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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for GRHL1

Z-value: 0.30

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Transcription factors associated with GRHL1

Gene Symbol Gene ID Gene Info
GRHL1
ENSG00000134317.13 GRHL1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GRHL1hg19_v2_chr2_+_10091783_100918110.128.3e-01Click!

Activity profile of GRHL1 motif

Sorted Z-values of GRHL1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GRHL1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr1_-_153113927 0.29 ENST00000368752.4
 SPRR2B
 small proline-rich protein 2B
chr14_-_62217779 0.14 ENST00000554254.1
 HIF1A-AS2
 HIF1A antisense RNA 2
chr19_+_45312310 0.13 ENST00000589651.1
 BCAM
 basal cell adhesion molecule (Lutheran blood group)
chr20_-_18038521 0.11 ENST00000278780.6
 OVOL2
 ovo-like zinc finger 2
chr3_+_101568349 0.10 ENST00000326151.5
ENST00000326172.5
 NFKBIZ
 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr1_-_234667504 0.10 ENST00000421207.1
ENST00000435574.1
 RP5-855F14.1
 RP5-855F14.1
chr5_+_134303591 0.09 ENST00000282611.6
 CATSPER3
 cation channel, sperm associated 3
chr19_+_45312347 0.09 ENST00000270233.6
ENST00000591520.1
 BCAM
 basal cell adhesion molecule (Lutheran blood group)
chr1_+_206643806 0.08 ENST00000537984.1
 IKBKE
 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr4_+_26859300 0.08 ENST00000494628.2
 STIM2
 stromal interaction molecule 2
chr7_+_76139925 0.08 ENST00000394849.1
 UPK3B
 uroplakin 3B
chr11_-_93583697 0.07 ENST00000409977.1
 VSTM5
 V-set and transmembrane domain containing 5
chr22_+_18560743 0.07 ENST00000399744.3
 PEX26
 peroxisomal biogenesis factor 26
chr19_-_12405689 0.07 ENST00000355684.5
 ZNF44
 zinc finger protein 44
chr6_-_31107127 0.07 ENST00000259845.4
 PSORS1C2
 psoriasis susceptibility 1 candidate 2
chr6_-_43027105 0.06 ENST00000230413.5
ENST00000487429.1
ENST00000489623.1
ENST00000468957.1
 MRPL2
 mitochondrial ribosomal protein L2
chr7_+_76139833 0.06 ENST00000257632.5
 UPK3B
 uroplakin 3B
chr21_+_33671264 0.06 ENST00000339944.4
 MRAP
 melanocortin 2 receptor accessory protein
chr3_-_58643458 0.06 ENST00000498347.1
 FAM3D
 family with sequence similarity 3, member D
chr19_-_4043154 0.05 ENST00000535853.1
 AC016586.1
 AC016586.1
chr11_-_67442196 0.05 ENST00000525827.1
 ALDH3B2
 aldehyde dehydrogenase 3 family, member B2
chr19_-_12405606 0.04 ENST00000356109.5
 ZNF44
 zinc finger protein 44
chr14_-_23540747 0.04 ENST00000555566.1
ENST00000338631.6
ENST00000557515.1
ENST00000397341.3
 ACIN1
 apoptotic chromatin condensation inducer 1
chr9_+_140122018 0.04 ENST00000445101.2
 RNF224
 ring finger protein 224
chr2_+_95940220 0.04 ENST00000542147.1
 PROM2
 prominin 2
chr1_+_44440575 0.04 ENST00000532642.1
ENST00000236067.4
ENST00000471859.2
 ATP6V0B
 ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
chr18_-_35145981 0.04 ENST00000420428.2
ENST00000412753.1
 CELF4
 CUGBP, Elav-like family member 4
chr14_-_23540826 0.04 ENST00000357481.2
 ACIN1
 apoptotic chromatin condensation inducer 1
chr1_+_206643787 0.04 ENST00000367120.3
 IKBKE
 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr5_+_125759140 0.03 ENST00000543198.1
 GRAMD3
 GRAM domain containing 3
chr19_-_35981358 0.03 ENST00000484218.2
ENST00000338897.3
 KRTDAP
 keratinocyte differentiation-associated protein
chr4_-_129209944 0.03 ENST00000520121.1
 PGRMC2
 progesterone receptor membrane component 2
chr19_+_19496728 0.03 ENST00000537887.1
ENST00000417582.2
 GATAD2A
 GATA zinc finger domain containing 2A
chr16_+_2564254 0.03 ENST00000565223.1
 ATP6V0C
 ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
chr1_-_24469602 0.03 ENST00000270800.1
 IL22RA1
 interleukin 22 receptor, alpha 1
chr14_-_80677815 0.03 ENST00000557125.1
ENST00000555750.1
 DIO2
 deiodinase, iodothyronine, type II
chr4_+_110736659 0.03 ENST00000394631.3
ENST00000226796.6
 GAR1
 GAR1 ribonucleoprotein
chr19_+_10736183 0.03 ENST00000590857.1
ENST00000588688.1
ENST00000586078.1
 SLC44A2
 solute carrier family 44 (choline transporter), member 2
chr19_+_1491144 0.03 ENST00000233596.3
 REEP6
 receptor accessory protein 6
chr2_+_113816215 0.03 ENST00000346807.3
 IL36RN
 interleukin 36 receptor antagonist
chr17_-_60883993 0.02 ENST00000583803.1
ENST00000456609.2
 MARCH10
 membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chr11_+_119039414 0.02 ENST00000409991.1
ENST00000292199.2
ENST00000409265.4
ENST00000409109.1
 NLRX1
 NLR family member X1
chr11_-_111636772 0.02 ENST00000531373.1
 PPP2R1B
 protein phosphatase 2, regulatory subunit A, beta
chr1_+_155023757 0.02 ENST00000356955.2
ENST00000449910.2
ENST00000359280.4
ENST00000360674.4
ENST00000368412.3
ENST00000355956.2
ENST00000368410.2
ENST00000271836.6
ENST00000368413.1
ENST00000531455.1
ENST00000447332.3
 ADAM15
 ADAM metallopeptidase domain 15
chr11_+_706595 0.02 ENST00000531348.1
ENST00000530636.1
 EPS8L2
 EPS8-like 2
chr4_-_69083720 0.02 ENST00000432593.3
 TMPRSS11BNL
 TMPRSS11B N-terminal like
chr13_+_48807288 0.02 ENST00000378565.5
 ITM2B
 integral membrane protein 2B
chr8_+_144821557 0.02 ENST00000534398.1
 FAM83H-AS1
 FAM83H antisense RNA 1 (head to head)
chr4_-_68995571 0.02 ENST00000356291.2
 TMPRSS11F
 transmembrane protease, serine 11F
chr7_+_76139741 0.02 ENST00000334348.3
ENST00000419923.2
ENST00000448265.3
ENST00000443097.2
 UPK3B
 uroplakin 3B
chr9_+_130565487 0.02 ENST00000373225.3
ENST00000431857.1
 FPGS
 folylpolyglutamate synthase
chr10_+_81838411 0.02 ENST00000372281.3
ENST00000372277.3
ENST00000372275.1
ENST00000372274.1
 TMEM254
 transmembrane protein 254
chr2_-_85641162 0.02 ENST00000447219.2
ENST00000409670.1
ENST00000409724.1
 CAPG
 capping protein (actin filament), gelsolin-like
chr14_-_80677613 0.02 ENST00000556811.1
 DIO2
 deiodinase, iodothyronine, type II
chr9_+_71736177 0.01 ENST00000606364.1
ENST00000453658.2
 TJP2
 tight junction protein 2
chr19_+_19496624 0.01 ENST00000494516.2
ENST00000360315.3
ENST00000252577.5
 GATAD2A
 GATA zinc finger domain containing 2A
chr9_+_104161123 0.01 ENST00000374861.3
ENST00000339664.2
ENST00000259395.4
 ZNF189
 zinc finger protein 189
chr2_+_95940186 0.01 ENST00000403131.2
ENST00000317668.4
ENST00000317620.9
 PROM2
 prominin 2
chr1_-_52520828 0.01 ENST00000610127.1
 TXNDC12
 thioredoxin domain containing 12 (endoplasmic reticulum)
chr19_-_291133 0.01 ENST00000327790.3
 PPAP2C
 phosphatidic acid phosphatase type 2C
chr12_+_56498312 0.01 ENST00000552766.1
 PA2G4
 proliferation-associated 2G4, 38kDa
chr11_+_119038897 0.01 ENST00000454811.1
ENST00000449394.1
 NLRX1
 NLR family member X1
chr7_-_29152509 0.01 ENST00000448959.1
 CPVL
 carboxypeptidase, vitellogenic-like
chr1_+_244515930 0.01 ENST00000366537.1
ENST00000308105.4
 C1orf100
 chromosome 1 open reading frame 100
chr5_-_132299290 0.01 ENST00000378595.3
 AFF4
 AF4/FMR2 family, member 4
chr11_+_119039069 0.01 ENST00000422249.1
 NLRX1
 NLR family member X1
chr14_+_23938891 0.01 ENST00000408901.3
ENST00000397154.3
ENST00000555128.1
 NGDN
 neuroguidin, EIF4E binding protein
chr1_-_16539094 0.01 ENST00000270747.3
 ARHGEF19
 Rho guanine nucleotide exchange factor (GEF) 19
chr9_+_130565568 0.01 ENST00000423577.1
 FPGS
 folylpolyglutamate synthase
chr19_-_14945933 0.01 ENST00000322301.3
 OR7A5
 olfactory receptor, family 7, subfamily A, member 5
chr16_-_23568651 0.01 ENST00000563232.1
ENST00000563459.1
ENST00000449606.1
 EARS2
 glutamyl-tRNA synthetase 2, mitochondrial
chr8_+_27950619 0.01 ENST00000542181.1
ENST00000524103.1
ENST00000537665.1
ENST00000380353.4
ENST00000520288.1
 ELP3
 elongator acetyltransferase complex subunit 3
chr5_-_132299313 0.01 ENST00000265343.5
 AFF4
 AF4/FMR2 family, member 4
chr19_-_17356697 0.01 ENST00000291442.3
 NR2F6
 nuclear receptor subfamily 2, group F, member 6
chr1_+_35247859 0.01 ENST00000373362.3
 GJB3
 gap junction protein, beta 3, 31kDa
chr18_-_35145728 0.01 ENST00000361795.5
ENST00000603232.1
 CELF4
 CUGBP, Elav-like family member 4
chr12_+_18414446 0.00 ENST00000433979.1
 PIK3C2G
 phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
chr4_+_156588249 0.00 ENST00000393832.3
 GUCY1A3
 guanylate cyclase 1, soluble, alpha 3
chr1_-_36863481 0.00 ENST00000315732.2
 LSM10
 LSM10, U7 small nuclear RNA associated
chr22_+_18560675 0.00 ENST00000329627.7
 PEX26
 peroxisomal biogenesis factor 26
chrX_+_146993449 0.00 ENST00000218200.8
ENST00000370471.3
ENST00000370477.1
 FMR1
 fragile X mental retardation 1
chr19_-_12146483 0.00 ENST00000455504.2
ENST00000547560.1
ENST00000552904.1
ENST00000419886.2
ENST00000550507.1
ENST00000344980.6
ENST00000550745.1
ENST00000411841.1
 ZNF433
 zinc finger protein 433
chr12_+_118814185 0.00 ENST00000543473.1
 SUDS3
 suppressor of defective silencing 3 homolog (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0060214 endocardium formation(GO:0060214)
0.0 0.1 GO:2001287 negative regulation of caveolin-mediated endocytosis(GO:2001287)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0044393 microspike(GO:0044393)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0005055 laminin receptor activity(GO:0005055)
0.0 0.1 GO:0008384 IkappaB kinase activity(GO:0008384) K48-linked polyubiquitin binding(GO:0036435)
0.0 0.1 GO:0031783 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783)