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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for DMC1

Z-value: 0.24

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Transcription factors associated with DMC1

Gene Symbol Gene ID Gene Info
DMC1
ENSG00000100206.5 DNA meiotic recombinase 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DMC1hg19_v2_chr22_-_38966123_389661630.443.8e-01Click!

Activity profile of DMC1 motif

Sorted Z-values of DMC1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_61244550 0.14 ENST00000421319.1
PUS10
pseudouridylate synthase 10
chr14_+_21525981 0.14 ENST00000308227.2
RNASE8
ribonuclease, RNase A family, 8
chr5_-_149465990 0.13 ENST00000543093.1
CSF1R
colony stimulating factor 1 receptor
chr2_+_171640291 0.12 ENST00000409885.1
ERICH2
glutamate-rich 2
chr14_+_74318611 0.11 ENST00000555976.1
ENST00000267568.4
PTGR2
prostaglandin reductase 2
chr11_-_73720276 0.11 ENST00000348534.4
UCP3
uncoupling protein 3 (mitochondrial, proton carrier)
chr14_-_68157084 0.11 ENST00000557564.1
RP11-1012A1.4
RP11-1012A1.4
chr10_+_74870206 0.11 ENST00000357321.4
ENST00000349051.5
NUDT13
nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr4_+_15471489 0.10 ENST00000424120.1
ENST00000413206.1
ENST00000438599.2
ENST00000511544.1
ENST00000512702.1
ENST00000507954.1
ENST00000515124.1
ENST00000503292.1
ENST00000503658.1
CC2D2A
coiled-coil and C2 domain containing 2A
chr11_-_73720122 0.10 ENST00000426995.2
UCP3
uncoupling protein 3 (mitochondrial, proton carrier)
chr14_+_74318513 0.09 ENST00000555228.1
ENST00000555661.1
PTGR2
prostaglandin reductase 2
chr10_+_62538248 0.08 ENST00000448257.2
CDK1
cyclin-dependent kinase 1
chr10_+_74870253 0.06 ENST00000544879.1
ENST00000537969.1
ENST00000372997.3
NUDT13
nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr11_-_85780086 0.06 ENST00000532317.1
ENST00000528256.1
ENST00000526033.1
PICALM
phosphatidylinositol binding clathrin assembly protein
chr3_-_156840776 0.06 ENST00000471357.1
LINC00880
long intergenic non-protein coding RNA 880
chr10_-_98031310 0.06 ENST00000427367.2
ENST00000413476.2
BLNK
B-cell linker
chr15_-_49103235 0.05 ENST00000380950.2
CEP152
centrosomal protein 152kDa
chr3_+_9944492 0.05 ENST00000383814.3
ENST00000454190.2
ENST00000454992.1
IL17RE
interleukin 17 receptor E
chr2_+_136343904 0.05 ENST00000436436.1
R3HDM1
R3H domain containing 1
chr2_+_219247021 0.05 ENST00000539932.1
SLC11A1
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
chr17_+_74075263 0.05 ENST00000334586.5
ENST00000392503.2
ZACN
zinc activated ligand-gated ion channel
chr11_+_71238313 0.05 ENST00000398536.4
KRTAP5-7
keratin associated protein 5-7
chr21_-_35281399 0.05 ENST00000418933.1
ATP5O
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
chr12_-_8803128 0.05 ENST00000543467.1
MFAP5
microfibrillar associated protein 5
chr3_+_9944303 0.05 ENST00000421412.1
ENST00000295980.3
IL17RE
interleukin 17 receptor E
chr10_-_62332357 0.05 ENST00000503366.1
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr6_+_46661575 0.05 ENST00000450697.1
TDRD6
tudor domain containing 6
chr10_-_74856608 0.04 ENST00000307116.2
ENST00000373008.2
ENST00000412021.2
ENST00000394890.2
ENST00000263556.3
ENST00000440381.1
P4HA1
prolyl 4-hydroxylase, alpha polypeptide I
chr11_-_85779971 0.04 ENST00000393346.3
PICALM
phosphatidylinositol binding clathrin assembly protein
chr10_+_62538089 0.04 ENST00000519078.2
ENST00000395284.3
ENST00000316629.4
CDK1
cyclin-dependent kinase 1
chr7_-_150884332 0.04 ENST00000275838.1
ENST00000422024.1
ENST00000434669.1
ASB10
ankyrin repeat and SOCS box containing 10
chr10_-_98031265 0.04 ENST00000224337.5
ENST00000371176.2
BLNK
B-cell linker
chr17_+_57297807 0.04 ENST00000284116.4
ENST00000581140.1
ENST00000581276.1
GDPD1
glycerophosphodiester phosphodiesterase domain containing 1
chr2_+_61244697 0.04 ENST00000401576.1
ENST00000295030.5
ENST00000414712.2
PEX13
peroxisomal biogenesis factor 13
chrX_-_134305322 0.04 ENST00000276241.6
ENST00000344129.2
CXorf48
cancer/testis antigen 55
chr12_-_50677255 0.03 ENST00000551691.1
ENST00000394943.3
ENST00000341247.4
LIMA1
LIM domain and actin binding 1
chr15_-_42448788 0.03 ENST00000382396.4
ENST00000397272.3
PLA2G4F
phospholipase A2, group IVF
chr2_-_21022818 0.03 ENST00000440866.2
ENST00000541941.1
ENST00000402479.2
ENST00000435420.2
ENST00000432947.1
ENST00000403006.2
ENST00000419825.2
ENST00000381090.3
ENST00000237822.3
ENST00000412261.1
C2orf43
chromosome 2 open reading frame 43
chr8_-_101734907 0.03 ENST00000318607.5
ENST00000521865.1
ENST00000520804.1
ENST00000522720.1
ENST00000521067.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr2_+_219246746 0.03 ENST00000233202.6
SLC11A1
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
chr19_+_44617511 0.03 ENST00000262894.6
ENST00000588926.1
ENST00000592780.1
ZNF225
zinc finger protein 225
chr11_+_101785727 0.03 ENST00000263468.8
KIAA1377
KIAA1377
chr2_+_187454749 0.03 ENST00000261023.3
ENST00000374907.3
ITGAV
integrin, alpha V
chr17_-_60142609 0.03 ENST00000397786.2
MED13
mediator complex subunit 13
chr22_+_21133469 0.03 ENST00000406799.1
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr1_-_47131521 0.03 ENST00000542495.1
ENST00000532925.1
ATPAF1
ATP synthase mitochondrial F1 complex assembly factor 1
chr1_-_11863571 0.02 ENST00000376583.3
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr2_-_75788038 0.02 ENST00000393913.3
ENST00000410113.1
EVA1A
eva-1 homolog A (C. elegans)
chr1_+_12290121 0.02 ENST00000358136.3
ENST00000356315.4
VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr18_+_11857439 0.02 ENST00000602628.1
GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr2_+_48667898 0.02 ENST00000281394.4
ENST00000294952.8
PPP1R21
protein phosphatase 1, regulatory subunit 21
chr5_+_55149356 0.02 ENST00000490985.1
ENST00000354961.4
IL31RA
interleukin 31 receptor A
chr7_-_15601595 0.02 ENST00000342526.3
AGMO
alkylglycerol monooxygenase
chr3_-_99569821 0.02 ENST00000487087.1
FILIP1L
filamin A interacting protein 1-like
chrX_+_105855160 0.02 ENST00000372544.2
ENST00000372548.4
CXorf57
chromosome X open reading frame 57
chr7_-_150884873 0.02 ENST00000377867.3
ASB10
ankyrin repeat and SOCS box containing 10
chr19_-_3600549 0.02 ENST00000589966.1
TBXA2R
thromboxane A2 receptor
chr21_-_46348626 0.02 ENST00000517563.1
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr8_+_67104940 0.01 ENST00000517689.1
LINC00967
long intergenic non-protein coding RNA 967
chr2_-_61244308 0.01 ENST00000407787.1
ENST00000398658.2
PUS10
pseudouridylate synthase 10
chr6_+_88054530 0.01 ENST00000388923.4
C6orf163
chromosome 6 open reading frame 163
chr6_-_150067696 0.01 ENST00000340413.2
ENST00000367403.3
NUP43
nucleoporin 43kDa
chr3_-_141747459 0.01 ENST00000477292.1
ENST00000478006.1
ENST00000495310.1
ENST00000486111.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr11_+_71846764 0.01 ENST00000456237.1
ENST00000442948.2
ENST00000546166.1
FOLR3
folate receptor 3 (gamma)
chr1_-_19811132 0.01 ENST00000433834.1
CAPZB
capping protein (actin filament) muscle Z-line, beta
chr14_-_21492113 0.01 ENST00000554094.1
NDRG2
NDRG family member 2
chr2_+_201173667 0.00 ENST00000409755.3
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr10_+_11047259 0.00 ENST00000379261.4
ENST00000416382.2
CELF2
CUGBP, Elav-like family member 2
chr4_+_106473768 0.00 ENST00000265154.2
ENST00000420470.2
ARHGEF38
Rho guanine nucleotide exchange factor (GEF) 38

Network of associatons between targets according to the STRING database.

First level regulatory network of DMC1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0061760 antifungal innate immune response(GO:0061760)
0.0 0.1 GO:0070839 divalent metal ion export(GO:0070839)
0.0 0.1 GO:0014038 regulation of Schwann cell differentiation(GO:0014038)
0.0 0.1 GO:1902963 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.0 0.2 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.1 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.0 0.1 GO:0097396 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.0 0.1 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145)
0.0 0.2 GO:1990845 adaptive thermogenesis(GO:1990845)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.0 0.1 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 0.1 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.0 0.0 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0 0.0 GO:0034686 integrin alphav-beta6 complex(GO:0034685) integrin alphav-beta8 complex(GO:0034686)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.0 0.2 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.0 0.1 GO:0051139 metal ion:proton antiporter activity(GO:0051139)
0.0 0.1 GO:0005011 macrophage colony-stimulating factor receptor activity(GO:0005011)
0.0 0.1 GO:0004522 ribonuclease A activity(GO:0004522)
0.0 0.0 GO:1990430 extracellular matrix protein binding(GO:1990430)