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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for EN1_ESX1_GBX1

Z-value: 0.91

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Transcription factors associated with EN1_ESX1_GBX1

Gene Symbol Gene ID Gene Info
EN1
ENSG00000163064.6 engrailed homeobox 1
ESX1
ENSG00000123576.5 ESX homeobox 1
GBX1
ENSG00000164900.4 gastrulation brain homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ESX1hg19_v2_chrX_-_103499602_1034996170.522.9e-01Click!

Activity profile of EN1_ESX1_GBX1 motif

Sorted Z-values of EN1_ESX1_GBX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_27998689 1.14 ENST00000339145.4
ENST00000362020.4
ENST00000361157.6
IFI6
interferon, alpha-inducible protein 6
chr12_+_78359999 0.87 ENST00000550503.1
NAV3
neuron navigator 3
chr7_+_37723336 0.80 ENST00000450180.1
GPR141
G protein-coupled receptor 141
chr5_+_66300464 0.75 ENST00000436277.1
MAST4
microtubule associated serine/threonine kinase family member 4
chr15_+_63188009 0.66 ENST00000557900.1
RP11-1069G10.2
RP11-1069G10.2
chr12_-_89746264 0.55 ENST00000548755.1
DUSP6
dual specificity phosphatase 6
chr11_-_31531121 0.54 ENST00000532287.1
ENST00000526776.1
ENST00000534812.1
ENST00000529749.1
ENST00000278200.1
ENST00000530023.1
ENST00000533642.1
IMMP1L
IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chrX_+_107288280 0.48 ENST00000458383.1
VSIG1
V-set and immunoglobulin domain containing 1
chr17_+_62223320 0.42 ENST00000580828.1
ENST00000582965.1
SNORA76
small nucleolar RNA, H/ACA box 76
chr2_+_90248739 0.42 ENST00000468879.1
IGKV1D-43
immunoglobulin kappa variable 1D-43
chr5_-_150473127 0.42 ENST00000521001.1
TNIP1
TNFAIP3 interacting protein 1
chr7_-_99716914 0.42 ENST00000431404.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr4_-_57547870 0.41 ENST00000381260.3
ENST00000420433.1
ENST00000554144.1
ENST00000557328.1
HOPX
HOP homeobox
chr19_-_51522955 0.40 ENST00000358789.3
KLK10
kallikrein-related peptidase 10
chr6_-_30685214 0.37 ENST00000425072.1
MDC1
mediator of DNA-damage checkpoint 1
chr1_-_21620877 0.37 ENST00000527991.1
ECE1
endothelin converting enzyme 1
chr2_+_149402989 0.36 ENST00000397424.2
EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr6_-_116833500 0.36 ENST00000356128.4
TRAPPC3L
trafficking protein particle complex 3-like
chr5_+_66300446 0.36 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr11_+_77532233 0.35 ENST00000525409.1
AAMDC
adipogenesis associated, Mth938 domain containing
chr17_-_57229155 0.35 ENST00000584089.1
SKA2
spindle and kinetochore associated complex subunit 2
chr7_-_33102338 0.34 ENST00000610140.1
NT5C3A
5'-nucleotidase, cytosolic IIIA
chr7_+_129984630 0.33 ENST00000355388.3
ENST00000497503.1
ENST00000463587.1
ENST00000461828.1
ENST00000494311.1
ENST00000466363.2
ENST00000485477.1
ENST00000431780.2
ENST00000474905.1
CPA5
carboxypeptidase A5
chr17_-_38859996 0.33 ENST00000264651.2
KRT24
keratin 24
chr9_-_5339873 0.32 ENST00000223862.1
ENST00000223858.4
RLN1
relaxin 1
chr1_-_152386732 0.31 ENST00000271835.3
CRNN
cornulin
chr16_-_55866997 0.31 ENST00000360526.3
ENST00000361503.4
CES1
carboxylesterase 1
chr12_-_52828147 0.31 ENST00000252245.5
KRT75
keratin 75
chr22_+_46476192 0.31 ENST00000443490.1
FLJ27365
hsa-mir-4763
chr22_+_38054721 0.31 ENST00000215904.6
PDXP
pyridoxal (pyridoxine, vitamin B6) phosphatase
chr17_-_38928414 0.31 ENST00000335552.4
KRT26
keratin 26
chr4_-_109541539 0.31 ENST00000509984.1
ENST00000507248.1
ENST00000506795.1
RPL34-AS1
RPL34 antisense RNA 1 (head to head)
chr20_+_55967129 0.30 ENST00000371219.2
RBM38
RNA binding motif protein 38
chr8_-_42234745 0.30 ENST00000220812.2
DKK4
dickkopf WNT signaling pathway inhibitor 4
chr6_-_30684898 0.29 ENST00000422266.1
ENST00000416571.1
MDC1
mediator of DNA-damage checkpoint 1
chr19_+_48949087 0.28 ENST00000598711.1
GRWD1
glutamate-rich WD repeat containing 1
chr13_-_36788718 0.27 ENST00000317764.6
ENST00000379881.3
SOHLH2
spermatogenesis and oogenesis specific basic helix-loop-helix 2
chr9_+_139780942 0.27 ENST00000247668.2
ENST00000359662.3
TRAF2
TNF receptor-associated factor 2
chr4_+_105828537 0.27 ENST00000515649.1
RP11-556I14.1
RP11-556I14.1
chr16_+_53133070 0.26 ENST00000565832.1
CHD9
chromodomain helicase DNA binding protein 9
chr4_-_105416039 0.26 ENST00000394767.2
CXXC4
CXXC finger protein 4
chr12_-_10978957 0.26 ENST00000240619.2
TAS2R10
taste receptor, type 2, member 10
chr12_-_94673956 0.26 ENST00000551941.1
RP11-1105G2.3
Uncharacterized protein
chr6_-_26250835 0.26 ENST00000446824.2
HIST1H3F
histone cluster 1, H3f
chr2_+_89952792 0.26 ENST00000390265.2
IGKV1D-33
immunoglobulin kappa variable 1D-33
chr7_-_33102399 0.25 ENST00000242210.7
NT5C3A
5'-nucleotidase, cytosolic IIIA
chr1_-_21625486 0.25 ENST00000481130.2
ECE1
endothelin converting enzyme 1
chr7_-_92777606 0.25 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
SAMD9L
sterile alpha motif domain containing 9-like
chr4_-_57547454 0.24 ENST00000556376.2
HOPX
HOP homeobox
chr2_+_234826016 0.24 ENST00000324695.4
ENST00000433712.2
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr8_+_119294456 0.24 ENST00000366457.2
AC023590.1
Uncharacterized protein
chr16_+_103816 0.24 ENST00000383018.3
ENST00000417493.1
SNRNP25
small nuclear ribonucleoprotein 25kDa (U11/U12)
chr19_+_4007644 0.24 ENST00000262971.2
PIAS4
protein inhibitor of activated STAT, 4
chr21_-_15918618 0.23 ENST00000400564.1
ENST00000400566.1
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr6_+_55192267 0.23 ENST00000340465.2
GFRAL
GDNF family receptor alpha like
chr6_-_167040693 0.23 ENST00000366863.2
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr20_+_3776371 0.23 ENST00000245960.5
CDC25B
cell division cycle 25B
chrX_-_100129128 0.22 ENST00000372960.4
ENST00000372964.1
ENST00000217885.5
NOX1
NADPH oxidase 1
chr1_+_244515930 0.22 ENST00000366537.1
ENST00000308105.4
C1orf100
chromosome 1 open reading frame 100
chr4_+_147145709 0.22 ENST00000504313.1
RP11-6L6.2
Uncharacterized protein
chr12_+_26348246 0.22 ENST00000422622.2
SSPN
sarcospan
chr1_-_36916011 0.22 ENST00000356637.5
ENST00000354267.3
ENST00000235532.5
OSCP1
organic solute carrier partner 1
chr18_+_32556892 0.21 ENST00000591734.1
ENST00000413393.1
ENST00000589180.1
ENST00000587359.1
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr6_+_3259148 0.21 ENST00000419065.2
ENST00000473000.2
ENST00000451246.2
ENST00000454610.2
PSMG4
proteasome (prosome, macropain) assembly chaperone 4
chr8_-_42698292 0.21 ENST00000529779.1
THAP1
THAP domain containing, apoptosis associated protein 1
chr5_-_147286065 0.21 ENST00000318315.4
ENST00000515291.1
C5orf46
chromosome 5 open reading frame 46
chr2_-_224467002 0.20 ENST00000421386.1
ENST00000433889.1
SCG2
secretogranin II
chr19_-_7968427 0.20 ENST00000539278.1
AC010336.1
Uncharacterized protein
chr19_+_48949030 0.20 ENST00000253237.5
GRWD1
glutamate-rich WD repeat containing 1
chr1_-_235098935 0.19 ENST00000423175.1
RP11-443B7.1
RP11-443B7.1
chr7_-_99716952 0.19 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr6_-_26032288 0.19 ENST00000244661.2
HIST1H3B
histone cluster 1, H3b
chr3_+_63805017 0.19 ENST00000295896.8
C3orf49
chromosome 3 open reading frame 49
chr8_-_71157595 0.18 ENST00000519724.1
NCOA2
nuclear receptor coactivator 2
chr9_-_5304432 0.18 ENST00000416837.1
ENST00000308420.3
RLN2
relaxin 2
chr3_-_195538760 0.18 ENST00000475231.1
MUC4
mucin 4, cell surface associated
chr22_-_42765174 0.18 ENST00000432473.1
ENST00000412060.1
ENST00000424852.1
Z83851.1
Z83851.1
chr19_-_41870026 0.17 ENST00000243578.3
B9D2
B9 protein domain 2
chr7_-_72971934 0.17 ENST00000411832.1
BCL7B
B-cell CLL/lymphoma 7B
chr19_+_39421556 0.17 ENST00000407800.2
ENST00000402029.3
MRPS12
mitochondrial ribosomal protein S12
chr14_-_37051798 0.17 ENST00000258829.5
NKX2-8
NK2 homeobox 8
chr4_-_19458597 0.17 ENST00000505347.1
RP11-3J1.1
RP11-3J1.1
chr17_+_43238438 0.17 ENST00000593138.1
ENST00000586681.1
HEXIM2
hexamethylene bis-acetamide inducible 2
chr16_-_4039001 0.17 ENST00000576936.1
ADCY9
adenylate cyclase 9
chr1_+_153747746 0.17 ENST00000368661.3
SLC27A3
solute carrier family 27 (fatty acid transporter), member 3
chr12_+_7013897 0.16 ENST00000007969.8
ENST00000323702.5
LRRC23
leucine rich repeat containing 23
chr20_+_43990576 0.16 ENST00000372727.1
ENST00000414310.1
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr2_+_196313239 0.16 ENST00000413290.1
AC064834.1
AC064834.1
chr19_-_54618650 0.16 ENST00000391757.1
TFPT
TCF3 (E2A) fusion partner (in childhood Leukemia)
chr12_+_72058130 0.16 ENST00000547843.1
THAP2
THAP domain containing, apoptosis associated protein 2
chr19_-_52307357 0.16 ENST00000594900.1
FPR1
formyl peptide receptor 1
chr6_+_34204642 0.16 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1
high mobility group AT-hook 1
chr2_-_203735484 0.15 ENST00000420558.1
ENST00000418208.1
ICA1L
islet cell autoantigen 1,69kDa-like
chr11_-_60010556 0.15 ENST00000427611.2
MS4A4E
membrane-spanning 4-domains, subfamily A, member 4E
chr8_-_86290333 0.15 ENST00000521846.1
ENST00000523022.1
ENST00000524324.1
ENST00000519991.1
ENST00000520663.1
ENST00000517590.1
ENST00000522579.1
ENST00000522814.1
ENST00000522662.1
ENST00000523858.1
ENST00000519129.1
CA1
carbonic anhydrase I
chr19_-_10227503 0.15 ENST00000593054.1
EIF3G
eukaryotic translation initiation factor 3, subunit G
chr12_-_56693758 0.15 ENST00000547298.1
ENST00000551936.1
ENST00000551253.1
ENST00000551473.1
CS
citrate synthase
chr8_-_19614810 0.14 ENST00000524213.1
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr1_-_36915880 0.14 ENST00000445843.3
OSCP1
organic solute carrier partner 1
chr3_+_173116225 0.14 ENST00000457714.1
NLGN1
neuroligin 1
chr5_+_174151536 0.14 ENST00000239243.6
ENST00000507785.1
MSX2
msh homeobox 2
chr17_+_59489112 0.14 ENST00000335108.2
C17orf82
chromosome 17 open reading frame 82
chr3_-_195538728 0.14 ENST00000349607.4
ENST00000346145.4
MUC4
mucin 4, cell surface associated
chr19_-_3557570 0.14 ENST00000355415.2
MFSD12
major facilitator superfamily domain containing 12
chr22_-_32767017 0.14 ENST00000400234.1
RFPL3S
RFPL3 antisense
chr12_-_28123206 0.14 ENST00000542963.1
ENST00000535992.1
PTHLH
parathyroid hormone-like hormone
chr16_-_2264779 0.14 ENST00000333503.7
PGP
phosphoglycolate phosphatase
chr20_+_43538692 0.14 ENST00000217074.4
ENST00000255136.3
PABPC1L
poly(A) binding protein, cytoplasmic 1-like
chr17_+_42785976 0.14 ENST00000393547.2
ENST00000398338.3
DBF4B
DBF4 homolog B (S. cerevisiae)
chr12_-_86650077 0.13 ENST00000552808.2
ENST00000547225.1
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr3_-_108248169 0.13 ENST00000273353.3
MYH15
myosin, heavy chain 15
chr20_+_43538756 0.13 ENST00000537323.1
ENST00000217073.2
PABPC1L
poly(A) binding protein, cytoplasmic 1-like
chr1_+_186369704 0.13 ENST00000574641.1
OCLM
oculomedin
chr9_-_131486367 0.13 ENST00000372663.4
ENST00000406904.2
ENST00000452105.1
ENST00000372672.2
ENST00000372667.5
ZDHHC12
zinc finger, DHHC-type containing 12
chrX_-_153602991 0.13 ENST00000369850.3
ENST00000422373.1
FLNA
filamin A, alpha
chr11_-_40315640 0.13 ENST00000278198.2
LRRC4C
leucine rich repeat containing 4C
chr12_-_6233828 0.13 ENST00000572068.1
ENST00000261405.5
VWF
von Willebrand factor
chr17_-_28661065 0.13 ENST00000328886.4
ENST00000538566.2
TMIGD1
transmembrane and immunoglobulin domain containing 1
chr1_+_32538520 0.13 ENST00000438825.1
ENST00000456834.2
ENST00000373634.4
ENST00000427288.1
TMEM39B
transmembrane protein 39B
chr14_+_101359265 0.13 ENST00000599197.1
AL117190.3
Esophagus cancer-related gene-2 interaction susceptibility protein; Uncharacterized protein
chr12_+_26348429 0.12 ENST00000242729.2
SSPN
sarcospan
chr11_-_26593677 0.12 ENST00000527569.1
MUC15
mucin 15, cell surface associated
chr4_-_89205350 0.12 ENST00000509340.1
PPM1K
protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr5_+_38445641 0.12 ENST00000397210.3
ENST00000506135.1
ENST00000508131.1
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr14_-_45252031 0.12 ENST00000556405.1
RP11-398E10.1
RP11-398E10.1
chr1_-_242612779 0.12 ENST00000427495.1
PLD5
phospholipase D family, member 5
chr5_-_13944652 0.12 ENST00000265104.4
DNAH5
dynein, axonemal, heavy chain 5
chr5_+_53686658 0.12 ENST00000512618.1
LINC01033
long intergenic non-protein coding RNA 1033
chr7_-_99717463 0.12 ENST00000437822.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr19_-_59084647 0.12 ENST00000594234.1
ENST00000596039.1
MZF1
myeloid zinc finger 1
chrX_+_591524 0.12 ENST00000554971.1
ENST00000381575.1
SHOX
short stature homeobox
chr4_-_138453606 0.12 ENST00000412923.2
ENST00000344876.4
ENST00000507846.1
ENST00000510305.1
PCDH18
protocadherin 18
chr7_-_92107229 0.12 ENST00000603053.1
ERVW-1
endogenous retrovirus group W, member 1
chr2_+_152214098 0.12 ENST00000243347.3
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr7_-_78400598 0.12 ENST00000536571.1
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr16_+_58010339 0.12 ENST00000290871.5
ENST00000441824.2
TEPP
testis, prostate and placenta expressed
chr11_+_101918153 0.12 ENST00000434758.2
ENST00000526781.1
ENST00000534360.1
C11orf70
chromosome 11 open reading frame 70
chr11_+_818902 0.12 ENST00000336615.4
PNPLA2
patatin-like phospholipase domain containing 2
chr17_+_19091325 0.12 ENST00000584923.1
SNORD3A
small nucleolar RNA, C/D box 3A
chr6_+_4087664 0.11 ENST00000430835.2
C6orf201
chromosome 6 open reading frame 201
chr12_-_51422017 0.11 ENST00000394904.3
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
chr3_+_111717511 0.11 ENST00000478951.1
ENST00000393917.2
TAGLN3
transgelin 3
chr1_-_201140673 0.11 ENST00000367333.2
TMEM9
transmembrane protein 9
chr3_-_98235962 0.11 ENST00000513873.1
CLDND1
claudin domain containing 1
chr4_-_89951028 0.11 ENST00000506913.1
FAM13A
family with sequence similarity 13, member A
chr1_+_28261533 0.11 ENST00000411604.1
ENST00000373888.4
SMPDL3B
sphingomyelin phosphodiesterase, acid-like 3B
chr14_-_38064198 0.11 ENST00000250448.2
FOXA1
forkhead box A1
chr22_-_32766972 0.11 ENST00000382084.4
ENST00000382086.2
RFPL3S
RFPL3 antisense
chr12_-_16759440 0.11 ENST00000537304.1
LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_+_14927270 0.11 ENST00000544848.1
H2AFJ
H2A histone family, member J
chr5_+_133562095 0.11 ENST00000602919.1
CTD-2410N18.3
CTD-2410N18.3
chr15_-_31393910 0.11 ENST00000397795.2
ENST00000256552.6
ENST00000559179.1
TRPM1
transient receptor potential cation channel, subfamily M, member 1
chr4_-_143226979 0.11 ENST00000514525.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr7_-_99716940 0.11 ENST00000440225.1
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr4_-_143227088 0.11 ENST00000511838.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr5_+_159343688 0.11 ENST00000306675.3
ADRA1B
adrenoceptor alpha 1B
chr5_+_52776228 0.11 ENST00000256759.3
FST
follistatin
chr1_-_22215192 0.11 ENST00000374673.3
HSPG2
heparan sulfate proteoglycan 2
chr6_+_31783291 0.11 ENST00000375651.5
ENST00000608703.1
ENST00000458062.2
HSPA1A
heat shock 70kDa protein 1A
chr1_+_209878182 0.11 ENST00000367027.3
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr19_+_45394477 0.11 ENST00000252487.5
ENST00000405636.2
ENST00000592434.1
ENST00000426677.2
ENST00000589649.1
TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr16_+_53412368 0.10 ENST00000565189.1
RP11-44F14.2
RP11-44F14.2
chr4_+_89206076 0.10 ENST00000500009.2
RP11-10L7.1
RP11-10L7.1
chr3_+_138340049 0.10 ENST00000464668.1
FAIM
Fas apoptotic inhibitory molecule
chr16_+_14280564 0.10 ENST00000572567.1
MKL2
MKL/myocardin-like 2
chr14_-_104181771 0.10 ENST00000554913.1
ENST00000554974.1
ENST00000553361.1
ENST00000555055.1
ENST00000555964.1
ENST00000556682.1
ENST00000445556.1
ENST00000553332.1
ENST00000352127.7
XRCC3
X-ray repair complementing defective repair in Chinese hamster cells 3
chr5_+_52776449 0.10 ENST00000396947.3
FST
follistatin
chr17_+_79650962 0.10 ENST00000329138.4
HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr17_-_73937116 0.10 ENST00000586717.1
ENST00000389570.4
ENST00000319129.5
FBF1
Fas (TNFRSF6) binding factor 1
chr17_+_79651007 0.10 ENST00000572392.1
ENST00000577012.1
HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr7_-_100860851 0.10 ENST00000223127.3
PLOD3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr4_+_76439095 0.10 ENST00000506261.1
THAP6
THAP domain containing 6
chr16_+_12059091 0.10 ENST00000562385.1
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr10_-_135379132 0.10 ENST00000343131.5
SYCE1
synaptonemal complex central element protein 1
chrM_+_8527 0.10 ENST00000361899.2
MT-ATP6
mitochondrially encoded ATP synthase 6
chr8_-_145159083 0.10 ENST00000398712.2
SHARPIN
SHANK-associated RH domain interactor
chr10_-_104866395 0.10 ENST00000458345.1
NT5C2
5'-nucleotidase, cytosolic II
chr5_+_172068232 0.10 ENST00000520919.1
ENST00000522853.1
ENST00000369800.5
NEURL1B
neuralized E3 ubiquitin protein ligase 1B
chr4_+_77356248 0.10 ENST00000296043.6
SHROOM3
shroom family member 3
chr19_+_3762703 0.10 ENST00000589174.1
MRPL54
mitochondrial ribosomal protein L54
chr11_-_71823266 0.10 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
ANAPC15
anaphase promoting complex subunit 15
chr2_+_143635067 0.10 ENST00000264170.4
KYNU
kynureninase
chr14_+_23709555 0.10 ENST00000430154.2
C14orf164
chromosome 14 open reading frame 164
chr14_+_29236269 0.10 ENST00000313071.4
FOXG1
forkhead box G1
chrX_+_135730297 0.09 ENST00000370629.2
CD40LG
CD40 ligand
chr6_-_26199499 0.09 ENST00000377831.5
HIST1H3D
histone cluster 1, H3d
chr1_+_32538492 0.09 ENST00000336294.5
TMEM39B
transmembrane protein 39B
chr1_-_159832438 0.09 ENST00000368100.1
VSIG8
V-set and immunoglobulin domain containing 8
chr2_+_149974684 0.09 ENST00000450639.1
LYPD6B
LY6/PLAUR domain containing 6B
chr5_+_140557371 0.09 ENST00000239444.2
PCDHB8
protocadherin beta 8
chr11_-_64684672 0.09 ENST00000377264.3
ENST00000421419.2
ATG2A
autophagy related 2A
chr5_+_140529630 0.09 ENST00000543635.1
PCDHB6
protocadherin beta 6
chr14_-_24584138 0.09 ENST00000558280.1
ENST00000561028.1
NRL
neural retina leucine zipper
chr18_-_67624412 0.09 ENST00000580335.1
CD226
CD226 molecule
chr8_-_66474884 0.09 ENST00000520902.1
CTD-3025N20.2
CTD-3025N20.2
chr4_-_103749205 0.09 ENST00000508249.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr11_+_24518723 0.09 ENST00000336930.6
ENST00000529015.1
ENST00000533227.1
LUZP2
leucine zipper protein 2
chr11_-_63376013 0.09 ENST00000540943.1
PLA2G16
phospholipase A2, group XVI
chr1_-_50889155 0.09 ENST00000404795.3
DMRTA2
DMRT-like family A2
chr20_-_50419055 0.09 ENST00000217086.4
SALL4
spalt-like transcription factor 4

Network of associatons between targets according to the STRING database.

First level regulatory network of EN1_ESX1_GBX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.1 1.1 GO:1904180 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.1 0.6 GO:0034959 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.1 0.3 GO:0031247 actin rod assembly(GO:0031247)
0.1 0.4 GO:0052250 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.1 0.3 GO:0090119 vesicle-mediated cholesterol transport(GO:0090119)
0.1 0.1 GO:0051795 positive regulation of catagen(GO:0051795)
0.1 0.3 GO:1903721 regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721)
0.1 0.3 GO:0045113 regulation of integrin biosynthetic process(GO:0045113) positive regulation of integrin biosynthetic process(GO:0045726)
0.1 0.2 GO:1904017 cellular response to Thyroglobulin triiodothyronine(GO:1904017)
0.1 0.5 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.1 0.1 GO:0070434 positive regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070426) positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070434)
0.0 0.1 GO:0099543 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.0 0.7 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 0.1 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.0 0.3 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.3 GO:0051799 negative regulation of hair follicle development(GO:0051799)
0.0 0.2 GO:0050955 thermoception(GO:0050955)
0.0 0.1 GO:0071140 resolution of recombination intermediates(GO:0071139) resolution of mitotic recombination intermediates(GO:0071140)
0.0 0.1 GO:0006114 glycerol biosynthetic process(GO:0006114)
0.0 0.2 GO:1902231 positive regulation of keratinocyte apoptotic process(GO:1902174) positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0 0.1 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.0 0.2 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.0 0.7 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.1 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.1 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.0 0.7 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.0 0.7 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 0.1 GO:0046946 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.0 0.1 GO:0002729 positive regulation of natural killer cell cytokine production(GO:0002729)
0.0 0.1 GO:0030070 insulin processing(GO:0030070)
0.0 0.1 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
0.0 0.1 GO:2001190 positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.0 0.1 GO:0007468 regulation of rhodopsin gene expression(GO:0007468) positive regulation of rhodopsin gene expression(GO:0045872)
0.0 0.0 GO:2000118 regulation of sodium-dependent phosphate transport(GO:2000118)
0.0 0.3 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.1 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.0 0.1 GO:0006434 seryl-tRNA aminoacylation(GO:0006434)
0.0 0.1 GO:0015692 lead ion transport(GO:0015692)
0.0 0.3 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.1 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.0 0.1 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.0 0.1 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.0 GO:0003257 positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation(GO:0003257) positive regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901228)
0.0 0.1 GO:0002326 B cell lineage commitment(GO:0002326)
0.0 0.3 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.2 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.1 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.0 0.1 GO:0071934 thiamine transmembrane transport(GO:0071934)
0.0 0.2 GO:0007144 female meiosis I(GO:0007144)
0.0 0.1 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.0 0.1 GO:0060809 chemoattraction of serotonergic neuron axon(GO:0036517) lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599) mesodermal to mesenchymal transition involved in gastrulation(GO:0060809) planar cell polarity pathway involved in outflow tract morphogenesis(GO:0061347) planar cell polarity pathway involved in ventricular septum morphogenesis(GO:0061348) planar cell polarity pathway involved in cardiac right atrium morphogenesis(GO:0061349) planar cell polarity pathway involved in cardiac muscle tissue morphogenesis(GO:0061350) planar cell polarity pathway involved in pericardium morphogenesis(GO:0061354) chemoattraction of axon(GO:0061642) negative regulation of cell proliferation in midbrain(GO:1904934) planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation(GO:1904955)
0.0 0.1 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.0 0.1 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.2 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0 0.5 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 0.1 GO:0048241 epinephrine transport(GO:0048241)
0.0 0.0 GO:0003219 cardiac right ventricle formation(GO:0003219)
0.0 0.0 GO:1904252 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) negative regulation of bile acid biosynthetic process(GO:0070858) acinar cell differentiation(GO:0090425) negative regulation of bile acid metabolic process(GO:1904252) positive regulation of forebrain neuron differentiation(GO:2000979)
0.0 0.1 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.0 0.1 GO:0093001 glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001)
0.0 0.0 GO:0006550 isoleucine catabolic process(GO:0006550)
0.0 0.1 GO:1900133 regulation of renin secretion into blood stream(GO:1900133)
0.0 0.1 GO:0030309 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0 0.0 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.0 0.0 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.1 GO:0008343 adult feeding behavior(GO:0008343)
0.0 0.2 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.3 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.1 GO:0048254 snoRNA localization(GO:0048254)
0.0 0.2 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 0.3 GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway(GO:0071880)
0.0 0.0 GO:0002934 desmosome organization(GO:0002934)
0.0 0.2 GO:1903543 positive regulation of exosomal secretion(GO:1903543)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 0.6 GO:0031302 intrinsic component of endosome membrane(GO:0031302)
0.1 0.3 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.0 0.1 GO:0035841 new growing cell tip(GO:0035841)
0.0 0.4 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.8 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.1 GO:0031523 Myb complex(GO:0031523)
0.0 0.1 GO:0044305 calyx of Held(GO:0044305)
0.0 0.2 GO:0033565 ESCRT-0 complex(GO:0033565)
0.0 0.1 GO:0036338 viral envelope(GO:0019031) viral membrane(GO:0036338)
0.0 0.0 GO:0005683 U7 snRNP(GO:0005683)
0.0 0.1 GO:0070826 paraferritin complex(GO:0070826)
0.0 0.8 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.4 GO:0070938 contractile ring(GO:0070938)
0.0 0.1 GO:0000801 central element(GO:0000801)
0.0 0.1 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.3 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.1 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.0 0.1 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.3 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.2 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.1 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.0 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.0 0.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0005174 CD40 receptor binding(GO:0005174)
0.1 0.6 GO:0008665 2'-phosphotransferase activity(GO:0008665)
0.1 0.4 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.1 0.3 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
0.1 0.3 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.1 0.2 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.1 1.0 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.3 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.0 0.1 GO:0000994 RNA polymerase III core binding(GO:0000994)
0.0 0.2 GO:0017161 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.0 0.1 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.0 0.1 GO:0050146 nucleoside phosphotransferase activity(GO:0050146)
0.0 0.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.1 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.2 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.1 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823) procollagen galactosyltransferase activity(GO:0050211)
0.0 0.3 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.1 GO:1901375 acetylcholine transmembrane transporter activity(GO:0005277) acetate ester transmembrane transporter activity(GO:1901375)
0.0 0.2 GO:0004982 N-formyl peptide receptor activity(GO:0004982)
0.0 0.1 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.1 GO:0004936 alpha-adrenergic receptor activity(GO:0004936)
0.0 0.1 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.0 0.5 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.1 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.0 0.1 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.0 0.1 GO:0016250 N-sulfoglucosamine sulfohydrolase activity(GO:0016250) hydrolase activity, acting on acid sulfur-nitrogen bonds(GO:0016826)
0.0 0.1 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.0 0.1 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.1 GO:0015087 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.0 0.2 GO:0004064 arylesterase activity(GO:0004064)
0.0 0.1 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.1 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.0 0.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.1 GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0 0.1 GO:1902379 receptor tyrosine kinase-like orphan receptor binding(GO:0005115) chemoattractant activity involved in axon guidance(GO:1902379)
0.0 0.0 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.0 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0 0.2 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.1 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0 0.1 GO:0050115 myosin-light-chain-phosphatase activity(GO:0050115)
0.0 0.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.6 GO:0017046 peptide hormone binding(GO:0017046)
0.0 0.1 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.2 GO:0048185 activin binding(GO:0048185)
0.0 0.1 GO:0031779 melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0 0.0 GO:0071209 U7 snRNA binding(GO:0071209)
0.0 0.1 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.3 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.9 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.2 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.6 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.5 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 1.1 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.3 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.2 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.2 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.7 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.2 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.3 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets