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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for ETS1
Z-value: 1.30
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Transcription factors associated with ETS1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ETS1 | hg19_v2_chr11_-_128392085_128392232 | -0.70 | 1.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ETS1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | GO:0050855 | regulation of B cell receptor signaling pathway(GO:0050855) |
| 0.0 | 2.1 | GO:0007338 | single fertilization(GO:0007338) |
| 0.1 | 1.5 | GO:1902412 | regulation of mitotic cytokinesis(GO:1902412) |
| 0.1 | 1.5 | GO:0045722 | positive regulation of gluconeogenesis(GO:0045722) |
| 0.1 | 1.2 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 0.1 | 1.1 | GO:0019276 | UDP-N-acetylgalactosamine metabolic process(GO:0019276) |
| 0.2 | 1.0 | GO:0003366 | cell-matrix adhesion involved in ameboidal cell migration(GO:0003366) |
| 0.1 | 0.9 | GO:0031666 | positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666) |
| 0.1 | 0.9 | GO:0010993 | regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994) |
| 0.1 | 0.9 | GO:0019336 | phenol-containing compound catabolic process(GO:0019336) catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.4 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.1 | 1.6 | GO:0000235 | astral microtubule(GO:0000235) aster(GO:0005818) |
| 0.0 | 1.3 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.1 | 1.1 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
| 0.0 | 1.1 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.2 | 1.0 | GO:0034669 | integrin alpha4-beta7 complex(GO:0034669) |
| 0.1 | 0.8 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.0 | 0.8 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.1 | 0.7 | GO:0071598 | neuronal ribonucleoprotein granule(GO:0071598) |
| 0.2 | 0.6 | GO:0005953 | CAAX-protein geranylgeranyltransferase complex(GO:0005953) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | GO:0051721 | protein phosphatase 2A binding(GO:0051721) |
| 0.4 | 1.1 | GO:0035248 | alpha-1,4-N-acetylgalactosaminyltransferase activity(GO:0035248) |
| 0.1 | 0.9 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 0.0 | 0.9 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.0 | 0.9 | GO:0005521 | lamin binding(GO:0005521) |
| 0.1 | 0.8 | GO:0001875 | lipopolysaccharide receptor activity(GO:0001875) |
| 0.1 | 0.8 | GO:0043426 | MRF binding(GO:0043426) |
| 0.0 | 0.8 | GO:0008409 | 5'-3' exonuclease activity(GO:0008409) |
| 0.1 | 0.7 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.1 | 0.7 | GO:0038051 | glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 1.0 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.0 | 1.0 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 1.0 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.9 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 0.9 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.0 | 0.8 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.0 | 0.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.5 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 0.5 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.0 | 1.3 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.0 | 1.0 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.0 | 1.0 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 1.0 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 1.0 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 0.9 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.0 | 0.7 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |
| 0.0 | 0.7 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.0 | 0.6 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |