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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for E2F6
Z-value: 1.70
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Transcription factors associated with E2F6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F6 | hg19_v2_chr2_-_11605966_11606005 | 0.26 | 6.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_+_96928516 Show fit | 1.34 |
ENST00000602703.1
|
RP11-2B6.3 |
|
| chr19_-_48673465 Show fit | 1.34 |
ENST00000598938.1
|
ligase I, DNA, ATP-dependent |
|
| chr12_-_58145889 Show fit | 1.20 |
ENST00000547853.1
|
cyclin-dependent kinase 4 |
|
| chr17_-_58469591 Show fit | 0.89 |
ENST00000589335.1
|
ubiquitin specific peptidase 32 |
|
| chr2_-_174828892 Show fit | 0.89 |
ENST00000418194.2
|
Sp3 transcription factor |
|
| chr10_-_126849626 Show fit | 0.85 |
ENST00000530884.1
|
C-terminal binding protein 2 |
|
| chr1_+_51434357 Show fit | 0.84 |
ENST00000396148.1
|
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) |
|
| chr20_+_31350184 Show fit | 0.67 |
ENST00000328111.2
ENST00000353855.2 ENST00000348286.2 |
DNA (cytosine-5-)-methyltransferase 3 beta |
|
| chr17_-_58469329 Show fit | 0.66 |
ENST00000393003.3
|
ubiquitin specific peptidase 32 |
|
| chr14_-_81902791 Show fit | 0.64 |
ENST00000557055.1
|
stonin 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F6
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | GO:0051225 | spindle assembly(GO:0051225) |
| 0.1 | 1.2 | GO:2000675 | negative regulation of type B pancreatic cell apoptotic process(GO:2000675) |
| 0.0 | 1.2 | GO:0043044 | ATP-dependent chromatin remodeling(GO:0043044) |
| 0.1 | 1.1 | GO:0060136 | embryonic process involved in female pregnancy(GO:0060136) |
| 0.1 | 1.1 | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition(GO:0060244) |
| 0.0 | 1.1 | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) |
| 0.1 | 1.0 | GO:0018242 | protein O-linked glycosylation via serine(GO:0018242) |
| 0.1 | 1.0 | GO:0010724 | regulation of definitive erythrocyte differentiation(GO:0010724) |
| 0.1 | 1.0 | GO:0043402 | glucocorticoid mediated signaling pathway(GO:0043402) |
| 0.1 | 1.0 | GO:0075713 | establishment of integrated proviral latency(GO:0075713) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.2 | 1.7 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.0 | 1.7 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 1.7 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.0 | 1.5 | GO:0090544 | BAF-type complex(GO:0090544) |
| 0.0 | 1.2 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.1 | 1.1 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 1.0 | GO:0005849 | mRNA cleavage factor complex(GO:0005849) |
| 0.0 | 1.0 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.1 | 0.9 | GO:0097470 | ribbon synapse(GO:0097470) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.1 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 2.3 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 2.1 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.1 | 1.5 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.1 | 1.4 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.1 | 1.2 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
| 0.1 | 1.2 | GO:0097100 | supercoiled DNA binding(GO:0097100) |
| 0.1 | 1.0 | GO:0070137 | ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139) |
| 0.0 | 1.0 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.2 | 0.9 | GO:0047860 | diiodophenylpyruvate reductase activity(GO:0047860) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.9 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 2.3 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 1.8 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 1.4 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 1.3 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 1.2 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 1.1 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 1.1 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 0.9 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.9 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.0 | 1.7 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 1.6 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 1.3 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.0 | 1.2 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 1.2 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 1.1 | REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS | Genes involved in Activation of ATR in response to replication stress |
| 0.1 | 1.0 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.1 | 1.0 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 0.0 | 1.0 | REACTOME MYOGENESIS | Genes involved in Myogenesis |