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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for E2F4

Z-value: 0.66

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Transcription factors associated with E2F4

Gene Symbol Gene ID Gene Info
E2F4
ENSG00000205250.4 E2F4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2F4hg19_v2_chr16_+_67226019_67226127-0.562.5e-01Click!

Activity profile of E2F4 motif

Sorted Z-values of E2F4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F4

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr19_-_48673465 0.75 ENST00000598938.1
 LIG1
 ligase I, DNA, ATP-dependent
chr4_-_185655212 0.38 ENST00000541971.1
 MLF1IP
 centromere protein U
chr1_+_60280458 0.37 ENST00000455990.1
ENST00000371208.3
 HOOK1
 hook microtubule-tethering protein 1
chr11_-_82612549 0.34 ENST00000528082.1
ENST00000533126.1
 PRCP
 prolylcarboxypeptidase (angiotensinase C)
chr4_+_166128836 0.34 ENST00000511305.1
 KLHL2
 kelch-like family member 2
chr2_+_172778952 0.33 ENST00000392584.1
ENST00000264108.4
 HAT1
 histone acetyltransferase 1
chr19_-_42894420 0.32 ENST00000597255.1
ENST00000222032.5
 CNFN
 cornifelin
chr14_-_55658323 0.31 ENST00000554067.1
ENST00000247191.2
 DLGAP5
 discs, large (Drosophila) homolog-associated protein 5
chr1_-_935491 0.30 ENST00000304952.6
 HES4
 hes family bHLH transcription factor 4
chr17_+_34890807 0.29 ENST00000429467.2
ENST00000592983.1
 PIGW
 phosphatidylinositol glycan anchor biosynthesis, class W
chr4_+_178230985 0.29 ENST00000264596.3
 NEIL3
 nei endonuclease VIII-like 3 (E. coli)
chr8_+_27491381 0.29 ENST00000337221.4
 SCARA3
 scavenger receptor class A, member 3
chr9_-_113018746 0.27 ENST00000374515.5
 TXN
 thioredoxin
chr14_-_50154921 0.27 ENST00000553805.2
ENST00000554396.1
ENST00000216367.5
ENST00000539565.2
 POLE2
 polymerase (DNA directed), epsilon 2, accessory subunit
chr4_-_185655278 0.27 ENST00000281453.5
 MLF1IP
 centromere protein U
chr1_-_197115818 0.26 ENST00000367409.4
ENST00000294732.7
 ASPM
 asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr8_+_42911552 0.26 ENST00000525699.1
ENST00000529687.1
 FNTA
 farnesyltransferase, CAAX box, alpha
chr3_+_5163905 0.25 ENST00000256496.3
ENST00000419534.2
 ARL8B
 ADP-ribosylation factor-like 8B
chr6_+_27114861 0.25 ENST00000377459.1
 HIST1H2AH
 histone cluster 1, H2ah
chr10_-_70231639 0.25 ENST00000551118.2
ENST00000358410.3
ENST00000399180.2
ENST00000399179.2
 DNA2
 DNA replication helicase/nuclease 2
chr10_-_70166946 0.24 ENST00000388768.2
 RUFY2
 RUN and FYVE domain containing 2
chr1_+_63833261 0.24 ENST00000371108.4
 ALG6
 ALG6, alpha-1,3-glucosyltransferase
chr1_-_935519 0.23 ENST00000428771.2
 HES4
 hes family bHLH transcription factor 4
chr7_-_77427676 0.23 ENST00000257663.3
 TMEM60
 transmembrane protein 60
chr7_-_152373216 0.23 ENST00000359321.1
 XRCC2
 X-ray repair complementing defective repair in Chinese hamster cells 2
chr6_-_17706618 0.23 ENST00000262077.2
ENST00000537253.1
 NUP153
 nucleoporin 153kDa
chr10_-_70166999 0.23 ENST00000454950.2
ENST00000342616.4
ENST00000602465.1
ENST00000399200.2
 RUFY2
 RUN and FYVE domain containing 2
chr16_+_67193834 0.23 ENST00000258200.3
ENST00000518148.1
ENST00000519917.1
ENST00000517382.1
ENST00000521920.1
 FBXL8
 F-box and leucine-rich repeat protein 8
chr7_-_32931623 0.22 ENST00000452926.1
 KBTBD2
 kelch repeat and BTB (POZ) domain containing 2
chr19_+_7953417 0.22 ENST00000600345.1
ENST00000598224.1
 LRRC8E
 leucine rich repeat containing 8 family, member E
chr6_-_20212630 0.22 ENST00000324607.7
ENST00000541730.1
ENST00000536798.1
 MBOAT1
 membrane bound O-acyltransferase domain containing 1
chr5_+_14664762 0.21 ENST00000284274.4
 FAM105B
 family with sequence similarity 105, member B
chr15_+_48624300 0.21 ENST00000455976.2
ENST00000559540.1
 DUT
 deoxyuridine triphosphatase
chr6_-_139695757 0.21 ENST00000367651.2
 CITED2
 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr6_+_89790459 0.20 ENST00000369472.1
 PNRC1
 proline-rich nuclear receptor coactivator 1
chr7_+_130794878 0.20 ENST00000416992.2
 MKLN1
 muskelin 1, intracellular mediator containing kelch motifs
chr15_+_91260552 0.20 ENST00000355112.3
ENST00000560509.1
 BLM
 Bloom syndrome, RecQ helicase-like
chr11_+_31531291 0.20 ENST00000350638.5
ENST00000379163.5
ENST00000395934.2
 ELP4
 elongator acetyltransferase complex subunit 4
chr1_+_173837488 0.19 ENST00000427304.1
ENST00000432989.1
ENST00000367702.1
 ZBTB37
 zinc finger and BTB domain containing 37
chr11_-_64570624 0.19 ENST00000439069.1
 MAP4K2
 mitogen-activated protein kinase kinase kinase kinase 2
chr1_+_104068562 0.19 ENST00000423855.2
 RNPC3
 RNA-binding region (RNP1, RRM) containing 3
chr20_+_47662805 0.19 ENST00000262982.2
ENST00000542325.1
 CSE1L
 CSE1 chromosome segregation 1-like (yeast)
chr2_-_17935059 0.18 ENST00000448223.2
ENST00000381272.4
ENST00000351948.4
 SMC6
 structural maintenance of chromosomes 6
chr2_+_71357434 0.18 ENST00000244230.2
 MPHOSPH10
 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
chr12_+_102514019 0.18 ENST00000537257.1
ENST00000358383.5
ENST00000392911.2
 PARPBP
 PARP1 binding protein
chr1_+_91966384 0.18 ENST00000430031.2
ENST00000234626.6
 CDC7
 cell division cycle 7
chr11_+_58910201 0.18 ENST00000528737.1
 FAM111A
 family with sequence similarity 111, member A
chr3_+_37903432 0.17 ENST00000443503.2
 CTDSPL
 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chrX_+_100353153 0.17 ENST00000423383.1
ENST00000218507.5
ENST00000403304.2
ENST00000435570.1
 CENPI
 centromere protein I
chr3_+_180630444 0.17 ENST00000491062.1
ENST00000468861.1
ENST00000445140.2
ENST00000484958.1
 FXR1
 fragile X mental retardation, autosomal homolog 1
chr19_+_48673949 0.17 ENST00000328759.7
 C19orf68
 chromosome 19 open reading frame 68
chr18_-_54318353 0.17 ENST00000590954.1
ENST00000540155.1
 TXNL1
 thioredoxin-like 1
chr11_-_61596753 0.17 ENST00000448607.1
ENST00000421879.1
 FADS1
 fatty acid desaturase 1
chr14_-_93673353 0.17 ENST00000556566.1
ENST00000306954.4
 C14orf142
 chromosome 14 open reading frame 142
chr10_+_82116529 0.17 ENST00000411538.1
ENST00000256039.2
 DYDC2
 DPY30 domain containing 2
chr7_-_30544405 0.16 ENST00000409390.1
ENST00000409144.1
ENST00000005374.6
ENST00000409436.1
ENST00000275428.4
 GGCT
 gamma-glutamylcyclotransferase
chr4_-_157892055 0.16 ENST00000422544.2
 PDGFC
 platelet derived growth factor C
chr1_-_243417762 0.16 ENST00000522191.1
 CEP170
 centrosomal protein 170kDa
chr1_+_104068312 0.16 ENST00000524631.1
ENST00000531883.1
ENST00000533099.1
ENST00000527062.1
 RNPC3
 RNA-binding region (RNP1, RRM) containing 3
chr6_-_71666732 0.16 ENST00000230053.6
 B3GAT2
 beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)
chr2_+_71357744 0.16 ENST00000498451.2
 MPHOSPH10
 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
chr1_+_6845578 0.16 ENST00000467404.2
ENST00000439411.2
 CAMTA1
 calmodulin binding transcription activator 1
chr2_+_17935119 0.16 ENST00000317402.7
 GEN1
 GEN1 Holliday junction 5' flap endonuclease
chr4_-_120549163 0.16 ENST00000394439.1
ENST00000420633.1
 PDE5A
 phosphodiesterase 5A, cGMP-specific
chr1_+_6845497 0.16 ENST00000473578.1
ENST00000557126.1
 CAMTA1
 calmodulin binding transcription activator 1
chr13_+_34392200 0.16 ENST00000434425.1
 RFC3
 replication factor C (activator 1) 3, 38kDa
chr3_+_160117418 0.16 ENST00000465903.1
ENST00000485645.1
ENST00000360111.2
ENST00000472991.1
ENST00000467468.1
ENST00000469762.1
ENST00000489573.1
ENST00000462787.1
ENST00000490207.1
ENST00000485867.1
 SMC4
 structural maintenance of chromosomes 4
chr11_-_82612678 0.16 ENST00000534631.1
ENST00000531801.1
 PRCP
 prolylcarboxypeptidase (angiotensinase C)
chr5_-_36242119 0.16 ENST00000511088.1
ENST00000282512.3
ENST00000506945.1
 NADK2
 NAD kinase 2, mitochondrial
chr17_-_15902951 0.16 ENST00000472495.1
 ZSWIM7
 zinc finger, SWIM-type containing 7
chr5_+_141348755 0.16 ENST00000506004.1
ENST00000507291.1
 RNF14
 ring finger protein 14
chr9_+_17135016 0.16 ENST00000425824.1
ENST00000262360.5
ENST00000380641.4
 CNTLN
 centlein, centrosomal protein
chr14_-_64010006 0.15 ENST00000555899.1
 PPP2R5E
 protein phosphatase 2, regulatory subunit B', epsilon isoform
chr4_-_1713977 0.15 ENST00000318386.4
 SLBP
 stem-loop binding protein
chr15_+_93426514 0.15 ENST00000556722.1
 CHD2
 chromodomain helicase DNA binding protein 2
chr4_+_88928777 0.15 ENST00000237596.2
 PKD2
 polycystic kidney disease 2 (autosomal dominant)
chr2_+_29033682 0.15 ENST00000379579.4
ENST00000334056.5
ENST00000449210.1
 SPDYA
 speedy/RINGO cell cycle regulator family member A
chr1_+_185014647 0.14 ENST00000367509.4
 RNF2
 ring finger protein 2
chr11_-_31531121 0.14 ENST00000532287.1
ENST00000526776.1
ENST00000534812.1
ENST00000529749.1
ENST00000278200.1
ENST00000530023.1
ENST00000533642.1
 IMMP1L
 IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chrX_-_47863348 0.14 ENST00000376943.3
ENST00000396965.1
ENST00000305127.6
 ZNF182
 zinc finger protein 182
chr4_-_1714037 0.14 ENST00000488267.1
ENST00000429429.2
ENST00000480936.1
 SLBP
 stem-loop binding protein
chr2_-_110371720 0.14 ENST00000356688.4
 SEPT10
 septin 10
chr2_-_17935027 0.14 ENST00000446852.1
 SMC6
 structural maintenance of chromosomes 6
chr10_-_62493223 0.14 ENST00000373827.2
 ANK3
 ankyrin 3, node of Ranvier (ankyrin G)
chr16_+_11439286 0.14 ENST00000312499.5
ENST00000576027.1
 RMI2
 RecQ mediated genome instability 2
chr9_-_115480303 0.14 ENST00000374234.1
ENST00000374238.1
ENST00000374236.1
ENST00000374242.4
 INIP
 INTS3 and NABP interacting protein
chr6_+_45389893 0.14 ENST00000371432.3
 RUNX2
 runt-related transcription factor 2
chr8_+_95731904 0.14 ENST00000522422.1
 DPY19L4
 dpy-19-like 4 (C. elegans)
chr4_+_166128735 0.14 ENST00000226725.6
 KLHL2
 kelch-like family member 2
chr8_+_95732095 0.14 ENST00000414645.2
 DPY19L4
 dpy-19-like 4 (C. elegans)
chr4_+_331578 0.14 ENST00000512994.1
 ZNF141
 zinc finger protein 141
chr16_-_30064244 0.14 ENST00000571269.1
ENST00000561666.1
 FAM57B
 family with sequence similarity 57, member B
chrX_-_20159934 0.14 ENST00000379593.1
ENST00000379607.5
 EIF1AX
 eukaryotic translation initiation factor 1A, X-linked
chr5_-_36152031 0.14 ENST00000296603.4
 LMBRD2
 LMBR1 domain containing 2
chr2_-_46844159 0.14 ENST00000474980.1
ENST00000306465.4
 PIGF
 phosphatidylinositol glycan anchor biosynthesis, class F
chr5_+_141348640 0.13 ENST00000540015.1
ENST00000506938.1
ENST00000394514.2
ENST00000512565.1
ENST00000394515.3
 RNF14
 ring finger protein 14
chr14_-_54420133 0.13 ENST00000559501.1
ENST00000558984.1
 BMP4
 bone morphogenetic protein 4
chr5_-_137548997 0.13 ENST00000505120.1
ENST00000394886.2
ENST00000394884.3
 CDC23
 cell division cycle 23
chr9_-_113018835 0.13 ENST00000374517.5
 TXN
 thioredoxin
chr2_+_17935383 0.13 ENST00000524465.1
ENST00000381254.2
ENST00000532257.1
 GEN1
 GEN1 Holliday junction 5' flap endonuclease
chr7_+_77428066 0.13 ENST00000422959.2
ENST00000307305.8
ENST00000424760.1
 PHTF2
 putative homeodomain transcription factor 2
chr4_-_39460496 0.13 ENST00000449470.2
 RPL9
 ribosomal protein L9
chr13_+_34392185 0.13 ENST00000380071.3
 RFC3
 replication factor C (activator 1) 3, 38kDa
chr22_-_42343117 0.13 ENST00000407253.3
ENST00000215980.5
 CENPM
 centromere protein M
chr7_-_86849883 0.13 ENST00000433078.1
 TMEM243
 transmembrane protein 243, mitochondrial
chr10_+_122216316 0.13 ENST00000398250.1
ENST00000439221.1
ENST00000398248.1
 PPAPDC1A
 phosphatidic acid phosphatase type 2 domain containing 1A
chr11_+_58910295 0.13 ENST00000420244.1
 FAM111A
 family with sequence similarity 111, member A
chrX_+_133594168 0.13 ENST00000298556.7
 HPRT1
 hypoxanthine phosphoribosyltransferase 1
chr17_+_5390220 0.13 ENST00000381165.3
 MIS12
 MIS12 kinetochore complex component
chr12_+_102513950 0.13 ENST00000378128.3
ENST00000327680.2
ENST00000541394.1
ENST00000543784.1
 PARPBP
 PARP1 binding protein
chr9_+_17134980 0.13 ENST00000380647.3
 CNTLN
 centlein, centrosomal protein
chr4_+_331619 0.13 ENST00000505939.1
ENST00000240499.7
 ZNF141
 zinc finger protein 141
chr4_+_39460659 0.12 ENST00000513731.1
 LIAS
 lipoic acid synthetase
chr17_-_30185946 0.12 ENST00000579741.1
 COPRS
 coordinator of PRMT5, differentiation stimulator
chr13_+_32889605 0.12 ENST00000380152.3
ENST00000544455.1
ENST00000530893.2
 BRCA2
 breast cancer 2, early onset
chr2_-_61765732 0.12 ENST00000443240.1
ENST00000436018.1
 XPO1
 exportin 1 (CRM1 homolog, yeast)
chr7_+_116165754 0.12 ENST00000405348.1
 CAV1
 caveolin 1, caveolae protein, 22kDa
chr1_-_28241024 0.12 ENST00000313433.7
ENST00000444045.1
 RPA2
 replication protein A2, 32kDa
chr15_+_71184931 0.12 ENST00000560369.1
ENST00000260382.5
 LRRC49
 leucine rich repeat containing 49
chr1_-_935361 0.12 ENST00000484667.2
 HES4
 hes family bHLH transcription factor 4
chr4_-_120548779 0.12 ENST00000264805.5
 PDE5A
 phosphodiesterase 5A, cGMP-specific
chr22_-_42342733 0.12 ENST00000402420.1
 CENPM
 centromere protein M
chr2_-_110371777 0.12 ENST00000397712.2
 SEPT10
 septin 10
chr1_+_179262905 0.12 ENST00000539888.1
ENST00000540564.1
ENST00000535686.1
ENST00000367619.3
 SOAT1
 sterol O-acyltransferase 1
chr3_-_113415441 0.12 ENST00000491165.1
ENST00000316407.4
 KIAA2018
 KIAA2018
chr5_+_141348721 0.12 ENST00000507163.1
ENST00000394519.1
 RNF14
 ring finger protein 14
chr15_+_42841008 0.12 ENST00000260372.3
ENST00000568876.1
ENST00000568846.2
ENST00000562398.1
 HAUS2
 HAUS augmin-like complex, subunit 2
chr22_+_46972975 0.12 ENST00000431155.1
 GRAMD4
 GRAM domain containing 4
chr11_+_82612740 0.11 ENST00000524921.1
ENST00000528759.1
ENST00000525361.1
ENST00000430323.2
ENST00000533655.1
ENST00000532764.1
ENST00000532589.1
ENST00000525388.1
 C11orf82
 chromosome 11 open reading frame 82
chr2_+_230787213 0.11 ENST00000409992.1
 FBXO36
 F-box protein 36
chr6_+_71123107 0.11 ENST00000370479.3
ENST00000505769.1
ENST00000515323.1
ENST00000515280.1
ENST00000507085.1
ENST00000457062.2
ENST00000361499.3
 FAM135A
 family with sequence similarity 135, member A
chr1_-_236030216 0.11 ENST00000389794.3
ENST00000389793.2
 LYST
 lysosomal trafficking regulator
chr2_-_110371412 0.11 ENST00000415095.1
ENST00000334001.6
ENST00000437928.1
ENST00000493445.1
ENST00000397714.2
ENST00000461295.1
 SEPT10
 septin 10
chr21_-_33651324 0.11 ENST00000290130.3
 MIS18A
 MIS18 kinetochore protein A
chr7_+_77428149 0.11 ENST00000415251.2
ENST00000275575.7
 PHTF2
 putative homeodomain transcription factor 2
chr10_-_88281494 0.11 ENST00000298767.5
 WAPAL
 wings apart-like homolog (Drosophila)
chr4_+_175204818 0.11 ENST00000503780.1
 CEP44
 centrosomal protein 44kDa
chrX_+_14891598 0.11 ENST00000497603.2
 MOSPD2
 motile sperm domain containing 2
chr6_-_110012380 0.11 ENST00000424296.2
ENST00000341338.6
ENST00000368948.2
ENST00000285397.5
 AK9
 adenylate kinase 9
chr3_-_112738565 0.11 ENST00000383675.2
ENST00000314400.5
 C3orf17
 chromosome 3 open reading frame 17
chr17_-_41277467 0.11 ENST00000494123.1
ENST00000346315.3
ENST00000309486.4
ENST00000468300.1
ENST00000354071.3
ENST00000352993.3
ENST00000471181.2
 BRCA1
 breast cancer 1, early onset
chr5_-_79950371 0.11 ENST00000511032.1
ENST00000504396.1
ENST00000505337.1
 DHFR
 dihydrofolate reductase
chr4_-_157892498 0.11 ENST00000502773.1
 PDGFC
 platelet derived growth factor C
chr22_-_42342692 0.10 ENST00000404067.1
ENST00000402338.1
 CENPM
 centromere protein M
chr19_-_53238260 0.10 ENST00000453741.2
ENST00000602162.1
ENST00000601643.1
ENST00000596702.1
ENST00000600943.1
ENST00000543227.1
ENST00000540744.1
 ZNF611
 zinc finger protein 611
chr7_-_102985035 0.10 ENST00000426036.2
ENST00000249270.7
ENST00000454277.1
ENST00000412522.1
 DNAJC2
 DnaJ (Hsp40) homolog, subfamily C, member 2
chr8_-_101322132 0.10 ENST00000523481.1
 RNF19A
 ring finger protein 19A, RBR E3 ubiquitin protein ligase
chr3_-_160117301 0.10 ENST00000326448.7
ENST00000498409.1
ENST00000475677.1
ENST00000478536.1
 IFT80
 intraflagellar transport 80 homolog (Chlamydomonas)
chr17_-_30185971 0.10 ENST00000378634.2
 COPRS
 coordinator of PRMT5, differentiation stimulator
chr6_-_100016678 0.10 ENST00000523799.1
ENST00000520429.1
 CCNC
 cyclin C
chr2_+_47630108 0.10 ENST00000233146.2
ENST00000454849.1
ENST00000543555.1
 MSH2
 mutS homolog 2
chr15_+_36871983 0.10 ENST00000437989.2
ENST00000569302.1
 C15orf41
 chromosome 15 open reading frame 41
chr1_+_93913665 0.10 ENST00000271234.7
ENST00000370256.4
ENST00000260506.8
 FNBP1L
 formin binding protein 1-like
chr8_-_124408652 0.10 ENST00000287394.5
 ATAD2
 ATPase family, AAA domain containing 2
chr7_-_42971759 0.10 ENST00000538645.1
ENST00000445517.1
ENST00000223321.4
 PSMA2
 proteasome (prosome, macropain) subunit, alpha type, 2
chr4_-_1107306 0.10 ENST00000433731.2
ENST00000333673.5
ENST00000382968.5
 RNF212
 ring finger protein 212
chr6_+_89790490 0.10 ENST00000336032.3
 PNRC1
 proline-rich nuclear receptor coactivator 1
chr8_+_48873479 0.10 ENST00000262105.2
 MCM4
 minichromosome maintenance complex component 4
chr11_-_72853267 0.10 ENST00000409418.4
 FCHSD2
 FCH and double SH3 domains 2
chr1_+_184356188 0.10 ENST00000235307.6
 C1orf21
 chromosome 1 open reading frame 21
chr9_+_110046334 0.09 ENST00000416373.2
 RAD23B
 RAD23 homolog B (S. cerevisiae)
chr6_-_100016527 0.09 ENST00000523985.1
ENST00000518714.1
ENST00000520371.1
 CCNC
 cyclin C
chr11_-_123525289 0.09 ENST00000392770.2
ENST00000299333.3
ENST00000530277.1
 SCN3B
 sodium channel, voltage-gated, type III, beta subunit
chr5_+_141348598 0.09 ENST00000394520.2
ENST00000347642.3
 RNF14
 ring finger protein 14
chrX_-_14891150 0.09 ENST00000452869.1
ENST00000398334.1
ENST00000324138.3
 FANCB
 Fanconi anemia, complementation group B
chr6_+_126661253 0.09 ENST00000368326.1
ENST00000368325.1
ENST00000368328.4
 CENPW
 centromere protein W
chr15_+_40987327 0.09 ENST00000423169.2
ENST00000267868.3
ENST00000557850.1
ENST00000532743.1
ENST00000382643.3
 RAD51
 RAD51 recombinase
chr6_-_82957433 0.09 ENST00000306270.7
 IBTK
 inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr3_-_148804275 0.09 ENST00000392912.2
ENST00000465259.1
ENST00000310053.5
ENST00000494055.1
 HLTF
 helicase-like transcription factor
chr9_+_36190853 0.09 ENST00000433436.2
ENST00000538225.1
ENST00000540080.1
 CLTA
 clathrin, light chain A
chr18_-_658244 0.09 ENST00000585033.1
ENST00000323813.3
 C18orf56
 chromosome 18 open reading frame 56
chr3_-_100120223 0.09 ENST00000284320.5
 TOMM70A
 translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
chr11_-_82612727 0.09 ENST00000531128.1
ENST00000535099.1
ENST00000527444.1
 PRCP
 prolylcarboxypeptidase (angiotensinase C)
chr5_+_139027877 0.09 ENST00000302517.3
 CXXC5
 CXXC finger protein 5
chr11_+_34073195 0.09 ENST00000341394.4
 CAPRIN1
 cell cycle associated protein 1
chrX_+_14891522 0.09 ENST00000380492.3
ENST00000482354.1
 MOSPD2
 motile sperm domain containing 2
chr8_+_48873453 0.09 ENST00000523944.1
 MCM4
 minichromosome maintenance complex component 4
chr4_+_154265784 0.09 ENST00000240488.3
 MND1
 meiotic nuclear divisions 1 homolog (S. cerevisiae)
chr5_-_179636153 0.09 ENST00000361132.4
 RASGEF1C
 RasGEF domain family, member 1C
chr4_+_166794383 0.09 ENST00000061240.2
ENST00000507499.1
 TLL1
 tolloid-like 1
chr18_-_45935663 0.09 ENST00000589194.1
ENST00000591279.1
ENST00000590855.1
ENST00000587107.1
ENST00000588970.1
ENST00000586525.1
ENST00000592387.1
ENST00000590800.1
 ZBTB7C
 zinc finger and BTB domain containing 7C
chr12_+_48499252 0.09 ENST00000549003.1
ENST00000550924.1
 PFKM
 phosphofructokinase, muscle
chr1_+_179263308 0.09 ENST00000426956.1
 SOAT1
 sterol O-acyltransferase 1
chr8_-_17104099 0.09 ENST00000524358.1
 CNOT7
 CCR4-NOT transcription complex, subunit 7
chr7_-_100026280 0.09 ENST00000360951.4
ENST00000398027.2
ENST00000324725.6
ENST00000472716.1
 ZCWPW1
 zinc finger, CW type with PWWP domain 1
chr1_-_8939265 0.09 ENST00000489867.1
 ENO1
 enolase 1, (alpha)
chr1_+_173837214 0.09 ENST00000367704.1
 ZBTB37
 zinc finger and BTB domain containing 37
chr7_-_150780487 0.09 ENST00000482202.1
 TMUB1
 transmembrane and ubiquitin-like domain containing 1
chr1_+_91966656 0.09 ENST00000428239.1
ENST00000426137.1
 CDC7
 cell division cycle 7
chr8_-_67525473 0.09 ENST00000522677.3
 MYBL1
 v-myb avian myeloblastosis viral oncogene homolog-like 1
chr11_+_17298522 0.09 ENST00000529313.1
 NUCB2
 nucleobindin 2
chr12_-_15942503 0.09 ENST00000281172.5
 EPS8
 epidermal growth factor receptor pathway substrate 8
chr11_+_32914579 0.09 ENST00000399302.2
 QSER1
 glutamine and serine rich 1
chr14_-_61190754 0.08 ENST00000216513.4
 SIX4
 SIX homeobox 4
chr12_-_57472522 0.08 ENST00000379391.3
ENST00000300128.4
 TMEM194A
 transmembrane protein 194A
chr6_+_3118926 0.08 ENST00000380379.5
 BPHL
 biphenyl hydrolase-like (serine hydrolase)
chr17_-_17184546 0.08 ENST00000417352.1
 COPS3
 COP9 signalosome subunit 3
chr2_+_46844290 0.08 ENST00000238892.3
 CRIPT
 cysteine-rich PDZ-binding protein
chr11_-_73694346 0.08 ENST00000310473.3
 UCP2
 uncoupling protein 2 (mitochondrial, proton carrier)
chr2_+_179059365 0.08 ENST00000190611.4
 OSBPL6
 oxysterol binding protein-like 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:1903461 Okazaki fragment processing involved in mitotic DNA replication(GO:1903461)
0.1 0.3 GO:0071140 resolution of recombination intermediates(GO:0071139) resolution of mitotic recombination intermediates(GO:0071140)
0.1 0.3 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.1 0.3 GO:0046832 negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832)
0.1 0.6 GO:0002353 regulation of thyroid hormone mediated signaling pathway(GO:0002155) kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353)
0.1 0.2 GO:0046081 dUTP metabolic process(GO:0046080) dUTP catabolic process(GO:0046081)
0.1 0.2 GO:0070512 regulation of histone H4-K20 methylation(GO:0070510) positive regulation of histone H4-K20 methylation(GO:0070512)
0.1 0.2 GO:1990426 homologous recombination-dependent replication fork processing(GO:1990426)
0.1 0.2 GO:1900085 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.1 0.4 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.1 0.3 GO:0006311 meiotic gene conversion(GO:0006311)
0.0 0.1 GO:0031587 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587) kidney smooth muscle tissue development(GO:0072194)
0.0 0.2 GO:0009107 lipoate biosynthetic process(GO:0009107)
0.0 0.3 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.0 0.3 GO:0018343 protein farnesylation(GO:0018343)
0.0 0.1 GO:1901069 guanosine-containing compound catabolic process(GO:1901069)
0.0 0.2 GO:0035802 adrenal cortex development(GO:0035801) adrenal cortex formation(GO:0035802) embryonic heart tube left/right pattern formation(GO:0060971)
0.0 0.4 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.1 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.0 0.4 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.0 0.1 GO:0006174 dADP phosphorylation(GO:0006174) dGDP phosphorylation(GO:0006186) AMP phosphorylation(GO:0006756) CDP phosphorylation(GO:0061508) dAMP phosphorylation(GO:0061565) CMP phosphorylation(GO:0061566) dCMP phosphorylation(GO:0061567) GDP phosphorylation(GO:0061568) UDP phosphorylation(GO:0061569) dCDP phosphorylation(GO:0061570) TDP phosphorylation(GO:0061571)
0.0 0.3 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.0 0.2 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.0 0.2 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.0 0.1 GO:1902725 negative regulation of satellite cell differentiation(GO:1902725)
0.0 0.2 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.0 0.3 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0 0.2 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.0 0.1 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.0 0.1 GO:0072101 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm development(GO:0048389) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) pattern specification involved in mesonephros development(GO:0061227) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in kidney development(GO:0072098) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.0 0.1 GO:0046452 dihydrofolate metabolic process(GO:0046452)
0.0 0.3 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.1 GO:1903347 negative regulation of bicellular tight junction assembly(GO:1903347)
0.0 0.3 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.0 0.2 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.0 0.3 GO:0018103 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0 0.1 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.3 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.1 GO:0093001 glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001)
0.0 0.2 GO:0043570 maintenance of DNA repeat elements(GO:0043570)
0.0 0.2 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.2 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.0 0.8 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 0.7 GO:0032201 telomere maintenance via semi-conservative replication(GO:0032201)
0.0 0.1 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.0 0.2 GO:0010212 response to ionizing radiation(GO:0010212)
0.0 0.5 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.1 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
0.0 0.4 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 0.2 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0 0.1 GO:0016267 O-glycan processing, core 1(GO:0016267)
0.0 0.1 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.1 GO:0031642 negative regulation of myelination(GO:0031642)
0.0 0.1 GO:0060584 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0 0.3 GO:0051383 kinetochore organization(GO:0051383)
0.0 0.2 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.3 GO:0009650 UV protection(GO:0009650)
0.0 0.1 GO:0006114 glycerol biosynthetic process(GO:0006114)
0.0 0.1 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.1 GO:0019236 response to pheromone(GO:0019236)
0.0 0.1 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.0 0.2 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.0 0.0 GO:0007500 mesodermal cell fate determination(GO:0007500)
0.0 0.3 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.0 GO:0006423 cysteinyl-tRNA aminoacylation(GO:0006423)
0.0 0.1 GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.0 0.1 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.0 0.0 GO:0031456 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0005953 CAAX-protein geranylgeranyltransferase complex(GO:0005953)
0.1 0.2 GO:0032302 MutSbeta complex(GO:0032302)
0.1 0.3 GO:0034457 Mpp10 complex(GO:0034457)
0.1 0.2 GO:0031436 BRCA1-BARD1 complex(GO:0031436)
0.0 0.1 GO:0032301 MutSalpha complex(GO:0032301)
0.0 0.1 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.3 GO:0035061 interchromatin granule(GO:0035061)
0.0 0.4 GO:0070695 FHF complex(GO:0070695)
0.0 0.1 GO:0000818 nuclear MIS12/MIND complex(GO:0000818)
0.0 0.2 GO:0097196 Shu complex(GO:0097196)
0.0 0.3 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.1 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.0 0.3 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.3 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 0.2 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.3 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.3 GO:0001739 sex chromatin(GO:0001739)
0.0 0.4 GO:0000800 lateral element(GO:0000800)
0.0 0.1 GO:0071942 XPC complex(GO:0071942)
0.0 0.1 GO:0034676 integrin alpha6-beta4 complex(GO:0034676)
0.0 0.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)
0.0 0.1 GO:0031213 RSF complex(GO:0031213)
0.0 0.1 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.1 GO:0033186 CAF-1 complex(GO:0033186)
0.0 0.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.3 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.2 GO:0000796 condensin complex(GO:0000796)
0.0 0.2 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.1 GO:0005797 Golgi medial cisterna(GO:0005797)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0030626 U12 snRNA binding(GO:0030626)
0.1 0.3 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
0.1 0.3 GO:0004662 CAAX-protein geranylgeranyltransferase activity(GO:0004662)
0.1 0.2 GO:0032181 double-strand/single-strand DNA junction binding(GO:0000406) dinucleotide repeat insertion binding(GO:0032181)
0.1 0.2 GO:0004170 dUTP diphosphatase activity(GO:0004170)
0.1 0.2 GO:0034736 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.1 0.2 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.1 0.2 GO:0070283 lipoate synthase activity(GO:0016992) radical SAM enzyme activity(GO:0070283)
0.1 0.2 GO:0004583 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583)
0.1 0.8 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.1 0.2 GO:0045485 omega-6 fatty acid desaturase activity(GO:0045485)
0.1 0.2 GO:0004307 ethanolaminephosphotransferase activity(GO:0004307)
0.0 0.1 GO:0032142 single guanine insertion binding(GO:0032142) single thymine insertion binding(GO:0032143)
0.0 0.5 GO:0000405 bubble DNA binding(GO:0000405)
0.0 0.2 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.0 0.2 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.0 0.6 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.1 GO:0048763 HLH domain binding(GO:0043398) calcium-induced calcium release activity(GO:0048763)
0.0 0.2 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0 0.2 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.0 0.3 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0 0.6 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.2 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.0 0.2 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.1 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.0 0.1 GO:0031705 bombesin receptor binding(GO:0031705)
0.0 0.1 GO:0052642 lysophosphatidic acid phosphatase activity(GO:0052642)
0.0 0.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.1 GO:0051870 methotrexate binding(GO:0051870)
0.0 0.1 GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263)
0.0 0.3 GO:0000150 recombinase activity(GO:0000150)
0.0 0.1 GO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity(GO:0004572)
0.0 0.1 GO:0003896 DNA primase activity(GO:0003896)
0.0 0.0 GO:0032093 SAM domain binding(GO:0032093)
0.0 0.2 GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144)
0.0 0.4 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 0.1 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.0 0.2 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.1 GO:0008384 IkappaB kinase activity(GO:0008384)
0.0 0.0 GO:0004139 deoxyribose-phosphate aldolase activity(GO:0004139)
0.0 0.1 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.2 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.0 GO:0004817 cysteine-tRNA ligase activity(GO:0004817)
0.0 0.6 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.1 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.1 GO:0050145 nucleoside phosphate kinase activity(GO:0050145)
0.0 0.1 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.0 0.1 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 ST JAK STAT PATHWAY Jak-STAT Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 1.1 REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND Genes involved in Processive synthesis on the lagging strand
0.0 0.6 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.4 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.5 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.4 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 0.8 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.2 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions