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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for ELF2_GABPA_ELF5
Z-value: 1.74
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Transcription factors associated with ELF2_GABPA_ELF5
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000109381.15 | E74 like ETS transcription factor 2 | |
| ENSG00000154727.6 | GA binding protein transcription factor subunit alpha | |
| ENSG00000135374.5 | E74 like ETS transcription factor 5 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ELF2 | hg19_v2_chr4_-_140098339_140098392 | 0.50 | 3.1e-01 | Click! |
| ELF5 | hg19_v2_chr11_-_34535297_34535317 | 0.48 | 3.4e-01 | Click! |
| GABPA | hg19_v2_chr21_+_27107672_27107698 | 0.03 | 9.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_443280 Show fit | 1.98 |
ENST00000508022.1
|
exocyst complex component 3 |
|
| chr12_+_100594557 Show fit | 1.69 |
ENST00000546902.1
ENST00000552376.1 ENST00000551617.1 |
ARP6 actin-related protein 6 homolog (yeast) |
|
| chr2_+_38152462 Show fit | 1.65 |
ENST00000354545.2
|
regulator of microtubule dynamics 2 |
|
| chr2_+_198318217 Show fit | 1.60 |
ENST00000409398.1
|
coenzyme Q10 homolog B (S. cerevisiae) |
|
| chr1_-_153066998 Show fit | 1.52 |
ENST00000368750.3
|
small proline-rich protein 2E |
|
| chr5_+_110074685 Show fit | 1.45 |
ENST00000355943.3
ENST00000447245.2 |
solute carrier family 25, member 46 |
|
| chr5_-_82373260 Show fit | 1.44 |
ENST00000502346.1
|
transmembrane protein 167A |
|
| chr10_-_18948208 Show fit | 1.43 |
ENST00000607346.1
|
ARL5B antisense RNA 1 |
|
| chr12_+_72058130 Show fit | 1.42 |
ENST00000547843.1
|
THAP domain containing, apoptosis associated protein 2 |
|
| chr5_+_158690089 Show fit | 1.33 |
ENST00000296786.6
|
ubiquitin-like domain containing CTD phosphatase 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ELF2_GABPA_ELF5
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 4.6 | GO:0044565 | dendritic cell proliferation(GO:0044565) |
| 0.1 | 3.8 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.2 | 2.9 | GO:0051601 | exocyst localization(GO:0051601) |
| 0.2 | 2.9 | GO:0071285 | cellular response to lithium ion(GO:0071285) |
| 0.7 | 2.7 | GO:0042231 | interleukin-13 biosynthetic process(GO:0042231) |
| 0.0 | 2.6 | GO:0002223 | innate immune response activating cell surface receptor signaling pathway(GO:0002220) stimulatory C-type lectin receptor signaling pathway(GO:0002223) |
| 0.3 | 2.4 | GO:2000286 | receptor internalization involved in canonical Wnt signaling pathway(GO:2000286) |
| 0.1 | 2.4 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
| 0.1 | 2.2 | GO:0071044 | histone mRNA catabolic process(GO:0071044) |
| 0.2 | 2.1 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.0 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.1 | 3.7 | GO:0000145 | exocyst(GO:0000145) |
| 0.1 | 3.7 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 3.2 | GO:0030119 | AP-type membrane coat adaptor complex(GO:0030119) |
| 0.0 | 3.2 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.5 | 2.8 | GO:0005958 | DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) |
| 0.1 | 2.7 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.0 | 2.2 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 2.0 | GO:0000922 | spindle pole(GO:0000922) |
| 0.1 | 1.9 | GO:0030127 | COPII vesicle coat(GO:0030127) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.2 | GO:0000149 | SNARE binding(GO:0000149) |
| 0.0 | 3.5 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 3.5 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.1 | 3.2 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.1 | 2.8 | GO:0016896 | 3'-5'-exoribonuclease activity(GO:0000175) exoribonuclease activity, producing 5'-phosphomonoesters(GO:0016896) |
| 0.0 | 2.6 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 2.5 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.2 | 2.2 | GO:0015450 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450) |
| 0.1 | 2.1 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.2 | 2.0 | GO:0035174 | histone serine kinase activity(GO:0035174) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.2 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.1 | 3.7 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.1 | 3.0 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.0 | 3.0 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 2.5 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.1 | 2.3 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.0 | 2.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 1.8 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.0 | 1.8 | PID P73PATHWAY | p73 transcription factor network |
| 0.0 | 1.8 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.6 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 3.9 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.1 | 3.8 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.0 | 3.3 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 2.8 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.0 | 2.8 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.1 | 2.7 | REACTOME RNA POL I TRANSCRIPTION INITIATION | Genes involved in RNA Polymerase I Transcription Initiation |
| 0.0 | 2.5 | REACTOME SIGNALING BY ILS | Genes involved in Signaling by Interleukins |
| 0.1 | 2.3 | REACTOME INTEGRATION OF PROVIRUS | Genes involved in Integration of provirus |
| 0.1 | 2.3 | REACTOME DOUBLE STRAND BREAK REPAIR | Genes involved in Double-Strand Break Repair |