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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for GATA6

Z-value: 0.43

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Transcription factors associated with GATA6

Gene Symbol Gene ID Gene Info
GATA6
ENSG00000141448.4 GATA binding protein 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GATA6hg19_v2_chr18_+_19749386_197494040.207.0e-01Click!

Activity profile of GATA6 motif

Sorted Z-values of GATA6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_131409476 0.53 ENST00000296871.2
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr6_+_12290586 0.44 ENST00000379375.5
EDN1
endothelin 1
chr5_-_141703713 0.34 ENST00000511815.1
SPRY4
sprouty homolog 4 (Drosophila)
chr2_+_102928009 0.20 ENST00000404917.2
ENST00000447231.1
IL1RL1
interleukin 1 receptor-like 1
chr1_-_226187013 0.17 ENST00000272091.7
SDE2
SDE2 telomere maintenance homolog (S. pombe)
chr14_+_75988851 0.17 ENST00000555504.1
BATF
basic leucine zipper transcription factor, ATF-like
chr4_-_48683188 0.15 ENST00000505759.1
FRYL
FRY-like
chr2_+_102927962 0.13 ENST00000233954.1
ENST00000393393.3
ENST00000410040.1
IL1RL1
IL18R1
interleukin 1 receptor-like 1
interleukin 18 receptor 1
chr10_+_118349920 0.13 ENST00000531984.1
PNLIPRP1
pancreatic lipase-related protein 1
chr4_-_103266219 0.12 ENST00000394833.2
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr1_-_205912577 0.12 ENST00000367135.3
ENST00000367134.2
SLC26A9
solute carrier family 26 (anion exchanger), member 9
chr7_+_155090271 0.11 ENST00000476756.1
INSIG1
insulin induced gene 1
chr9_+_33795533 0.11 ENST00000379405.3
PRSS3
protease, serine, 3
chr5_-_135290705 0.11 ENST00000274507.1
LECT2
leukocyte cell-derived chemotaxin 2
chr2_-_202298268 0.10 ENST00000440597.1
TRAK2
trafficking protein, kinesin binding 2
chr11_-_26743546 0.10 ENST00000280467.6
ENST00000396005.3
SLC5A12
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
chr14_-_38036271 0.09 ENST00000556024.1
RP11-356O9.2
RP11-356O9.2
chr6_-_86099898 0.09 ENST00000455071.1
RP11-30P6.6
RP11-30P6.6
chr17_+_38673270 0.09 ENST00000578280.1
RP5-1028K7.2
RP5-1028K7.2
chr4_-_103266355 0.09 ENST00000424970.2
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr11_-_10920714 0.09 ENST00000533941.1
CTD-2003C8.2
CTD-2003C8.2
chr3_+_88188254 0.09 ENST00000309495.5
ZNF654
zinc finger protein 654
chrX_+_107288280 0.09 ENST00000458383.1
VSIG1
V-set and immunoglobulin domain containing 1
chr7_-_107880508 0.08 ENST00000425651.2
NRCAM
neuronal cell adhesion molecule
chr13_-_46716969 0.08 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr5_+_135496675 0.08 ENST00000507637.1
SMAD5
SMAD family member 5
chr7_-_100239132 0.08 ENST00000223051.3
ENST00000431692.1
TFR2
transferrin receptor 2
chr1_+_206317450 0.08 ENST00000358184.2
ENST00000361052.3
ENST00000360218.2
CTSE
cathepsin E
chr18_+_19749386 0.08 ENST00000269216.3
GATA6
GATA binding protein 6
chr1_+_25598872 0.07 ENST00000328664.4
RHD
Rh blood group, D antigen
chr1_-_27240455 0.07 ENST00000254227.3
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr12_+_4430371 0.07 ENST00000179259.4
C12orf5
chromosome 12 open reading frame 5
chr2_-_214015111 0.06 ENST00000433134.1
IKZF2
IKAROS family zinc finger 2 (Helios)
chr12_+_122880045 0.06 ENST00000539034.1
ENST00000535976.1
RP11-450K4.1
RP11-450K4.1
chr4_+_100495864 0.06 ENST00000265517.5
ENST00000422897.2
MTTP
microsomal triglyceride transfer protein
chr10_+_118305435 0.06 ENST00000369221.2
PNLIP
pancreatic lipase
chr1_-_120354079 0.06 ENST00000354219.1
ENST00000369401.4
ENST00000256585.5
REG4
regenerating islet-derived family, member 4
chrX_+_107288239 0.06 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr1_-_94050668 0.06 ENST00000539242.1
BCAR3
breast cancer anti-estrogen resistance 3
chrX_+_107288197 0.06 ENST00000415430.3
VSIG1
V-set and immunoglobulin domain containing 1
chr14_-_38028689 0.05 ENST00000553425.1
RP11-356O9.2
RP11-356O9.2
chr1_-_24469602 0.05 ENST00000270800.1
IL22RA1
interleukin 22 receptor, alpha 1
chr5_-_135290651 0.05 ENST00000522943.1
ENST00000514447.2
LECT2
leukocyte cell-derived chemotaxin 2
chr14_-_21945057 0.05 ENST00000397762.1
RAB2B
RAB2B, member RAS oncogene family
chr19_-_51522955 0.05 ENST00000358789.3
KLK10
kallikrein-related peptidase 10
chr16_+_4475806 0.05 ENST00000262375.6
ENST00000355296.4
ENST00000431375.2
ENST00000574895.1
DNAJA3
DnaJ (Hsp40) homolog, subfamily A, member 3
chr1_+_66999799 0.04 ENST00000371035.3
ENST00000371036.3
ENST00000371037.4
SGIP1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr1_+_206317591 0.04 ENST00000432969.2
CTSE
cathepsin E
chr19_-_13213954 0.04 ENST00000590974.1
LYL1
lymphoblastic leukemia derived sequence 1
chr20_+_54967409 0.04 ENST00000415828.1
ENST00000217109.4
ENST00000428552.1
CSTF1
cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
chr20_-_30795511 0.04 ENST00000246229.4
PLAGL2
pleiomorphic adenoma gene-like 2
chr19_-_51523275 0.04 ENST00000309958.3
KLK10
kallikrein-related peptidase 10
chr9_+_125796806 0.04 ENST00000373642.1
GPR21
G protein-coupled receptor 21
chr19_-_11494975 0.03 ENST00000222139.6
ENST00000592375.2
EPOR
erythropoietin receptor
chr8_+_21823726 0.03 ENST00000433566.4
XPO7
exportin 7
chr10_-_99531709 0.03 ENST00000266066.3
SFRP5
secreted frizzled-related protein 5
chr15_-_64126084 0.03 ENST00000560316.1
ENST00000443617.2
ENST00000560462.1
ENST00000558532.1
ENST00000561400.1
HERC1
HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
chr4_+_15376165 0.03 ENST00000382383.3
ENST00000429690.1
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr17_-_62084241 0.03 ENST00000449662.2
ICAM2
intercellular adhesion molecule 2
chr17_+_56833184 0.03 ENST00000308249.2
PPM1E
protein phosphatase, Mg2+/Mn2+ dependent, 1E
chr17_+_19314505 0.03 ENST00000461366.1
RNF112
ring finger protein 112
chr22_+_35462129 0.02 ENST00000404699.2
ENST00000308700.6
ISX
intestine-specific homeobox
chr3_+_69812877 0.02 ENST00000457080.1
ENST00000328528.6
MITF
microphthalmia-associated transcription factor
chr2_-_44065889 0.02 ENST00000543989.1
ENST00000405322.1
ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr6_-_46048116 0.02 ENST00000185206.6
CLIC5
chloride intracellular channel 5
chr12_+_109785708 0.02 ENST00000310903.5
MYO1H
myosin IH
chr13_+_24144796 0.02 ENST00000403372.2
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr20_+_51588873 0.02 ENST00000371497.5
TSHZ2
teashirt zinc finger homeobox 2
chr19_-_55549624 0.02 ENST00000417454.1
ENST00000310373.3
ENST00000333884.2
GP6
glycoprotein VI (platelet)
chr18_+_43304137 0.02 ENST00000502059.2
ENST00000586951.1
ENST00000589322.2
ENST00000415427.3
ENST00000535474.1
ENST00000402943.2
SLC14A1
solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
chr7_+_150690857 0.02 ENST00000484524.1
ENST00000467517.1
NOS3
nitric oxide synthase 3 (endothelial cell)
chr13_+_24144509 0.02 ENST00000248484.4
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr20_+_54967663 0.02 ENST00000452950.1
CSTF1
cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
chr10_+_71075552 0.02 ENST00000298649.3
HK1
hexokinase 1
chr20_-_60294804 0.02 ENST00000317652.1
RP11-429E11.3
Uncharacterized protein
chr12_+_72332618 0.02 ENST00000333850.3
TPH2
tryptophan hydroxylase 2
chr5_-_33984741 0.01 ENST00000382102.3
ENST00000509381.1
ENST00000342059.3
ENST00000345083.5
SLC45A2
solute carrier family 45, member 2
chr17_+_19314432 0.01 ENST00000575165.2
RNF112
ring finger protein 112
chr2_+_138722028 0.01 ENST00000280096.5
HNMT
histamine N-methyltransferase
chr15_+_59279851 0.01 ENST00000348370.4
ENST00000434298.1
ENST00000559160.1
RNF111
ring finger protein 111
chr3_+_137717571 0.01 ENST00000343735.4
CLDN18
claudin 18
chr17_-_38938786 0.01 ENST00000301656.3
KRT27
keratin 27
chr2_+_220495800 0.01 ENST00000413743.1
SLC4A3
solute carrier family 4 (anion exchanger), member 3
chr7_+_128379346 0.01 ENST00000535011.2
ENST00000542996.2
ENST00000535623.1
ENST00000538546.1
ENST00000249364.4
ENST00000449187.2
CALU
calumenin
chr10_+_71075516 0.01 ENST00000436817.1
HK1
hexokinase 1
chr16_+_67022633 0.01 ENST00000398354.1
ENST00000326686.5
CES4A
carboxylesterase 4A
chr12_+_111843749 0.01 ENST00000341259.2
SH2B3
SH2B adaptor protein 3
chr22_-_29784519 0.01 ENST00000357586.2
ENST00000356015.2
ENST00000432560.2
ENST00000317368.7
AP1B1
adaptor-related protein complex 1, beta 1 subunit
chr2_+_173792893 0.01 ENST00000535187.1
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr20_+_43029911 0.01 ENST00000443598.2
ENST00000316099.4
ENST00000415691.2
HNF4A
hepatocyte nuclear factor 4, alpha
chr15_-_38852251 0.01 ENST00000558432.1
RASGRP1
RAS guanyl releasing protein 1 (calcium and DAG-regulated)
chr14_+_53173910 0.00 ENST00000606149.1
ENST00000555339.1
ENST00000556813.1
PSMC6
proteasome (prosome, macropain) 26S subunit, ATPase, 6
chr5_-_33984786 0.00 ENST00000296589.4
SLC45A2
solute carrier family 45, member 2
chr16_+_333152 0.00 ENST00000219406.6
ENST00000404312.1
ENST00000456379.1
PDIA2
protein disulfide isomerase family A, member 2
chr14_+_53173890 0.00 ENST00000445930.2
PSMC6
proteasome (prosome, macropain) 26S subunit, ATPase, 6
chr11_-_59612969 0.00 ENST00000541311.1
ENST00000257248.2
GIF
gastric intrinsic factor (vitamin B synthesis)
chr8_-_93107443 0.00 ENST00000360348.2
ENST00000520428.1
ENST00000518992.1
ENST00000520556.1
ENST00000518317.1
ENST00000521319.1
ENST00000521375.1
ENST00000518449.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr2_+_109237717 0.00 ENST00000409441.1
LIMS1
LIM and senescent cell antigen-like domains 1
chr12_+_53818855 0.00 ENST00000550839.1
AMHR2
anti-Mullerian hormone receptor, type II
chr4_-_186696636 0.00 ENST00000444771.1
SORBS2
sorbin and SH3 domain containing 2
chr17_+_72920370 0.00 ENST00000331427.4
OTOP2
otopetrin 2
chr5_+_131892815 0.00 ENST00000453394.1
RAD50
RAD50 homolog (S. cerevisiae)

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.1 0.4 GO:0060585 nitric oxide transport(GO:0030185) negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0 0.3 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.0 0.1 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.0 0.1 GO:0098972 dendritic transport of mitochondrion(GO:0098939) anterograde dendritic transport of mitochondrion(GO:0098972)
0.0 0.1 GO:0051891 positive regulation of cardioblast differentiation(GO:0051891)
0.0 0.2 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0 0.1 GO:0001880 Mullerian duct regression(GO:0001880)
0.0 0.1 GO:0070627 ferrous iron import(GO:0070627) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.0 0.0 GO:0038162 erythropoietin-mediated signaling pathway(GO:0038162)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 0.1 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0031705 bombesin receptor binding(GO:0031705)
0.1 0.3 GO:0002113 interleukin-33 binding(GO:0002113)
0.0 0.1 GO:0004998 transferrin receptor activity(GO:0004998)