ISMARA results: EBF1

Project

NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

Navigation

Downloads

Results for EBF1

Z-value: 1.48

Motif logo

Transcription factors associated with EBF1

Gene Symbol	Gene ID	Gene Info
EBF1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000164330.12	EBF transcription factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
EBF1	hg19_v2_chr5_-_158526756_158526797	-0.86	3.0e-02	Click!

Activity profile of EBF1 motif

Sorted Z-values of EBF1 motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_-_27998689 Show fit	1.37	ENST00000339145.4 ENST00000362020.4 ENST00000361157.6	IFI6 Ensembl NCBI GeneCards UniProt NextProt Show fit	interferon, alpha-inducible protein 6
chr14_+_103592636 Show fit	1.28	ENST00000333007.1	TNFAIP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	tumor necrosis factor, alpha-induced protein 2
chr12_-_49259643 Show fit	1.28	ENST00000309739.5	RND1 Ensembl NCBI GeneCards UniProt NextProt Show fit	Rho family GTPase 1
chr2_-_241835561 Show fit	1.00	ENST00000388934.4	C2orf54 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromosome 2 open reading frame 54
chr19_-_50990785 Show fit	0.95	ENST00000595005.1	CTD-2545M3.8 Ensembl NCBI GeneCards UniProt NextProt Show fit	CTD-2545M3.8
chr1_-_47655686 Show fit	0.93	ENST00000294338.2	PDZK1IP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	PDZK1 interacting protein 1
chr6_+_31895467 Show fit	0.92	ENST00000556679.1 ENST00000456570.1	CFB Ensembl NCBI GeneCards UniProt NextProt Show fit CFB Ensembl NCBI GeneCards UniProt NextProt Show fit	complement factor B Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B
chr6_-_31550192 Show fit	0.90	ENST00000429299.2 ENST00000446745.2	LTB Ensembl NCBI GeneCards UniProt NextProt Show fit	lymphotoxin beta (TNF superfamily, member 3)
chr6_+_31895480 Show fit	0.79	ENST00000418949.2 ENST00000383177.3 ENST00000477310.1	C2 Ensembl NCBI GeneCards UniProt NextProt Show fit CFB Ensembl NCBI GeneCards UniProt NextProt Show fit	complement component 2 Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B
chr15_-_74494779 Show fit	0.78	ENST00000571341.1	STRA6 Ensembl NCBI GeneCards UniProt NextProt Show fit	stimulated by retinoic acid 6

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of EBF1

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.3	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.1	1.7	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.1	1.7	GO:0090023	positive regulation of neutrophil chemotaxis(GO:0090023)
0.0	1.7	GO:0071357	type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.3	1.5	GO:0061143	alveolar primary septum development(GO:0061143)
0.2	1.4	GO:1904274	tricellular tight junction assembly(GO:1904274)
0.1	1.4	GO:0051902	negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.0	1.4	GO:0061726	mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.3	1.3	GO:0018153	isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.2	1.3	GO:0045007	depurination(GO:0045007)

Showing 1 to 10 of 387 entries

Gene overrepresentation in cellular_component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.1	GO:1904724	tertiary granule lumen(GO:1904724)
0.1	1.5	GO:0061689	tricellular tight junction(GO:0061689)
0.0	1.2	GO:0035578	azurophil granule lumen(GO:0035578)
0.0	1.0	GO:0090533	cation-transporting ATPase complex(GO:0090533) ATPase dependent transmembrane transport complex(GO:0098533)
0.2	0.8	GO:0031933	telomeric heterochromatin(GO:0031933)
0.0	0.8	GO:0000177	cytoplasmic exosome (RNase complex)(GO:0000177)
0.0	0.8	GO:0030056	hemidesmosome(GO:0030056)
0.1	0.7	GO:0043260	laminin-11 complex(GO:0043260)
0.0	0.7	GO:0000145	exocyst(GO:0000145)
0.0	0.7	GO:0030057	desmosome(GO:0030057)

Showing 1 to 10 of 135 entries

Gene overrepresentation in molecular_function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.5	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.1	1.9	GO:0001848	complement binding(GO:0001848)
0.1	1.8	GO:0038062	protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0	1.7	GO:0051183	vitamin transporter activity(GO:0051183)
0.3	1.3	GO:0032406	MutLbeta complex binding(GO:0032406) MutSbeta complex binding(GO:0032408)
0.0	1.3	GO:0004622	lysophospholipase activity(GO:0004622)
0.0	1.3	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1	1.2	GO:0005280	hydrogen:amino acid symporter activity(GO:0005280)
0.0	1.2	GO:0001784	phosphotyrosine binding(GO:0001784)
0.1	1.1	GO:0003680	AT DNA binding(GO:0003680)

Showing 1 to 10 of 268 entries

Gene overrepresentation in C2:CP category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.9	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	1.9	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	1.7	PID LYSOPHOSPHOLIPID PATHWAY	LPA receptor mediated events
0.0	1.4	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.0	1.3	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.0	1.3	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.0	1.1	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	1.1	PID LKB1 PATHWAY	LKB1 signaling events
0.0	1.0	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.1	0.9	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway

Showing 1 to 10 of 30 entries

Gene overrepresentation in C2:CP:REACTOME category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.2	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.1	2.2	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.0	2.1	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1	1.3	REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0	1.2	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.0	1.2	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.0	1.0	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.0	1.0	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	1.0	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	0.7	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts

Showing 1 to 10 of 56 entries

Results for EBF1

Z-value: 1.48

Motif logo

Transcription factors associated with EBF1

Activity-expression correlation:

Activity profile of EBF1 motif

Sorted Z-values of EBF1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of EBF1

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: