ISMARA results: EGR3

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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for EGR3_EGR2

Z-value: 0.38

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Transcription factors associated with EGR3_EGR2

Gene Symbol	Gene ID	Gene Info
EGR3 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000179388.8	early growth response 3
EGR2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000122877.9	early growth response 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
EGR2	hg19_v2_chr10_-_64576105_64576133	-0.96	2.1e-03	Click!
EGR3	hg19_v2_chr8_-_22549856_22549927	0.38	4.6e-01	Click!

Activity profile of EGR3_EGR2 motif

Sorted Z-values of EGR3_EGR2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_-_49622348 Show fit	0.52	ENST00000408991.2	C19orf73 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromosome 19 open reading frame 73
chr15_-_80263506 Show fit	0.38	ENST00000335661.6	BCL2A1 Ensembl NCBI GeneCards UniProt NextProt Show fit	BCL2-related protein A1
chr5_-_176924562 Show fit	0.38	ENST00000359895.2 ENST00000355572.2 ENST00000355841.2 ENST00000393551.1 ENST00000505074.1 ENST00000356618.4 ENST00000393546.4	PDLIM7 Ensembl NCBI GeneCards UniProt NextProt Show fit	PDZ and LIM domain 7 (enigma)
chr19_+_49617581 Show fit	0.33	ENST00000391864.3	LIN7B Ensembl NCBI GeneCards UniProt NextProt Show fit	lin-7 homolog B (C. elegans)
chr6_+_31543334 Show fit	0.28	ENST00000449264.2	TNF Ensembl NCBI GeneCards UniProt NextProt Show fit	tumor necrosis factor
chr6_+_43739697 Show fit	0.24	ENST00000230480.6	VEGFA Ensembl NCBI GeneCards UniProt NextProt Show fit	vascular endothelial growth factor A
chr14_-_69445793 Show fit	0.24	ENST00000538545.2 ENST00000394419.4	ACTN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	actinin, alpha 1
chr14_-_69445968 Show fit	0.23	ENST00000438964.2	ACTN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	actinin, alpha 1
chr6_+_138188551 Show fit	0.23	ENST00000237289.4 ENST00000433680.1	TNFAIP3 Ensembl NCBI GeneCards UniProt NextProt Show fit	tumor necrosis factor, alpha-induced protein 3
chr1_+_43148059 Show fit	0.22	ENST00000321358.7 ENST00000332220.6	YBX1 Ensembl NCBI GeneCards UniProt NextProt Show fit	Y box binding protein 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of EGR3_EGR2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0034148	regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) negative regulation of osteoclast proliferation(GO:0090291) negative regulation of CD40 signaling pathway(GO:2000349)
0.0	0.6	GO:0051639	actin filament network formation(GO:0051639)
0.1	0.4	GO:2000657	regulation of apolipoprotein binding(GO:2000656) negative regulation of apolipoprotein binding(GO:2000657)
0.1	0.4	GO:0046985	negative regulation of megakaryocyte differentiation(GO:0045653) positive regulation of hemoglobin biosynthetic process(GO:0046985)
0.0	0.4	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.4	GO:0008053	mitochondrial fusion(GO:0008053)
0.1	0.3	GO:0002874	regulation of chronic inflammatory response to antigenic stimulus(GO:0002874) positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925) positive regulation of translational initiation by iron(GO:0045994)
0.1	0.3	GO:1901675	negative regulation of histone H3-K27 acetylation(GO:1901675)
0.0	0.3	GO:1903361	protein localization to basolateral plasma membrane(GO:1903361)
0.0	0.3	GO:0021842	directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129)

Showing 1 to 10 of 88 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.6	GO:0005916	fascia adherens(GO:0005916)
0.0	0.4	GO:0071204	histone pre-mRNA 3'end processing complex(GO:0071204)
0.0	0.4	GO:0034709	methylosome(GO:0034709)
0.0	0.4	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.4	GO:0031143	pseudopodium(GO:0031143)
0.0	0.3	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
0.0	0.3	GO:0005641	nuclear envelope lumen(GO:0005641)
0.1	0.2	GO:0036117	hyaluranon cable(GO:0036117)
0.0	0.2	GO:0032311	angiogenin-PRI complex(GO:0032311)
0.0	0.2	GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)

Showing 1 to 10 of 25 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.9	GO:0061578	Lys63-specific deubiquitinase activity(GO:0061578)
0.0	0.5	GO:0017166	vinculin binding(GO:0017166)
0.0	0.5	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.0	0.4	GO:0044020	histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0	0.4	GO:0051400	BH domain binding(GO:0051400)
0.0	0.4	GO:0032794	GTPase activating protein binding(GO:0032794)
0.0	0.3	GO:0097016	L27 domain binding(GO:0097016)
0.0	0.3	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	0.3	GO:0017049	GTP-Rho binding(GO:0017049)
0.1	0.2	GO:0045131	pre-mRNA branch point binding(GO:0045131)

Showing 1 to 10 of 48 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
0.8	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.7	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.2	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.1	PID IFNG PATHWAY	IFN-gamma pathway

Showing 1 to 4 of 4 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
0.9	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.6	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.4	REACTOME RAF MAP KINASE CASCADE	Genes involved in RAF/MAP kinase cascade
0.3	REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	Genes involved in SHC1 events in ERBB4 signaling
0.2	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.1	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.1	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.1	REACTOME SHC RELATED EVENTS	Genes involved in SHC-related events

Showing 1 to 8 of 8 entries

Results for EGR3_EGR2

Z-value: 0.38

Motif logo

Transcription factors associated with EGR3_EGR2

Activity-expression correlation:

Activity profile of EGR3_EGR2 motif

Sorted Z-values of EGR3_EGR2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of EGR3_EGR2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: