Project
NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
Navigation
Downloads
Results for E2F7_E2F1
Z-value: 2.03
Motif logo
Transcription factors associated with E2F7_E2F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F7 | hg19_v2_chr12_-_77459306_77459365 | 0.93 | 7.9e-03 | Click! |
| E2F1 | hg19_v2_chr20_-_32274179_32274213 | -0.27 | 6.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F7_E2F1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 4.7 | GO:1903461 | Okazaki fragment processing involved in mitotic DNA replication(GO:1903461) |
| 0.2 | 4.7 | GO:0051383 | kinetochore organization(GO:0051383) |
| 0.1 | 2.4 | GO:0046827 | positive regulation of protein export from nucleus(GO:0046827) |
| 0.0 | 2.2 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.0 | 2.2 | GO:0090307 | mitotic spindle assembly(GO:0090307) |
| 0.2 | 1.9 | GO:1900264 | regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264) |
| 0.1 | 1.8 | GO:2001032 | regulation of double-strand break repair via nonhomologous end joining(GO:2001032) |
| 0.1 | 1.8 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 0.1 | 1.6 | GO:0006465 | signal peptide processing(GO:0006465) |
| 0.1 | 1.5 | GO:0010457 | centriole-centriole cohesion(GO:0010457) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.7 | GO:0000796 | condensin complex(GO:0000796) |
| 0.3 | 2.6 | GO:0005663 | DNA replication factor C complex(GO:0005663) |
| 0.1 | 2.4 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.2 | 1.9 | GO:0001739 | sex chromatin(GO:0001739) |
| 0.0 | 1.9 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.0 | 1.8 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.0 | 1.8 | GO:0005814 | centriole(GO:0005814) |
| 0.2 | 1.7 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 0.2 | 1.6 | GO:0070695 | FHF complex(GO:0070695) |
| 0.0 | 1.6 | GO:0005876 | spindle microtubule(GO:0005876) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.4 | GO:0003910 | DNA ligase (ATP) activity(GO:0003910) |
| 0.0 | 3.0 | GO:0042393 | histone binding(GO:0042393) |
| 0.2 | 2.3 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
| 0.0 | 2.2 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.2 | 2.0 | GO:0043515 | kinetochore binding(GO:0043515) |
| 0.0 | 2.0 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.1 | 1.9 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.0 | 1.8 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.0 | 1.7 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.0 | 1.6 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.3 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 3.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 2.9 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 1.7 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 1.2 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 1.2 | PID FAS PATHWAY | FAS (CD95) signaling pathway |
| 0.1 | 1.1 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
| 0.0 | 0.8 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.8 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.1 | 0.6 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 7.6 | REACTOME LAGGING STRAND SYNTHESIS | Genes involved in Lagging Strand Synthesis |
| 0.0 | 6.6 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 1.7 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.1 | 1.7 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.0 | 1.6 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 0.0 | 1.5 | REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.1 | 1.3 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.0 | 1.3 | REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.0 | 1.0 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.0 | 0.9 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |