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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for FOXO3_FOXD2
Z-value: 0.68
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Transcription factors associated with FOXO3_FOXD2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXO3 | hg19_v2_chr6_+_108882069_108882087 | 0.42 | 4.1e-01 | Click! |
| FOXD2 | hg19_v2_chr1_+_47901689_47901689 | 0.15 | 7.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_116654376 Show fit | 0.81 |
ENST00000369500.3
|
mab-21-like 3 (C. elegans) |
|
| chr4_+_165675197 Show fit | 0.65 |
ENST00000515485.1
|
RP11-294O2.2 |
|
| chr3_+_178865887 Show fit | 0.55 |
ENST00000477735.1
|
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
|
| chr6_-_113754604 Show fit | 0.55 |
ENST00000421737.1
|
RP1-124C6.1 |
|
| chr1_+_84630574 Show fit | 0.51 |
ENST00000413538.1
ENST00000417530.1 |
protein kinase, cAMP-dependent, catalytic, beta |
|
| chr6_+_21666633 Show fit | 0.50 |
ENST00000606851.1
|
cancer susceptibility candidate 15 (non-protein coding) |
|
| chr3_-_185826718 Show fit | 0.43 |
ENST00000413301.1
ENST00000421809.1 |
ets variant 5 |
|
| chr12_+_96588279 Show fit | 0.39 |
ENST00000552142.1
|
ELK3, ETS-domain protein (SRF accessory protein 2) |
|
| chr1_+_120839412 Show fit | 0.38 |
ENST00000355228.4
|
family with sequence similarity 72, member B |
|
| chr14_+_38065052 Show fit | 0.37 |
ENST00000556845.1
|
tetratricopeptide repeat domain 6 |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXO3_FOXD2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.4 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.2 | 0.7 | GO:0044029 | DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029) |
| 0.0 | 0.7 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 0.1 | 0.6 | GO:0048133 | germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728) |
| 0.0 | 0.6 | GO:0045876 | positive regulation of sister chromatid cohesion(GO:0045876) |
| 0.0 | 0.4 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.0 | 0.4 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.0 | 0.4 | GO:1904355 | positive regulation of telomere capping(GO:1904355) |
| 0.0 | 0.4 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.0 | 0.3 | GO:0097428 | protein maturation by iron-sulfur cluster transfer(GO:0097428) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.4 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.1 | 0.7 | GO:0097149 | centralspindlin complex(GO:0097149) |
| 0.1 | 0.7 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
| 0.1 | 0.6 | GO:0000798 | nuclear cohesin complex(GO:0000798) |
| 0.0 | 0.5 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.1 | 0.4 | GO:0042721 | mitochondrial inner membrane protein insertion complex(GO:0042721) |
| 0.0 | 0.3 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.0 | 0.3 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
| 0.0 | 0.3 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.0 | 0.3 | GO:0033391 | chromatoid body(GO:0033391) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.4 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.1 | 0.7 | GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005) |
| 0.0 | 0.7 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 0.5 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
| 0.0 | 0.5 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.0 | 0.4 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.0 | 0.4 | GO:0005537 | mannose binding(GO:0005537) |
| 0.0 | 0.4 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.1 | 0.3 | GO:0051499 | D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500) |
| 0.1 | 0.3 | GO:0050115 | myosin-light-chain-phosphatase activity(GO:0050115) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 0.6 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 0.4 | ST G ALPHA S PATHWAY | G alpha s Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 0.9 | REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | Genes involved in Signaling by constitutively active EGFR |
| 0.0 | 0.6 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.0 | 0.2 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.0 | 0.0 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |