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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for FOXL1
Z-value: 0.79
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Transcription factors associated with FOXL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXL1 | hg19_v2_chr16_+_86612112_86612123 | 0.81 | 4.9e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXL1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.2 | GO:0010430 | fatty acid omega-oxidation(GO:0010430) |
| 0.1 | 0.7 | GO:0071494 | cellular response to UV-C(GO:0071494) |
| 0.0 | 0.7 | GO:0006999 | nuclear pore organization(GO:0006999) |
| 0.1 | 0.6 | GO:0061370 | testosterone biosynthetic process(GO:0061370) |
| 0.1 | 0.6 | GO:0006021 | inositol biosynthetic process(GO:0006021) |
| 0.1 | 0.6 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.1 | 0.5 | GO:1900004 | regulation of serine-type endopeptidase activity(GO:1900003) negative regulation of serine-type endopeptidase activity(GO:1900004) regulation of serine-type peptidase activity(GO:1902571) negative regulation of serine-type peptidase activity(GO:1902572) |
| 0.0 | 0.5 | GO:0002084 | protein depalmitoylation(GO:0002084) |
| 0.0 | 0.5 | GO:0015889 | cobalamin transport(GO:0015889) |
| 0.0 | 0.5 | GO:0000042 | protein targeting to Golgi(GO:0000042) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.8 | GO:0097179 | protease inhibitor complex(GO:0097179) |
| 0.0 | 0.5 | GO:0005652 | nuclear lamina(GO:0005652) |
| 0.0 | 0.5 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.0 | 0.5 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 0.4 | GO:0031429 | box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) |
| 0.0 | 0.4 | GO:0034464 | BBSome(GO:0034464) |
| 0.0 | 0.3 | GO:0031673 | H zone(GO:0031673) |
| 0.0 | 0.3 | GO:0031211 | serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211) |
| 0.0 | 0.3 | GO:0005818 | astral microtubule(GO:0000235) aster(GO:0005818) |
| 0.0 | 0.3 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.2 | GO:0004031 | aldehyde oxidase activity(GO:0004031) |
| 0.1 | 0.6 | GO:0031403 | lithium ion binding(GO:0031403) |
| 0.1 | 0.6 | GO:0047045 | testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045) |
| 0.0 | 0.6 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.0 | 0.5 | GO:0031419 | cobalamin binding(GO:0031419) |
| 0.0 | 0.5 | GO:0098599 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.0 | 0.5 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.0 | 0.5 | GO:0005527 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.1 | 0.4 | GO:0008193 | tRNA guanylyltransferase activity(GO:0008193) |
| 0.1 | 0.4 | GO:0004510 | tryptophan 5-monooxygenase activity(GO:0004510) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.0 | 0.3 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 0.3 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.0 | 0.1 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.2 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.0 | 0.6 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 0.6 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.0 | 0.6 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.0 | 0.5 | REACTOME ANDROGEN BIOSYNTHESIS | Genes involved in Androgen biosynthesis |
| 0.0 | 0.5 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 0.4 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.0 | 0.4 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.0 | 0.4 | REACTOME AMINE COMPOUND SLC TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.0 | 0.3 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |