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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for ETV6
Z-value: 1.20
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Transcription factors associated with ETV6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ETV6 | hg19_v2_chr12_+_11802753_11802834 | 0.29 | 5.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_153066998 Show fit | 1.71 |
ENST00000368750.3
|
small proline-rich protein 2E |
|
| chr15_-_80263506 Show fit | 1.14 |
ENST00000335661.6
|
BCL2-related protein A1 |
|
| chr1_-_153044083 Show fit | 1.10 |
ENST00000341611.2
|
small proline-rich protein 2B |
|
| chr17_+_77020325 Show fit | 1.06 |
ENST00000311661.4
|
C1q and tumor necrosis factor related protein 1 |
|
| chr17_+_77020224 Show fit | 1.02 |
ENST00000339142.2
|
C1q and tumor necrosis factor related protein 1 |
|
| chr5_-_150473127 Show fit | 0.81 |
ENST00000521001.1
|
TNFAIP3 interacting protein 1 |
|
| chr6_+_26156551 Show fit | 0.65 |
ENST00000304218.3
|
histone cluster 1, H1e |
|
| chr17_+_77020146 Show fit | 0.55 |
ENST00000579760.1
|
C1q and tumor necrosis factor related protein 1 |
|
| chr16_+_67226019 Show fit | 0.53 |
ENST00000379378.3
|
E2F transcription factor 4, p107/p130-binding |
|
| chr1_-_54518865 Show fit | 0.51 |
ENST00000371337.3
|
transmembrane protein 59 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ETV6
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.0 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.3 | 2.6 | GO:2000860 | positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860) |
| 0.2 | 1.9 | GO:1904379 | protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379) |
| 0.0 | 1.1 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 0.0 | 1.1 | GO:1901998 | toxin transport(GO:1901998) |
| 0.1 | 1.0 | GO:0010836 | negative regulation of protein ADP-ribosylation(GO:0010836) |
| 0.1 | 1.0 | GO:0045359 | positive regulation of interferon-beta biosynthetic process(GO:0045359) |
| 0.2 | 0.8 | GO:0071733 | transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579) |
| 0.2 | 0.8 | GO:0052250 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 0.0 | 0.8 | GO:0042255 | ribosome assembly(GO:0042255) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.8 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 2.6 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.2 | 1.9 | GO:0071818 | BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379) |
| 0.0 | 1.7 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 1.3 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.2 | 1.0 | GO:0010370 | perinucleolar chromocenter(GO:0010370) |
| 0.1 | 0.8 | GO:0097255 | R2TP complex(GO:0097255) |
| 0.1 | 0.7 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.0 | 0.7 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.0 | 0.6 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.6 | GO:0005518 | collagen binding(GO:0005518) |
| 0.1 | 1.9 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.2 | 1.7 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.0 | 1.5 | GO:0042162 | telomeric DNA binding(GO:0042162) |
| 0.1 | 1.1 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.1 | 1.1 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.1 | 1.0 | GO:0043141 | ATP-dependent 5'-3' DNA helicase activity(GO:0043141) |
| 0.0 | 0.8 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.1 | 0.7 | GO:0032564 | adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564) |
| 0.1 | 0.6 | GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.6 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.0 | 1.4 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 0.8 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.8 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 0.7 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 0.5 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 0.4 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 0.3 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.2 | PID BMP PATHWAY | BMP receptor signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 1.0 | REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.0 | 0.9 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.0 | 0.9 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.0 | 0.7 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.0 | 0.7 | REACTOME ELONGATION ARREST AND RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.0 | 0.7 | REACTOME TELOMERE MAINTENANCE | Genes involved in Telomere Maintenance |
| 0.0 | 0.6 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.0 | 0.5 | REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| 0.0 | 0.5 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |