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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for ERG
Z-value: 1.40
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Transcription factors associated with ERG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ERG | hg19_v2_chr21_-_40033618_40033712 | -0.63 | 1.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_153044083 Show fit | 2.23 |
ENST00000341611.2
|
small proline-rich protein 2B |
|
| chr22_+_27068766 Show fit | 2.21 |
ENST00000435162.1
ENST00000437071.1 ENST00000440816.1 ENST00000421253.1 |
CTA-211A9.5 |
|
| chr4_-_74864386 Show fit | 2.01 |
ENST00000296027.4
|
chemokine (C-X-C motif) ligand 5 |
|
| chr1_-_153066998 Show fit | 2.00 |
ENST00000368750.3
|
small proline-rich protein 2E |
|
| chr1_-_153113927 Show fit | 1.45 |
ENST00000368752.4
|
small proline-rich protein 2B |
|
| chr12_+_113344811 Show fit | 1.38 |
ENST00000551241.1
ENST00000553185.1 ENST00000550689.1 |
2'-5'-oligoadenylate synthetase 1, 40/46kDa |
|
| chr1_+_153330322 Show fit | 1.32 |
ENST00000368738.3
|
S100 calcium binding protein A9 |
|
| chr2_+_228678550 Show fit | 1.26 |
ENST00000409189.3
ENST00000358813.4 |
chemokine (C-C motif) ligand 20 |
|
| chr5_+_131409476 Show fit | 1.14 |
ENST00000296871.2
|
colony stimulating factor 2 (granulocyte-macrophage) |
|
| chr2_+_239335636 Show fit | 1.13 |
ENST00000409297.1
|
ankyrin repeat and SOCS box containing 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ERG
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.8 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.0 | 4.0 | GO:0006364 | rRNA processing(GO:0006364) |
| 0.2 | 3.8 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.1 | 3.0 | GO:0003373 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 0.2 | 2.4 | GO:1904327 | protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379) |
| 0.1 | 2.1 | GO:0071801 | regulation of podosome assembly(GO:0071801) |
| 0.0 | 2.1 | GO:0042058 | regulation of epidermal growth factor receptor signaling pathway(GO:0042058) |
| 0.1 | 1.9 | GO:0016226 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
| 0.0 | 1.9 | GO:0002223 | stimulatory C-type lectin receptor signaling pathway(GO:0002223) |
| 0.3 | 1.8 | GO:0010989 | negative regulation of low-density lipoprotein particle clearance(GO:0010989) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.8 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 4.0 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 2.8 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.1 | 2.6 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.2 | 2.4 | GO:0071818 | BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379) |
| 0.0 | 2.4 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 2.1 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.1 | 2.0 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.0 | 1.5 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 1.4 | GO:0005796 | Golgi lumen(GO:0005796) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.3 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.0 | 3.2 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 3.1 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.2 | 2.8 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.1 | 2.4 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.0 | 2.3 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.0 | 2.1 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.3 | 2.0 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.0 | 1.8 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.1 | 1.6 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.7 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 2.8 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 2.3 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.0 | 2.2 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.0 | 2.0 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 2.0 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 1.9 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 1.9 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 1.8 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.0 | 1.4 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.3 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 4.2 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 2.9 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 2.6 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 2.6 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 2.3 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 2.2 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 2.1 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 2.0 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.1 | 1.8 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |