ISMARA results: FLI1

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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for FLI1

Z-value: 1.09

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Transcription factors associated with FLI1

Gene Symbol	Gene ID	Gene Info
FLI1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000151702.12	Fli-1 proto-oncogene, ETS transcription factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
FLI1	hg19_v2_chr11_+_128634589_128634685	-0.30	5.6e-01	Click!

Activity profile of FLI1 motif

Sorted Z-values of FLI1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr17_+_4843594 Show fit	1.06	ENST00000570328.1	RNF167 Ensembl NCBI GeneCards UniProt NextProt Show fit	ring finger protein 167
chr22_+_27068766 Show fit	0.93	ENST00000435162.1 ENST00000437071.1 ENST00000440816.1 ENST00000421253.1	CTA-211A9.5 Ensembl NCBI GeneCards UniProt NextProt Show fit	CTA-211A9.5
chr17_-_8263538 Show fit	0.90	ENST00000535173.1	AC135178.1 Ensembl NCBI GeneCards UniProt NextProt Show fit	HCG1985372; Uncharacterized protein; cDNA FLJ37541 fis, clone BRCAN2026340
chr8_+_55466915 Show fit	0.73	ENST00000522711.2	RP11-53M11.3 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP11-53M11.3
chr15_+_23810903 Show fit	0.68	ENST00000564592.1	MKRN3 Ensembl NCBI GeneCards UniProt NextProt Show fit	makorin ring finger protein 3
chr1_-_152779104 Show fit	0.64	ENST00000606576.1 ENST00000368768.1	LCE1C Ensembl NCBI GeneCards UniProt NextProt Show fit	late cornified envelope 1C
chr11_-_62389577 Show fit	0.64	ENST00000534715.1	B3GAT3 Ensembl NCBI GeneCards UniProt NextProt Show fit	beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
chr9_+_2017063 Show fit	0.61	ENST00000457226.1	SMARCA2 Ensembl NCBI GeneCards UniProt NextProt Show fit	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr4_+_79567057 Show fit	0.60	ENST00000503259.1 ENST00000507802.1	RP11-792D21.2 Ensembl NCBI GeneCards UniProt NextProt Show fit	long intergenic non-protein coding RNA 1094
chr7_+_150020329 Show fit	0.54	ENST00000323078.7	LRRC61 Ensembl NCBI GeneCards UniProt NextProt Show fit	leucine rich repeat containing 61

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of FLI1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.1	GO:0018149	peptide cross-linking(GO:0018149)
0.0	1.0	GO:0002279	mast cell activation involved in immune response(GO:0002279) mast cell degranulation(GO:0043303)
0.1	0.9	GO:0032074	negative regulation of nuclease activity(GO:0032074)
0.0	0.9	GO:0050651	dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0	0.9	GO:0071800	podosome assembly(GO:0071800)
0.1	0.8	GO:0038203	TORC2 signaling(GO:0038203)
0.1	0.7	GO:0032218	riboflavin transport(GO:0032218)
0.1	0.6	GO:0036343	psychomotor behavior(GO:0036343)
0.1	0.6	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.6	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)

Showing 1 to 10 of 185 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.6	GO:0001533	cornified envelope(GO:0001533)
0.0	1.4	GO:0002102	podosome(GO:0002102)
0.0	1.0	GO:0042629	mast cell granule(GO:0042629)
0.0	0.8	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.8	GO:0005801	cis-Golgi network(GO:0005801)
0.0	0.6	GO:0031229	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1	0.4	GO:0072563	endothelial microparticle(GO:0072563)
0.0	0.4	GO:0055028	cortical microtubule(GO:0055028)
0.0	0.4	GO:0061689	tricellular tight junction(GO:0061689)
0.1	0.3	GO:0031933	telomeric heterochromatin(GO:0031933)

Showing 1 to 10 of 63 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.2	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.2	0.9	GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0	0.8	GO:0001784	phosphotyrosine binding(GO:0001784)
0.1	0.7	GO:0032217	riboflavin transporter activity(GO:0032217)
0.2	0.6	GO:0035248	alpha-1,4-N-acetylgalactosaminyltransferase activity(GO:0035248)
0.0	0.5	GO:0031821	G-protein coupled serotonin receptor binding(GO:0031821)
0.0	0.5	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.5	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	0.5	GO:0004950	G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.1	0.4	GO:0016603	glutaminyl-peptide cyclotransferase activity(GO:0016603)

Showing 1 to 10 of 117 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.1	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.7	PID S1P S1P4 PATHWAY	S1P4 pathway
0.0	0.2	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.1	0.1	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	0.1	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events

Showing 1 to 5 of 5 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
0.9	REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.8	REACTOME KINESINS	Genes involved in Kinesins
0.7	REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY	Genes involved in Adenylate cyclase inhibitory pathway
0.7	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.5	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.3	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.3	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.2	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.2	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.2	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway

Showing 1 to 10 of 16 entries

Results for FLI1

Z-value: 1.09

Motif logo

Transcription factors associated with FLI1

Activity-expression correlation:

Activity profile of FLI1 motif

Sorted Z-values of FLI1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of FLI1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: