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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for ETV4_ETS2
Z-value: 1.20
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Transcription factors associated with ETV4_ETS2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ETV4 | hg19_v2_chr17_-_41623691_41623715 | 0.68 | 1.4e-01 | Click! |
| ETS2 | hg19_v2_chr21_+_40181520_40181560 | -0.36 | 4.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_47324008 Show fit | 1.12 |
ENST00000425853.1
|
kinesin family member 9 |
|
| chr16_-_67260901 Show fit | 1.05 |
ENST00000341546.3
ENST00000409509.1 ENST00000433915.1 ENST00000454102.2 |
leucine rich repeat containing 29 Uncharacterized protein; cDNA FLJ57407, weakly similar to Mus musculus leucine rich repeat containing 29 (Lrrc29), mRNA |
|
| chr1_+_153330322 Show fit | 0.92 |
ENST00000368738.3
|
S100 calcium binding protein A9 |
|
| chr11_-_64885111 Show fit | 0.87 |
ENST00000528598.1
ENST00000310597.4 |
zinc finger, HIT-type containing 2 |
|
| chr3_-_47324242 Show fit | 0.87 |
ENST00000456548.1
ENST00000432493.1 ENST00000335044.2 ENST00000444589.2 |
kinesin family member 9 |
|
| chr2_+_74212073 Show fit | 0.87 |
ENST00000441217.1
|
AC073046.25 |
|
| chr15_-_80263506 Show fit | 0.87 |
ENST00000335661.6
|
BCL2-related protein A1 |
|
| chr6_+_31515337 Show fit | 0.84 |
ENST00000376148.4
ENST00000376145.4 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 |
|
| chr2_+_228678550 Show fit | 0.83 |
ENST00000409189.3
ENST00000358813.4 |
chemokine (C-C motif) ligand 20 |
|
| chr11_+_313503 Show fit | 0.77 |
ENST00000528780.1
ENST00000328221.5 |
interferon induced transmembrane protein 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ETV4_ETS2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.1 | GO:0071801 | regulation of podosome assembly(GO:0071801) |
| 0.1 | 1.4 | GO:1904327 | protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379) |
| 0.1 | 1.2 | GO:0030223 | neutrophil differentiation(GO:0030223) |
| 0.2 | 1.1 | GO:0036343 | psychomotor behavior(GO:0036343) |
| 0.2 | 1.1 | GO:0010989 | negative regulation of low-density lipoprotein particle clearance(GO:0010989) |
| 0.3 | 1.0 | GO:0035606 | peptidyl-cysteine S-trans-nitrosylation(GO:0035606) |
| 0.3 | 0.9 | GO:0045362 | regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) |
| 0.1 | 0.9 | GO:0044034 | negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034) |
| 0.0 | 0.9 | GO:0031665 | negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665) |
| 0.0 | 0.9 | GO:0046597 | negative regulation of viral entry into host cell(GO:0046597) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.2 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 1.6 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.1 | 1.1 | GO:0071818 | BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379) |
| 0.0 | 1.1 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.1 | 1.0 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.1 | 0.8 | GO:0071817 | MMXD complex(GO:0071817) |
| 0.0 | 0.8 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.0 | 0.7 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 0.7 | GO:0005605 | basal lamina(GO:0005605) |
| 0.2 | 0.6 | GO:0005584 | collagen type I trimer(GO:0005584) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.1 | 1.4 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.0 | 1.2 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
| 0.2 | 1.0 | GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) |
| 0.0 | 1.0 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.2 | 0.9 | GO:0015018 | galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018) |
| 0.1 | 0.9 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
| 0.0 | 0.9 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.0 | 0.9 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.3 | 0.8 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.0 | 1.2 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 1.1 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 1.1 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.0 | 0.8 | PID S1P S1P3 PATHWAY | S1P3 pathway |
| 0.0 | 0.8 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 0.7 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 0.6 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 0.5 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 0.4 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.5 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 1.4 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 1.1 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.0 | 1.0 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.0 | 0.9 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 0.8 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.0 | 0.8 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.0 | 0.7 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.0 | 0.7 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 0.7 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |