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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for GLIS2

Z-value: 1.31

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Transcription factors associated with GLIS2

Gene Symbol Gene ID Gene Info
GLIS2
ENSG00000126603.4 GLIS family zinc finger 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GLIS2hg19_v2_chr16_+_4382225_43822250.786.8e-02Click!

Activity profile of GLIS2 motif

Sorted Z-values of GLIS2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_44637526 1.20 ENST00000372330.3
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr11_+_844067 1.16 ENST00000397406.1
ENST00000409543.2
ENST00000525201.1
TSPAN4
tetraspanin 4
chr12_-_53242770 0.93 ENST00000304620.4
ENST00000547110.1
KRT78
keratin 78
chr22_+_23264766 0.73 ENST00000390331.2
IGLC7
immunoglobulin lambda constant 7
chr5_-_176836577 0.71 ENST00000253496.3
F12
coagulation factor XII (Hageman factor)
chr22_-_50699972 0.71 ENST00000395778.3
MAPK12
mitogen-activated protein kinase 12
chr2_+_89952792 0.69 ENST00000390265.2
IGKV1D-33
immunoglobulin kappa variable 1D-33
chr7_+_150758642 0.69 ENST00000488420.1
SLC4A2
solute carrier family 4 (anion exchanger), member 2
chr12_-_120907374 0.67 ENST00000550458.1
SRSF9
serine/arginine-rich splicing factor 9
chr19_+_45254529 0.67 ENST00000444487.1
BCL3
B-cell CLL/lymphoma 3
chr7_-_130080681 0.59 ENST00000469826.1
CEP41
centrosomal protein 41kDa
chr12_+_57998595 0.58 ENST00000337737.3
ENST00000548198.1
ENST00000551632.1
DTX3
deltex homolog 3 (Drosophila)
chr6_+_131571535 0.57 ENST00000474850.2
AKAP7
A kinase (PRKA) anchor protein 7
chr5_+_172484377 0.57 ENST00000523161.1
CREBRF
CREB3 regulatory factor
chr19_+_45417504 0.57 ENST00000588750.1
ENST00000588802.1
APOC1
apolipoprotein C-I
chr19_-_42931567 0.53 ENST00000244289.4
LIPE
lipase, hormone-sensitive
chr11_-_615942 0.52 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
IRF7
interferon regulatory factor 7
chr11_+_66624527 0.51 ENST00000393952.3
LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr7_-_73133959 0.51 ENST00000395155.3
ENST00000395154.3
ENST00000222812.3
ENST00000395156.3
STX1A
syntaxin 1A (brain)
chr2_+_37571717 0.49 ENST00000338415.3
ENST00000404976.1
QPCT
glutaminyl-peptide cyclotransferase
chr14_+_105559784 0.49 ENST00000548104.1
RP11-44N21.1
RP11-44N21.1
chr2_+_114737472 0.48 ENST00000420161.1
AC110769.3
AC110769.3
chr11_-_795400 0.47 ENST00000526152.1
ENST00000456706.2
ENST00000528936.1
SLC25A22
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr7_+_2685164 0.47 ENST00000400376.2
TTYH3
tweety family member 3
chr19_-_19249255 0.47 ENST00000587583.2
ENST00000450333.2
ENST00000587096.1
ENST00000162044.9
ENST00000592369.1
ENST00000587915.1
TMEM161A
transmembrane protein 161A
chr7_+_76101379 0.46 ENST00000429179.1
DTX2
deltex homolog 2 (Drosophila)
chr19_-_17414179 0.46 ENST00000594194.1
ENST00000247706.3
ABHD8
abhydrolase domain containing 8
chr19_-_36643329 0.44 ENST00000589154.1
COX7A1
cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
chr19_+_17970693 0.43 ENST00000600147.1
ENST00000599898.1
RPL18A
ribosomal protein L18a
chrX_-_153744434 0.42 ENST00000369643.1
ENST00000393572.1
FAM3A
family with sequence similarity 3, member A
chr17_-_79481666 0.42 ENST00000575659.1
ACTG1
actin, gamma 1
chr11_-_1619524 0.41 ENST00000412090.1
KRTAP5-2
keratin associated protein 5-2
chr19_+_17970677 0.40 ENST00000222247.5
RPL18A
ribosomal protein L18a
chr11_-_615570 0.39 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
IRF7
interferon regulatory factor 7
chr14_-_105635090 0.39 ENST00000331782.3
ENST00000347004.2
JAG2
jagged 2
chr7_+_99746514 0.38 ENST00000341942.5
ENST00000441173.1
LAMTOR4
late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
chr11_+_86748957 0.37 ENST00000526733.1
ENST00000532959.1
TMEM135
transmembrane protein 135
chr19_+_41103063 0.36 ENST00000308370.7
LTBP4
latent transforming growth factor beta binding protein 4
chr7_+_2671663 0.36 ENST00000407643.1
TTYH3
tweety family member 3
chr7_+_2695726 0.36 ENST00000429448.1
TTYH3
tweety family member 3
chr19_-_8408139 0.34 ENST00000330915.3
ENST00000593649.1
ENST00000595639.1
KANK3
KN motif and ankyrin repeat domains 3
chr11_-_795286 0.34 ENST00000533385.1
ENST00000527723.1
SLC25A22
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr1_-_22215192 0.34 ENST00000374673.3
HSPG2
heparan sulfate proteoglycan 2
chr1_-_153348067 0.34 ENST00000368737.3
S100A12
S100 calcium binding protein A12
chr8_+_38243821 0.33 ENST00000519476.2
LETM2
leucine zipper-EF-hand containing transmembrane protein 2
chr22_-_39640756 0.33 ENST00000331163.6
PDGFB
platelet-derived growth factor beta polypeptide
chr19_+_45349432 0.33 ENST00000252485.4
PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr19_+_54369434 0.33 ENST00000421337.1
MYADM
myeloid-associated differentiation marker
chr17_+_41158742 0.32 ENST00000415816.2
ENST00000438323.2
IFI35
interferon-induced protein 35
chr1_-_6550625 0.32 ENST00000377725.1
ENST00000340850.5
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr19_+_3506261 0.32 ENST00000441788.2
FZR1
fizzy/cell division cycle 20 related 1 (Drosophila)
chr20_-_62203808 0.32 ENST00000467148.1
HELZ2
helicase with zinc finger 2, transcriptional coactivator
chr14_+_101293687 0.32 ENST00000455286.1
MEG3
maternally expressed 3 (non-protein coding)
chr19_-_9938480 0.32 ENST00000585379.1
FBXL12
F-box and leucine-rich repeat protein 12
chr1_+_17866290 0.31 ENST00000361221.3
ENST00000452522.1
ENST00000434513.1
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr19_+_39926791 0.31 ENST00000594990.1
SUPT5H
suppressor of Ty 5 homolog (S. cerevisiae)
chr16_+_765092 0.31 ENST00000568223.2
METRN
meteorin, glial cell differentiation regulator
chr22_-_50700140 0.31 ENST00000215659.8
MAPK12
mitogen-activated protein kinase 12
chr7_+_100271446 0.31 ENST00000419828.1
ENST00000427895.1
GNB2
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr19_-_6720686 0.30 ENST00000245907.6
C3
complement component 3
chr19_+_3185910 0.30 ENST00000588428.1
NCLN
nicalin
chr11_+_64851729 0.30 ENST00000526791.1
ENST00000526945.1
ZFPL1
zinc finger protein-like 1
chrX_-_153744507 0.30 ENST00000442929.1
ENST00000426266.1
ENST00000359889.5
ENST00000369641.3
ENST00000447601.2
ENST00000434658.2
FAM3A
family with sequence similarity 3, member A
chr5_+_667759 0.29 ENST00000594226.1
AC026740.1
Uncharacterized protein
chr2_+_37571845 0.29 ENST00000537448.1
QPCT
glutaminyl-peptide cyclotransferase
chr9_+_139839686 0.29 ENST00000371634.2
C8G
complement component 8, gamma polypeptide
chr17_-_7120525 0.28 ENST00000447163.1
ENST00000399506.2
ENST00000302955.6
DLG4
discs, large homolog 4 (Drosophila)
chr19_+_49661079 0.28 ENST00000355712.5
TRPM4
transient receptor potential cation channel, subfamily M, member 4
chr11_+_86748998 0.28 ENST00000525018.1
ENST00000355734.4
TMEM135
transmembrane protein 135
chr11_+_393428 0.27 ENST00000533249.1
ENST00000527442.1
PKP3
plakophilin 3
chr11_+_68451943 0.27 ENST00000265643.3
GAL
galanin/GMAP prepropeptide
chr16_-_18441131 0.27 ENST00000339303.5
NPIPA8
nuclear pore complex interacting protein family, member A8
chr19_+_45417921 0.27 ENST00000252491.4
ENST00000592885.1
ENST00000589781.1
APOC1
apolipoprotein C-I
chr11_-_796197 0.27 ENST00000530360.1
ENST00000528606.1
ENST00000320230.5
SLC25A22
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr3_+_127872265 0.27 ENST00000254730.6
ENST00000483457.1
EEFSEC
eukaryotic elongation factor, selenocysteine-tRNA-specific
chr5_-_159739483 0.26 ENST00000519673.1
ENST00000541762.1
CCNJL
cyclin J-like
chr17_-_18907463 0.26 ENST00000585154.2
ENST00000345041.4
FAM83G
family with sequence similarity 83, member G
chr1_-_19229248 0.26 ENST00000375341.3
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr1_-_139379 0.26 ENST00000423372.3
AL627309.1
Uncharacterized protein
chr19_+_38397839 0.26 ENST00000222345.6
SIPA1L3
signal-induced proliferation-associated 1 like 3
chr15_+_75498739 0.26 ENST00000565074.1
C15orf39
chromosome 15 open reading frame 39
chr2_-_219154715 0.26 ENST00000451181.1
ENST00000429501.1
TMBIM1
transmembrane BAX inhibitor motif containing 1
chr11_-_64646086 0.26 ENST00000320631.3
EHD1
EH-domain containing 1
chr16_+_640201 0.25 ENST00000563109.1
RAB40C
RAB40C, member RAS oncogene family
chr19_+_45251804 0.25 ENST00000164227.5
BCL3
B-cell CLL/lymphoma 3
chr19_+_45349630 0.25 ENST00000252483.5
PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chrX_-_153602991 0.25 ENST00000369850.3
ENST00000422373.1
FLNA
filamin A, alpha
chr19_-_4902877 0.25 ENST00000381781.2
ARRDC5
arrestin domain containing 5
chr16_+_811073 0.25 ENST00000382862.3
ENST00000563651.1
MSLN
mesothelin
chr19_-_19006920 0.25 ENST00000429504.2
ENST00000427170.2
CERS1
ceramide synthase 1
chr9_+_131903916 0.25 ENST00000419582.1
PPP2R4
protein phosphatase 2A activator, regulatory subunit 4
chr22_-_38484922 0.25 ENST00000428572.1
BAIAP2L2
BAI1-associated protein 2-like 2
chr11_-_118789613 0.25 ENST00000532899.1
BCL9L
B-cell CLL/lymphoma 9-like
chr12_-_106480587 0.25 ENST00000548902.1
NUAK1
NUAK family, SNF1-like kinase, 1
chr16_-_4664860 0.24 ENST00000587615.1
ENST00000587649.1
ENST00000590965.1
ENST00000591401.1
ENST00000283474.7
UBALD1
UBA-like domain containing 1
chr9_+_131904295 0.24 ENST00000434095.1
PPP2R4
protein phosphatase 2A activator, regulatory subunit 4
chr12_+_57854274 0.24 ENST00000528432.1
GLI1
GLI family zinc finger 1
chr3_-_48470838 0.24 ENST00000358459.4
ENST00000358536.4
PLXNB1
plexin B1
chr10_+_134232503 0.24 ENST00000428814.1
RP11-432J24.2
RP11-432J24.2
chr19_+_49660997 0.23 ENST00000598691.1
ENST00000252826.5
TRPM4
transient receptor potential cation channel, subfamily M, member 4
chr19_+_17858509 0.23 ENST00000594202.1
ENST00000252771.7
ENST00000389133.4
FCHO1
FCH domain only 1
chr10_-_102747190 0.23 ENST00000448244.1
ENST00000370241.3
ENST00000370236.1
ENST00000370234.4
ENST00000299179.5
ENST00000318325.2
ENST00000370242.4
ENST00000342071.1
ENST00000318364.8
ENST00000477279.1
MRPL43
mitochondrial ribosomal protein L43
chr19_+_49622646 0.23 ENST00000334186.4
PPFIA3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr19_-_36236292 0.23 ENST00000378975.3
ENST00000412391.2
ENST00000292879.5
U2AF1L4
U2 small nuclear RNA auxiliary factor 1-like 4
chr17_+_79953310 0.23 ENST00000582355.2
ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr9_+_131904233 0.23 ENST00000432651.1
ENST00000435132.1
PPP2R4
protein phosphatase 2A activator, regulatory subunit 4
chr17_+_6939362 0.23 ENST00000308027.6
SLC16A13
solute carrier family 16, member 13
chr9_+_97766469 0.23 ENST00000433691.2
C9orf3
chromosome 9 open reading frame 3
chr11_+_832804 0.23 ENST00000397420.3
ENST00000525718.1
CD151
CD151 molecule (Raph blood group)
chr22_-_19974616 0.22 ENST00000344269.3
ENST00000401994.1
ENST00000406522.1
ARVCF
armadillo repeat gene deleted in velocardiofacial syndrome
chr1_+_2487800 0.22 ENST00000355716.4
TNFRSF14
tumor necrosis factor receptor superfamily, member 14
chr22_+_31160239 0.22 ENST00000445781.1
ENST00000401475.1
OSBP2
oxysterol binding protein 2
chr2_+_220492373 0.22 ENST00000317151.3
SLC4A3
solute carrier family 4 (anion exchanger), member 3
chr19_+_56159509 0.22 ENST00000586790.1
ENST00000591578.1
ENST00000588740.1
CCDC106
coiled-coil domain containing 106
chr19_+_45417812 0.21 ENST00000592535.1
APOC1
apolipoprotein C-I
chr6_-_32908765 0.21 ENST00000416244.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr20_-_30310797 0.21 ENST00000422920.1
BCL2L1
BCL2-like 1
chr17_+_78075361 0.21 ENST00000577106.1
ENST00000390015.3
GAA
glucosidase, alpha; acid
chr19_+_58111241 0.21 ENST00000597700.1
ENST00000332854.6
ENST00000597864.1
ZNF530
zinc finger protein 530
chr19_+_10362882 0.21 ENST00000393733.2
ENST00000588502.1
MRPL4
mitochondrial ribosomal protein L4
chr19_-_2050852 0.21 ENST00000541165.1
ENST00000591601.1
MKNK2
MAP kinase interacting serine/threonine kinase 2
chr16_+_84224740 0.21 ENST00000268624.3
ADAD2
adenosine deaminase domain containing 2
chr22_-_18257178 0.20 ENST00000342111.5
BID
BH3 interacting domain death agonist
chr16_-_29934558 0.20 ENST00000568995.1
ENST00000566413.1
KCTD13
potassium channel tetramerization domain containing 13
chr22_-_21482352 0.20 ENST00000329949.3
POM121L7
POM121 transmembrane nucleoporin-like 7
chr19_-_10444188 0.20 ENST00000293677.6
RAVER1
ribonucleoprotein, PTB-binding 1
chr11_+_64851666 0.20 ENST00000525509.1
ENST00000294258.3
ENST00000526334.1
ZFPL1
zinc finger protein-like 1
chr11_+_3968573 0.20 ENST00000532990.1
STIM1
stromal interaction molecule 1
chr19_+_11200038 0.20 ENST00000558518.1
ENST00000557933.1
ENST00000455727.2
ENST00000535915.1
ENST00000545707.1
ENST00000558013.1
LDLR
low density lipoprotein receptor
chr19_+_56186557 0.19 ENST00000270460.6
EPN1
epsin 1
chr19_-_41196534 0.19 ENST00000252891.4
NUMBL
numb homolog (Drosophila)-like
chr1_-_1356628 0.19 ENST00000442470.1
ENST00000537107.1
ANKRD65
ankyrin repeat domain 65
chrX_+_118108571 0.19 ENST00000304778.7
LONRF3
LON peptidase N-terminal domain and ring finger 3
chr16_+_30087288 0.19 ENST00000279387.7
ENST00000562664.1
ENST00000562222.1
PPP4C
protein phosphatase 4, catalytic subunit
chr10_+_103825080 0.19 ENST00000299238.5
HPS6
Hermansky-Pudlak syndrome 6
chr9_+_139839711 0.18 ENST00000224181.3
C8G
complement component 8, gamma polypeptide
chr22_+_21771656 0.18 ENST00000407464.2
HIC2
hypermethylated in cancer 2
chr13_+_110959598 0.18 ENST00000360467.5
COL4A2
collagen, type IV, alpha 2
chrX_+_53449887 0.18 ENST00000375327.3
RIBC1
RIB43A domain with coiled-coils 1
chr19_+_3539152 0.18 ENST00000329493.5
C19orf71
chromosome 19 open reading frame 71
chr4_-_111120334 0.18 ENST00000503885.1
ELOVL6
ELOVL fatty acid elongase 6
chr19_-_18653781 0.18 ENST00000596558.2
ENST00000453489.2
FKBP8
FK506 binding protein 8, 38kDa
chr22_-_46931191 0.18 ENST00000454637.1
CELSR1
cadherin, EGF LAG seven-pass G-type receptor 1
chr12_+_122242597 0.18 ENST00000267197.5
SETD1B
SET domain containing 1B
chr16_-_29910365 0.17 ENST00000346932.5
ENST00000350527.3
ENST00000537485.1
ENST00000568380.1
SEZ6L2
seizure related 6 homolog (mouse)-like 2
chr19_+_56159421 0.17 ENST00000587213.1
CCDC106
coiled-coil domain containing 106
chr16_-_89752965 0.17 ENST00000567544.1
RP11-368I7.4
Uncharacterized protein
chr16_-_2031464 0.17 ENST00000356120.4
ENST00000354249.4
NOXO1
NADPH oxidase organizer 1
chr9_+_117373486 0.17 ENST00000288502.4
ENST00000374049.4
C9orf91
chromosome 9 open reading frame 91
chrX_-_153237258 0.17 ENST00000310441.7
HCFC1
host cell factor C1 (VP16-accessory protein)
chr9_-_34637806 0.16 ENST00000477726.1
SIGMAR1
sigma non-opioid intracellular receptor 1
chr17_+_38498594 0.16 ENST00000394081.3
RARA
retinoic acid receptor, alpha
chr10_+_94608245 0.16 ENST00000443748.2
ENST00000260762.6
EXOC6
exocyst complex component 6
chr17_-_79166176 0.16 ENST00000571292.1
AZI1
5-azacytidine induced 1
chr3_-_16554403 0.16 ENST00000449415.1
ENST00000441460.1
RFTN1
raftlin, lipid raft linker 1
chr19_+_14640372 0.16 ENST00000215567.5
ENST00000598298.1
ENST00000596073.1
ENST00000600083.1
ENST00000436007.2
TECR
trans-2,3-enoyl-CoA reductase
chr19_+_1905365 0.16 ENST00000329478.2
ENST00000602400.1
ENST00000409472.1
ADAT3
SCAMP4
adenosine deaminase, tRNA-specific 3
secretory carrier membrane protein 4
chr19_+_10362577 0.16 ENST00000592514.1
ENST00000307422.5
ENST00000253099.6
ENST00000590150.1
ENST00000590669.1
MRPL4
mitochondrial ribosomal protein L4
chrX_-_102319092 0.16 ENST00000372728.3
BEX1
brain expressed, X-linked 1
chr7_-_92107229 0.15 ENST00000603053.1
ERVW-1
endogenous retrovirus group W, member 1
chr3_+_151531859 0.15 ENST00000488869.1
AADAC
arylacetamide deacetylase
chr1_-_24127256 0.15 ENST00000418277.1
GALE
UDP-galactose-4-epimerase
chr17_-_42200996 0.15 ENST00000587135.1
ENST00000225983.6
ENST00000393622.2
ENST00000588703.1
HDAC5
histone deacetylase 5
chr3_-_193096600 0.15 ENST00000446087.1
ENST00000342358.4
ATP13A5
ATPase type 13A5
chr22_+_21400229 0.15 ENST00000342608.4
ENST00000543388.1
ENST00000442047.1
AC002472.13
Leucine-rich repeat-containing protein LOC400891
chr20_-_30310656 0.15 ENST00000376055.4
BCL2L1
BCL2-like 1
chr2_-_27718052 0.15 ENST00000264703.3
FNDC4
fibronectin type III domain containing 4
chr1_-_186649543 0.15 ENST00000367468.5
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
chr6_+_15249128 0.15 ENST00000397311.3
JARID2
jumonji, AT rich interactive domain 2
chr8_-_104427313 0.15 ENST00000297578.4
SLC25A32
solute carrier family 25 (mitochondrial folate carrier), member 32
chr19_-_41859814 0.15 ENST00000221930.5
TGFB1
transforming growth factor, beta 1
chr19_-_12595586 0.15 ENST00000397732.3
ZNF709
zinc finger protein 709
chr2_-_24346218 0.14 ENST00000436622.1
ENST00000313213.4
PFN4
profilin family, member 4
chr17_-_27224621 0.14 ENST00000394906.2
ENST00000585169.1
ENST00000394908.4
FLOT2
flotillin 2
chr10_+_134000404 0.14 ENST00000338492.4
ENST00000368629.1
DPYSL4
dihydropyrimidinase-like 4
chr11_+_826136 0.14 ENST00000528315.1
ENST00000533803.1
EFCAB4A
EF-hand calcium binding domain 4A
chr17_-_4871085 0.14 ENST00000575142.1
ENST00000206020.3
SPAG7
sperm associated antigen 7
chr22_-_30685596 0.14 ENST00000404953.3
ENST00000407689.3
GATSL3
GATS protein-like 3
chr10_-_14880566 0.14 ENST00000378442.1
CDNF
cerebral dopamine neurotrophic factor
chr17_+_6658878 0.13 ENST00000574394.1
XAF1
XIAP associated factor 1
chr11_+_65292884 0.13 ENST00000527009.1
SCYL1
SCY1-like 1 (S. cerevisiae)
chr19_+_13875316 0.13 ENST00000319545.8
ENST00000593245.1
ENST00000040663.6
MRI1
methylthioribose-1-phosphate isomerase 1
chr5_-_141060389 0.13 ENST00000504448.1
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr14_-_21566731 0.13 ENST00000360947.3
ZNF219
zinc finger protein 219
chr19_+_56116771 0.13 ENST00000568956.1
ZNF865
zinc finger protein 865
chr19_+_17186577 0.13 ENST00000595618.1
ENST00000594824.1
MYO9B
myosin IXB
chr19_-_3772209 0.12 ENST00000555978.1
ENST00000555633.1
RAX2
retina and anterior neural fold homeobox 2
chr17_-_5015129 0.12 ENST00000575898.1
ENST00000416429.2
ZNF232
zinc finger protein 232
chr20_+_48807351 0.12 ENST00000303004.3
CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr12_+_57998400 0.12 ENST00000548804.1
ENST00000550596.1
ENST00000551835.1
ENST00000549583.1
DTX3
deltex homolog 3 (Drosophila)
chr6_-_32908792 0.12 ENST00000418107.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr19_+_45458503 0.12 ENST00000337392.5
ENST00000591304.1
CLPTM1
cleft lip and palate associated transmembrane protein 1
chrX_+_54834159 0.12 ENST00000375053.2
ENST00000347546.4
ENST00000375062.4
MAGED2
melanoma antigen family D, 2
chr19_-_17007026 0.12 ENST00000598792.1
CPAMD8
C3 and PZP-like, alpha-2-macroglobulin domain containing 8
chr8_-_11325047 0.12 ENST00000531804.1
FAM167A
family with sequence similarity 167, member A
chr4_-_111120132 0.12 ENST00000506625.1
ELOVL6
ELOVL fatty acid elongase 6
chrX_+_118108601 0.12 ENST00000371628.3
LONRF3
LON peptidase N-terminal domain and ring finger 3
chr19_+_17858547 0.12 ENST00000600676.1
ENST00000600209.1
ENST00000596309.1
ENST00000598539.1
ENST00000597474.1
ENST00000593385.1
ENST00000598067.1
ENST00000593833.1
FCHO1
FCH domain only 1
chr9_+_139847347 0.12 ENST00000371632.3
LCN12
lipocalin 12
chr17_+_80416050 0.11 ENST00000579198.1
ENST00000390006.4
ENST00000580296.1
NARF
nuclear prelamin A recognition factor

Network of associatons between targets according to the STRING database.

First level regulatory network of GLIS2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0045082 positive regulation of interleukin-10 biosynthetic process(GO:0045082)
0.3 1.1 GO:0010900 negative regulation of phosphatidylcholine catabolic process(GO:0010900)
0.3 0.8 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.2 0.7 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541) positive regulation of fibrinolysis(GO:0051919)
0.2 0.8 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
0.2 0.7 GO:0061760 antifungal innate immune response(GO:0061760)
0.2 0.5 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.1 0.6 GO:0038161 prolactin signaling pathway(GO:0038161)
0.1 1.2 GO:0051549 positive regulation of keratinocyte migration(GO:0051549)
0.1 0.5 GO:1990736 positive regulation of regulation of vascular smooth muscle cell membrane depolarization(GO:1904199) regulation of vascular smooth muscle cell membrane depolarization(GO:1990736)
0.1 0.3 GO:2001190 positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.1 0.5 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.1 0.3 GO:0002894 positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894)
0.1 0.3 GO:0051795 positive regulation of catagen(GO:0051795)
0.1 0.3 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.1 0.2 GO:0072720 cellular response to mycotoxin(GO:0036146) response to dithiothreitol(GO:0072720)
0.1 0.3 GO:1990936 metanephric glomerular mesangial cell development(GO:0072255) reversible differentiation(GO:0090677) cell dedifferentiation involved in phenotypic switching(GO:0090678) positive regulation of phenotypic switching(GO:1900241) regulation of vascular smooth muscle cell dedifferentiation(GO:1905174) positive regulation of vascular smooth muscle cell dedifferentiation(GO:1905176) vascular smooth muscle cell dedifferentiation(GO:1990936)
0.1 0.2 GO:0043181 vacuolar sequestering(GO:0043181)
0.1 0.3 GO:0006562 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
0.1 0.2 GO:0060490 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.1 0.5 GO:0060154 cellular process regulating host cell cycle in response to virus(GO:0060154)
0.1 0.4 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.1 0.3 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.0 0.2 GO:0035350 FAD transport(GO:0015883) FAD transmembrane transport(GO:0035350)
0.0 0.1 GO:2001280 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0 0.1 GO:0052510 induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553) modulation by virus of host immune response(GO:0075528)
0.0 0.2 GO:0021849 neuroblast division in subventricular zone(GO:0021849)
0.0 0.6 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.1 GO:0032489 regulation of Cdc42 protein signal transduction(GO:0032489)
0.0 0.3 GO:1902045 negative regulation of Fas signaling pathway(GO:1902045)
0.0 1.0 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.2 GO:0019046 release from viral latency(GO:0019046)
0.0 1.1 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.2 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.0 0.2 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
0.0 0.2 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.0 0.5 GO:0030497 fatty acid elongation(GO:0030497)
0.0 0.4 GO:0009912 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.0 0.1 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
0.0 0.1 GO:0098582 innate vocalization behavior(GO:0098582)
0.0 0.1 GO:0007506 gonadal mesoderm development(GO:0007506)
0.0 0.4 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.0 0.1 GO:0070845 misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846)
0.0 0.1 GO:0042270 protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.0 1.9 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.1 GO:1904298 positive regulation of neutrophil degranulation(GO:0043315) cellular response to gravity(GO:0071258) positive regulation of neutrophil activation(GO:1902565) regulation of transcytosis(GO:1904298) positive regulation of transcytosis(GO:1904300) regulation of maternal process involved in parturition(GO:1904301) positive regulation of maternal process involved in parturition(GO:1904303) response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904316) cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904317)
0.0 0.3 GO:0097113 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.0 0.2 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0 0.1 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.0 0.3 GO:0002159 desmosome assembly(GO:0002159)
0.0 0.2 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.0 0.1 GO:0043012 regulation of fusion of sperm to egg plasma membrane(GO:0043012)
0.0 0.1 GO:0021993 initiation of neural tube closure(GO:0021993)
0.0 0.1 GO:1903903 regulation of establishment of T cell polarity(GO:1903903)
0.0 0.1 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.0 0.1 GO:0071344 diphosphate metabolic process(GO:0071344)
0.0 0.1 GO:0042247 morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
0.0 0.1 GO:0071922 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 0.2 GO:0035507 regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.0 0.2 GO:0070294 renal sodium ion absorption(GO:0070294)
0.0 0.2 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 0.2 GO:0032237 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.1 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.0 0.8 GO:0032094 response to food(GO:0032094)
0.0 0.3 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 0.6 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.0 0.3 GO:0090344 negative regulation of cell aging(GO:0090344)
0.0 0.3 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.1 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 0.1 GO:0060032 notochord regression(GO:0060032)
0.0 0.3 GO:0032785 negative regulation of DNA-templated transcription, elongation(GO:0032785)
0.0 0.1 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.1 GO:0060971 intraciliary anterograde transport(GO:0035720) ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830) embryonic heart tube left/right pattern formation(GO:0060971)
0.0 0.1 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0 0.1 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.0 0.1 GO:0034447 very-low-density lipoprotein particle clearance(GO:0034447)
0.0 0.1 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.1 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.0 0.1 GO:0044565 dendritic cell proliferation(GO:0044565)
0.0 0.3 GO:0050832 defense response to fungus(GO:0050832)
0.0 0.9 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.2 GO:0060263 regulation of respiratory burst(GO:0060263)
0.0 0.1 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.0 0.5 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.0 0.0 GO:0072156 distal tubule morphogenesis(GO:0072156) metanephric distal tubule morphogenesis(GO:0072287)
0.0 0.2 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.1 GO:0002457 T cell antigen processing and presentation(GO:0002457)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.1 0.5 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.1 0.5 GO:0005579 membrane attack complex(GO:0005579)
0.1 1.3 GO:0042627 chylomicron(GO:0042627)
0.1 0.2 GO:1990666 PCSK9-LDLR complex(GO:1990666)
0.1 0.3 GO:0031523 Myb complex(GO:0031523)
0.1 0.7 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 0.3 GO:0032044 DSIF complex(GO:0032044)
0.0 0.2 GO:0031084 BLOC-2 complex(GO:0031084)
0.0 0.3 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.2 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.0 0.1 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.2 GO:0089701 U2AF(GO:0089701)
0.0 0.2 GO:0036338 viral envelope(GO:0019031) viral membrane(GO:0036338)
0.0 0.4 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.4 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.3 GO:0098839 postsynaptic density membrane(GO:0098839)
0.0 0.4 GO:0097433 dense body(GO:0097433)
0.0 0.2 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 1.3 GO:0045095 keratin filament(GO:0045095)
0.0 1.9 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.1 GO:0020018 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.0 0.2 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.1 GO:0055087 Ski complex(GO:0055087)
0.0 0.1 GO:0042643 actomyosin, actin portion(GO:0042643)
0.0 0.5 GO:0034706 sodium channel complex(GO:0034706)
0.0 0.2 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.1 GO:0005840 ribosome(GO:0005840)
0.0 0.2 GO:0071439 clathrin complex(GO:0071439)
0.0 1.2 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.3 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.1 GO:0044305 calyx of Held(GO:0044305)
0.0 0.1 GO:0005638 lamin filament(GO:0005638)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.2 0.5 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.2 1.2 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.1 1.1 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.1 0.3 GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity(GO:0003842)
0.1 0.3 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 0.2 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.1 0.3 GO:0004966 galanin receptor activity(GO:0004966)
0.1 0.2 GO:0003978 UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978)
0.0 0.2 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.0 1.0 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.3 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 0.5 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.3 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0 0.5 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.3 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.0 0.9 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 1.2 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.2 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.0 0.1 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666) arachidonate 15-lipoxygenase activity(GO:0050473)
0.0 0.5 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.5 GO:0019841 retinol binding(GO:0019841)
0.0 0.1 GO:0045131 pre-mRNA branch point binding(GO:0045131)
0.0 0.2 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 0.3 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.9 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.8 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.1 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
0.0 0.3 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 0.2 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.2 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 0.1 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.0 0.6 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.1 GO:0004992 platelet activating factor receptor activity(GO:0004992)
0.0 0.2 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.0 2.0 GO:0003823 antigen binding(GO:0003823)
0.0 0.1 GO:0050119 N-acetylglucosamine deacetylase activity(GO:0050119)
0.0 0.7 GO:0005123 death receptor binding(GO:0005123)
0.0 0.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.4 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.3 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.4 GO:0005112 Notch binding(GO:0005112)
0.0 0.2 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 0.1 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.1 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.3 GO:0005024 transforming growth factor beta-activated receptor activity(GO:0005024)
0.0 0.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.0 GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119)
0.0 0.3 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.2 GO:0043996 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.9 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.0 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 1.2 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 0.5 PID S1P S1P1 PATHWAY S1P1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.1 1.0 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.7 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 1.1 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.6 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.4 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.5 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.8 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 0.2 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.4 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.4 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.5 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.4 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.5 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.4 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.3 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling