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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for FOXM1_TBL1XR1
Z-value: 2.67
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Transcription factors associated with FOXM1_TBL1XR1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBL1XR1 | hg19_v2_chr3_-_176914998_176915021 | 0.35 | 5.0e-01 | Click! |
| FOXM1 | hg19_v2_chr12_-_2986107_2986258 | -0.33 | 5.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_56813305 Show fit | 2.51 |
ENST00000593151.1
|
Uncharacterized protein |
|
| chr1_-_179457805 Show fit | 1.89 |
ENST00000600581.1
|
Uncharacterized protein |
|
| chr4_-_85771168 Show fit | 1.78 |
ENST00000514071.1
|
WD repeat and FYVE domain containing 3 |
|
| chr10_-_5652705 Show fit | 1.68 |
ENST00000425246.1
|
RP11-336A10.5 |
|
| chr7_-_17598506 Show fit | 1.46 |
ENST00000451792.1
|
AC017060.1 |
|
| chr1_-_205391178 Show fit | 1.44 |
ENST00000367153.4
ENST00000367151.2 ENST00000391936.2 ENST00000367149.3 |
LEM domain containing 1 |
|
| chr4_-_137842536 Show fit | 1.43 |
ENST00000512039.1
|
RP11-138I17.1 |
|
| chr9_-_112970436 Show fit | 1.28 |
ENST00000400613.4
|
chromosome 9 open reading frame 152 |
|
| chr12_-_8815299 Show fit | 1.21 |
ENST00000535336.1
|
microfibrillar associated protein 5 |
|
| chr6_-_53530474 Show fit | 1.16 |
ENST00000370905.3
|
kelch-like family member 31 |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXM1_TBL1XR1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.5 | GO:0060216 | definitive hemopoiesis(GO:0060216) |
| 0.5 | 2.5 | GO:0070124 | mitochondrial translational initiation(GO:0070124) |
| 0.1 | 2.3 | GO:0022011 | myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292) |
| 0.0 | 2.3 | GO:0010389 | regulation of G2/M transition of mitotic cell cycle(GO:0010389) |
| 0.1 | 2.2 | GO:0046007 | negative regulation of activated T cell proliferation(GO:0046007) |
| 0.1 | 2.2 | GO:0071157 | negative regulation of cell cycle arrest(GO:0071157) |
| 0.2 | 2.1 | GO:0035973 | aggrephagy(GO:0035973) |
| 0.2 | 2.0 | GO:0009449 | gamma-aminobutyric acid biosynthetic process(GO:0009449) |
| 0.0 | 1.9 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 0.0 | 1.9 | GO:0000245 | spliceosomal complex assembly(GO:0000245) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 3.8 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 3.6 | GO:0000922 | spindle pole(GO:0000922) |
| 0.0 | 2.8 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 2.6 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 2.6 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 2.3 | GO:0097342 | ripoptosome(GO:0097342) |
| 0.0 | 2.2 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.2 | 1.9 | GO:0097169 | AIM2 inflammasome complex(GO:0097169) |
| 0.0 | 1.9 | GO:0031201 | SNARE complex(GO:0031201) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.2 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.0 | 4.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 2.9 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.1 | 2.8 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 0.0 | 2.7 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.0 | 2.6 | GO:0061650 | ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650) |
| 0.0 | 2.6 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.0 | 2.6 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 2.5 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.1 | 2.1 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 3.7 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 3.6 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 3.3 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 3.1 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 2.6 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.1 | 2.3 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.1 | 2.2 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 2.1 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 2.0 | PID E2F PATHWAY | E2F transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.5 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 0.1 | 2.7 | REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A | Genes involved in APC-Cdc20 mediated degradation of Nek2A |
| 0.1 | 2.7 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 2.6 | REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 | Genes involved in SCF(Skp2)-mediated degradation of p27/p21 |
| 0.1 | 2.5 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 2.4 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.1 | 2.3 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.0 | 2.2 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 2.1 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 0.0 | 1.9 | REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES | Genes involved in Recruitment of mitotic centrosome proteins and complexes |