Project
NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
Navigation
Downloads
Results for EZH2
Z-value: 1.39
Motif logo
Transcription factors associated with EZH2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EZH2 | hg19_v2_chr7_-_148581251_148581347 | -0.90 | 1.4e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_41740181 Show fit | 2.14 |
ENST00000442711.1
|
inhibin, beta A |
|
| chr6_-_31550192 Show fit | 1.45 |
ENST00000429299.2
ENST00000446745.2 |
lymphotoxin beta (TNF superfamily, member 3) |
|
| chr12_+_7167980 Show fit | 1.27 |
ENST00000360817.5
ENST00000402681.3 |
complement component 1, s subcomponent |
|
| chrY_+_15418467 Show fit | 1.26 |
ENST00000595988.1
|
Uncharacterized protein |
|
| chr6_+_31543334 Show fit | 1.23 |
ENST00000449264.2
|
tumor necrosis factor |
|
| chr2_+_228678550 Show fit | 1.03 |
ENST00000409189.3
ENST00000358813.4 |
chemokine (C-C motif) ligand 20 |
|
| chr5_+_92919043 Show fit | 0.99 |
ENST00000327111.3
|
nuclear receptor subfamily 2, group F, member 1 |
|
| chr2_+_45168875 Show fit | 0.98 |
ENST00000260653.3
|
SIX homeobox 3 |
|
| chr6_+_31895467 Show fit | 0.94 |
ENST00000556679.1
ENST00000456570.1 |
complement factor B Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B |
|
| chr6_+_31895480 Show fit | 0.85 |
ENST00000418949.2
ENST00000383177.3 ENST00000477310.1 |
complement component 2 Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B |
Network of associatons between targets according to the STRING database.
First level regulatory network of EZH2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.1 | GO:0060279 | regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279) |
| 0.1 | 1.9 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.2 | 1.4 | GO:0045084 | positive regulation of interleukin-12 biosynthetic process(GO:0045084) |
| 0.1 | 1.3 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.0 | 1.3 | GO:0003416 | endochondral bone growth(GO:0003416) |
| 0.4 | 1.2 | GO:0045994 | positive regulation of translational initiation by iron(GO:0045994) |
| 0.4 | 1.1 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 0.3 | 1.0 | GO:0045360 | regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) |
| 0.1 | 1.0 | GO:0021692 | cerebellar Purkinje cell layer morphogenesis(GO:0021692) |
| 0.1 | 0.8 | GO:0052565 | response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.0 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.7 | 2.2 | GO:0043511 | inhibin complex(GO:0043511) inhibin A complex(GO:0043512) |
| 0.0 | 1.6 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.1 | 1.4 | GO:0008091 | spectrin(GO:0008091) |
| 0.0 | 1.2 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 1.1 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 0.9 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 0.9 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 0.8 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 0.7 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.4 | 2.2 | GO:0034711 | inhibin binding(GO:0034711) |
| 0.1 | 2.0 | GO:0001848 | complement binding(GO:0001848) |
| 0.0 | 1.4 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.3 | 1.0 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
| 0.1 | 0.9 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 0.0 | 0.9 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.0 | 0.9 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.0 | 0.9 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.1 | 0.8 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 2.1 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.1 | 1.8 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 1.2 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 1.1 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.0 | 1.0 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.9 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 0.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.8 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 0.8 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.3 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.1 | 1.9 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.0 | 1.7 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.3 | 1.3 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.0 | 1.3 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.0 | 1.3 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 1.2 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.0 | 1.1 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 1.1 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 1.0 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |