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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for E2F3
Z-value: 2.09
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Transcription factors associated with E2F3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F3 | hg19_v2_chr6_+_20403997_20404034 | 0.02 | 9.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_+_4692230 Show fit | 1.64 |
ENST00000331264.7
|
glycolipid transfer protein domain containing 2 |
|
| chr19_-_48673465 Show fit | 1.26 |
ENST00000598938.1
|
ligase I, DNA, ATP-dependent |
|
| chr16_+_48657361 Show fit | 1.22 |
ENST00000565072.1
|
RP11-42I10.1 |
|
| chr2_+_163200598 Show fit | 1.05 |
ENST00000437150.2
ENST00000453113.2 |
grancalcin, EF-hand calcium binding protein |
|
| chr4_+_89300158 Show fit | 0.96 |
ENST00000502870.1
|
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 |
|
| chr2_+_67624430 Show fit | 0.95 |
ENST00000272342.5
|
Ewing tumor-associated antigen 1 |
|
| chr18_-_54318353 Show fit | 0.94 |
ENST00000590954.1
ENST00000540155.1 |
thioredoxin-like 1 |
|
| chr5_-_141703713 Show fit | 0.85 |
ENST00000511815.1
|
sprouty homolog 4 (Drosophila) |
|
| chr2_-_208490027 Show fit | 0.83 |
ENST00000458426.1
ENST00000406927.2 ENST00000425132.1 |
methyltransferase like 21A |
|
| chr2_-_197036289 Show fit | 0.79 |
ENST00000263955.4
|
serine/threonine kinase 17b |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.8 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 0.1 | 1.5 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
| 0.2 | 1.4 | GO:1904386 | response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386) |
| 0.1 | 1.2 | GO:0051382 | kinetochore assembly(GO:0051382) |
| 0.0 | 1.2 | GO:0006465 | signal peptide processing(GO:0006465) |
| 0.2 | 1.1 | GO:1903786 | mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788) |
| 0.1 | 1.1 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
| 0.3 | 1.0 | GO:2001247 | positive regulation of phosphatidylcholine biosynthetic process(GO:2001247) |
| 0.2 | 1.0 | GO:0015788 | UDP-N-acetylglucosamine transport(GO:0015788) UDP-N-acetylglucosamine transmembrane transport(GO:1990569) |
| 0.1 | 1.0 | GO:0090267 | positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.1 | 1.7 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.0 | 1.7 | GO:0005844 | polysome(GO:0005844) |
| 0.0 | 1.7 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 1.7 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 1.4 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 1.3 | GO:0016234 | inclusion body(GO:0016234) |
| 0.0 | 1.3 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 1.3 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 1.2 | GO:0005787 | signal peptidase complex(GO:0005787) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.7 | GO:0003910 | DNA ligase (ATP) activity(GO:0003910) |
| 0.0 | 1.7 | GO:0019003 | GDP binding(GO:0019003) |
| 0.1 | 1.5 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.0 | 1.4 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.4 | 1.1 | GO:0043337 | cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572) CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity(GO:0043337) |
| 0.0 | 1.1 | GO:0035173 | histone kinase activity(GO:0035173) |
| 0.0 | 1.1 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 1.1 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.2 | 1.0 | GO:0005462 | UDP-N-acetylglucosamine transmembrane transporter activity(GO:0005462) |
| 0.0 | 1.0 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.0 | 2.1 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 1.9 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 1.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.5 | PID FAS PATHWAY | FAS (CD95) signaling pathway |
| 0.0 | 1.4 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 1.4 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.1 | 1.3 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 1.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 1.0 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.2 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.0 | 3.1 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 2.1 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.1 | 2.0 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.0 | 1.9 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 1.7 | REACTOME EARLY PHASE OF HIV LIFE CYCLE | Genes involved in Early Phase of HIV Life Cycle |
| 0.1 | 1.4 | REACTOME ACYL CHAIN REMODELLING OF PG | Genes involved in Acyl chain remodelling of PG |
| 0.0 | 1.4 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 1.3 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 0.0 | 1.3 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |