ISMARA results: FOSL1

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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for FOSL1

Z-value: 1.60

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Transcription factors associated with FOSL1

Gene Symbol	Gene ID	Gene Info
FOSL1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000175592.4	FOS like 1, AP-1 transcription factor subunit

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
FOSL1	hg19_v2_chr11_-_65667997_65668044	0.96	1.9e-03	Click!

Activity profile of FOSL1 motif

Sorted Z-values of FOSL1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_-_153013588 Show fit	3.91	ENST00000360379.3	SPRR2D Ensembl NCBI GeneCards UniProt NextProt Show fit	small proline-rich protein 2D
chr7_+_22766766 Show fit	3.54	ENST00000426291.1 ENST00000401651.1 ENST00000258743.5 ENST00000420258.2 ENST00000407492.1 ENST00000401630.3 ENST00000406575.1	IL6 Ensembl NCBI GeneCards UniProt NextProt Show fit	interleukin 6 (interferon, beta 2)
chr1_-_153066998 Show fit	2.78	ENST00000368750.3	SPRR2E Ensembl NCBI GeneCards UniProt NextProt Show fit	small proline-rich protein 2E
chr4_+_74606223 Show fit	2.69	ENST00000307407.3 ENST00000401931.1	IL8 Ensembl NCBI GeneCards UniProt NextProt Show fit	interleukin 8
chr20_+_44637526 Show fit	2.40	ENST00000372330.3	MMP9 Ensembl NCBI GeneCards UniProt NextProt Show fit	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr12_-_58159361 Show fit	1.97	ENST00000546567.1	CYP27B1 Ensembl NCBI GeneCards UniProt NextProt Show fit	cytochrome P450, family 27, subfamily B, polypeptide 1
chr1_-_153029980 Show fit	1.90	ENST00000392653.2	SPRR2A Ensembl NCBI GeneCards UniProt NextProt Show fit	small proline-rich protein 2A
chr6_+_138188551 Show fit	1.87	ENST00000237289.4 ENST00000433680.1	TNFAIP3 Ensembl NCBI GeneCards UniProt NextProt Show fit	tumor necrosis factor, alpha-induced protein 3
chr6_+_138188351 Show fit	1.78	ENST00000421450.1	TNFAIP3 Ensembl NCBI GeneCards UniProt NextProt Show fit	tumor necrosis factor, alpha-induced protein 3
chr5_+_147582348 Show fit	1.76	ENST00000514389.1	SPINK6 Ensembl NCBI GeneCards UniProt NextProt Show fit	serine peptidase inhibitor, Kazal type 6

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of FOSL1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	11.5	GO:0018149	peptide cross-linking(GO:0018149)
1.8	5.3	GO:0034148	regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) negative regulation of osteoclast proliferation(GO:0090291) negative regulation of CD40 signaling pathway(GO:2000349)
0.9	3.5	GO:0002384	hepatic immune response(GO:0002384) response to prolactin(GO:1990637)
0.3	2.4	GO:0051549	positive regulation of keratinocyte migration(GO:0051549)
0.4	2.1	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
0.7	2.0	GO:1901421	positive regulation of response to alcohol(GO:1901421)
0.4	1.8	GO:0060708	spongiotrophoblast differentiation(GO:0060708)
0.1	1.7	GO:1904714	regulation of chaperone-mediated autophagy(GO:1904714)
0.1	1.7	GO:0045109	intermediate filament organization(GO:0045109)
0.0	1.6	GO:0000186	activation of MAPKK activity(GO:0000186)

Showing 1 to 10 of 133 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	12.0	GO:0001533	cornified envelope(GO:0001533)
0.0	4.1	GO:1904724	tertiary granule lumen(GO:1904724)
0.7	3.5	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	3.2	GO:0005882	intermediate filament(GO:0005882)
0.0	2.1	GO:0015030	Cajal body(GO:0015030)
0.0	1.5	GO:0042734	presynaptic membrane(GO:0042734)
0.3	1.1	GO:0033257	Bcl3/NF-kappaB2 complex(GO:0033257)
0.0	1.1	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	1.0	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.2	0.8	GO:0005607	laminin-2 complex(GO:0005607)

Showing 1 to 10 of 56 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	8.9	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.3	5.8	GO:0061578	Lys63-specific deubiquitinase activity(GO:0061578)
0.5	4.3	GO:0030280	structural constituent of epidermis(GO:0030280)
0.4	3.5	GO:0005138	interleukin-6 receptor binding(GO:0005138)
0.0	3.1	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.1	2.7	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.0	2.6	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.7	2.1	GO:0008859	exoribonuclease II activity(GO:0008859)
0.0	2.0	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.6	1.8	GO:0005146	leukemia inhibitory factor receptor binding(GO:0005146)

Showing 1 to 10 of 90 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	15.8	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1	6.9	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.1	2.5	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	1.7	PID IL23 PATHWAY	IL23-mediated signaling events
0.0	1.6	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0	1.3	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.1	1.0	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	1.0	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	0.9	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.0	0.9	PID IL1 PATHWAY	IL1-mediated signaling events

Showing 1 to 10 of 22 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.7	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.2	4.8	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.2	3.6	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.1	3.3	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.1	2.6	REACTOME ACTIVATION OF GENES BY ATF4	Genes involved in Activation of Genes by ATF4
0.0	2.3	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.1	2.2	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.0	2.2	REACTOME ACTIVATION OF NF KAPPAB IN B CELLS	Genes involved in Activation of NF-kappaB in B Cells
0.0	2.1	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	2.1	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling

Showing 1 to 10 of 38 entries

Results for FOSL1

Z-value: 1.60

Motif logo

Transcription factors associated with FOSL1

Activity-expression correlation:

Activity profile of FOSL1 motif

Sorted Z-values of FOSL1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of FOSL1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: