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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for ELF3_EHF
Z-value: 0.82
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Transcription factors associated with ELF3_EHF
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EHF | hg19_v2_chr11_+_34642656_34642682 | -0.54 | 2.7e-01 | Click! |
| ELF3 | hg19_v2_chr1_+_201979645_201979721 | 0.49 | 3.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_242913327 Show fit | 0.93 |
ENST00000426962.1
|
AC093642.3 |
|
| chr8_+_182422 Show fit | 0.66 |
ENST00000518414.1
ENST00000521270.1 ENST00000518320.2 |
zinc finger protein 596 |
|
| chr19_+_41497178 Show fit | 0.47 |
ENST00000324071.4
|
cytochrome P450, family 2, subfamily B, polypeptide 6 |
|
| chr13_-_114103443 Show fit | 0.42 |
ENST00000356501.4
ENST00000413169.2 |
ADP-ribosylhydrolase like 1 |
|
| chr5_-_110074603 Show fit | 0.38 |
ENST00000515278.2
|
transmembrane protein 232 |
|
| chr12_-_58329888 Show fit | 0.38 |
ENST00000546580.1
|
RP11-620J15.3 |
|
| chr5_+_172484377 Show fit | 0.35 |
ENST00000523161.1
|
CREB3 regulatory factor |
|
| chr1_-_12679171 Show fit | 0.35 |
ENST00000606790.1
|
RP11-474O21.5 |
|
| chr19_-_45004556 Show fit | 0.33 |
ENST00000587047.1
ENST00000391956.4 ENST00000221327.4 ENST00000586637.1 ENST00000591064.1 ENST00000592529.1 |
zinc finger protein 180 |
|
| chr10_-_22292675 Show fit | 0.31 |
ENST00000376946.1
|
DnaJ (Hsp40) homolog, subfamily C, member 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ELF3_EHF
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | GO:0042737 | drug catabolic process(GO:0042737) |
| 0.0 | 0.6 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
| 0.1 | 0.4 | GO:0038161 | prolactin signaling pathway(GO:0038161) |
| 0.1 | 0.4 | GO:0051725 | protein de-ADP-ribosylation(GO:0051725) |
| 0.0 | 0.4 | GO:0044375 | regulation of peroxisome size(GO:0044375) |
| 0.0 | 0.4 | GO:0060044 | negative regulation of cardiac muscle cell proliferation(GO:0060044) |
| 0.0 | 0.3 | GO:2000567 | memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568) |
| 0.0 | 0.3 | GO:0015871 | choline transport(GO:0015871) |
| 0.0 | 0.2 | GO:0036071 | N-glycan fucosylation(GO:0036071) |
| 0.0 | 0.2 | GO:0036369 | transcription factor catabolic process(GO:0036369) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.0 | 0.3 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 0.1 | 0.2 | GO:0032783 | ELL-EAF complex(GO:0032783) |
| 0.0 | 0.2 | GO:0071001 | U4/U6 snRNP(GO:0071001) |
| 0.0 | 0.2 | GO:0034464 | BBSome(GO:0034464) |
| 0.0 | 0.2 | GO:0030914 | STAGA complex(GO:0030914) |
| 0.0 | 0.2 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.0 | 0.1 | GO:0002945 | cyclin K-CDK13 complex(GO:0002945) |
| 0.0 | 0.1 | GO:0000799 | nuclear condensin complex(GO:0000799) |
| 0.0 | 0.1 | GO:0071006 | U2-type catalytic step 1 spliceosome(GO:0071006) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | GO:0003875 | ADP-ribosylarginine hydrolase activity(GO:0003875) |
| 0.1 | 0.4 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.0 | 0.4 | GO:0008392 | arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392) |
| 0.1 | 0.3 | GO:0061628 | H3K27me3 modified histone binding(GO:0061628) |
| 0.1 | 0.3 | GO:0023025 | MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030) |
| 0.0 | 0.2 | GO:0008424 | glycoprotein 6-alpha-L-fucosyltransferase activity(GO:0008424) alpha-(1->6)-fucosyltransferase activity(GO:0046921) |
| 0.0 | 0.2 | GO:0004362 | glutathione-disulfide reductase activity(GO:0004362) |
| 0.0 | 0.2 | GO:0015204 | urea transmembrane transporter activity(GO:0015204) |
| 0.0 | 0.2 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
| 0.0 | 0.2 | GO:0015220 | choline transmembrane transporter activity(GO:0015220) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.1 | PID AURORA A PATHWAY | Aurora A signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.0 | 0.4 | REACTOME AMINE COMPOUND SLC TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.0 | 0.2 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.0 | 0.1 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.0 | 0.1 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.0 | 0.0 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |