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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for GMEB2
Z-value: 2.25
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Transcription factors associated with GMEB2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GMEB2 | hg19_v2_chr20_-_62258394_62258464 | -0.40 | 4.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of GMEB2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.3 | GO:0046324 | regulation of glucose import(GO:0046324) |
| 0.1 | 2.7 | GO:0005981 | regulation of glycogen catabolic process(GO:0005981) |
| 0.3 | 2.5 | GO:1902035 | positive regulation of hematopoietic stem cell proliferation(GO:1902035) |
| 0.0 | 2.4 | GO:0006911 | phagocytosis, engulfment(GO:0006911) |
| 0.0 | 2.2 | GO:0000724 | double-strand break repair via homologous recombination(GO:0000724) |
| 0.0 | 2.1 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.1 | 2.0 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.1 | 1.9 | GO:0050942 | positive regulation of pigment cell differentiation(GO:0050942) |
| 0.3 | 1.8 | GO:0006041 | glucosamine metabolic process(GO:0006041) |
| 0.1 | 1.8 | GO:0034587 | piRNA metabolic process(GO:0034587) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.2 | 2.7 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.0 | 2.7 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.6 | 2.2 | GO:0097196 | Shu complex(GO:0097196) |
| 0.2 | 2.0 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.0 | 1.8 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.1 | 1.6 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.2 | 1.3 | GO:0000942 | condensed nuclear chromosome outer kinetochore(GO:0000942) |
| 0.0 | 1.2 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.0 | 1.2 | GO:0031304 | intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.4 | GO:0008080 | N-acetyltransferase activity(GO:0008080) |
| 0.5 | 2.7 | GO:0050115 | myosin-light-chain-phosphatase activity(GO:0050115) |
| 0.1 | 2.5 | GO:0043422 | protein kinase B binding(GO:0043422) |
| 0.0 | 2.5 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.0 | 2.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 2.1 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 0.1 | 1.9 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.1 | 1.8 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.0 | 1.7 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 1.5 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.9 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 2.5 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 2.4 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.1 | 1.9 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 1.7 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 1.4 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 1.2 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 1.0 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 1.0 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 1.0 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.7 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 2.3 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.1 | 2.3 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.0 | 2.3 | REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.1 | 1.8 | REACTOME INTEGRATION OF PROVIRUS | Genes involved in Integration of provirus |
| 0.1 | 1.6 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.0 | 1.6 | REACTOME G2 M CHECKPOINTS | Genes involved in G2/M Checkpoints |
| 0.0 | 1.6 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 1.5 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.1 | 1.3 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |