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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for GATA3
Z-value: 2.55
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Transcription factors associated with GATA3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GATA3 | hg19_v2_chr10_+_8096769_8096787 | -0.51 | 3.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of GATA3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.0 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.1 | 6.2 | GO:0034340 | response to type I interferon(GO:0034340) |
| 0.3 | 3.6 | GO:0030223 | neutrophil differentiation(GO:0030223) |
| 0.0 | 3.4 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 3.3 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.3 | 3.2 | GO:1904180 | negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180) |
| 0.8 | 2.5 | GO:0045362 | regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) |
| 0.0 | 2.4 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 0.4 | 2.2 | GO:0085032 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 0.7 | 2.1 | GO:0032747 | positive regulation of interleukin-23 production(GO:0032747) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.9 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 4.2 | GO:0034774 | secretory granule lumen(GO:0034774) |
| 0.0 | 3.7 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 3.0 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 2.8 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 2.4 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 2.0 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 0.1 | 1.9 | GO:0031462 | Cul2-RING ubiquitin ligase complex(GO:0031462) |
| 0.1 | 1.9 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 1.9 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 3.6 | GO:0070851 | growth factor receptor binding(GO:0070851) |
| 0.1 | 3.3 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 3.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 3.1 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.9 | 2.8 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
| 0.0 | 2.7 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.0 | 2.5 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.1 | 2.4 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.1 | 2.4 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 4.7 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 3.3 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 2.8 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 2.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 2.5 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.1 | 2.4 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 2.4 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.1 | 2.0 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.0 | 1.9 | ST GA12 PATHWAY | G alpha 12 Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.1 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 5.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 3.7 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 2.6 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 2.6 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 0.0 | 2.6 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 2.5 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 2.5 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.1 | 2.1 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.0 | 2.1 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |