:0032119)
0.0 0.4 GO:0051025 negative regulation of immunoglobulin secretion(GO:0051025)
0.0 0.1 GO:0019074 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.0 0.0 GO:0071529 cementum mineralization(GO:0071529)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.1 1.4 GO:0005149 interleukin-1 receptor binding(GO:0005149)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling