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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for DMC1

Z-value: 0.24

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Transcription factors associated with DMC1

Gene Symbol Gene ID Gene Info
DMC1
ENSG00000100206.5 DMC1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DMC1hg19_v2_chr22_-_38966123_389661630.443.8e-01Click!

Activity profile of DMC1 motif

Sorted Z-values of DMC1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of DMC1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr2_-_61244550 0.14 ENST00000421319.1
 PUS10
 pseudouridylate synthase 10
chr14_+_21525981 0.14 ENST00000308227.2
 RNASE8
 ribonuclease, RNase A family, 8
chr5_-_149465990 0.13 ENST00000543093.1
 CSF1R
 colony stimulating factor 1 receptor
chr2_+_171640291 0.12 ENST00000409885.1
 ERICH2
 glutamate-rich 2
chr14_+_74318611 0.11 ENST00000555976.1
ENST00000267568.4
 PTGR2
 prostaglandin reductase 2
chr11_-_73720276 0.11 ENST00000348534.4
 UCP3
 uncoupling protein 3 (mitochondrial, proton carrier)
chr14_-_68157084 0.11 ENST00000557564.1
 RP11-1012A1.4
 RP11-1012A1.4
chr10_+_74870206 0.11 ENST00000357321.4
ENST00000349051.5
 NUDT13
 nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr4_+_15471489 0.10 ENST00000424120.1
ENST00000413206.1
ENST00000438599.2
ENST00000511544.1
ENST00000512702.1
ENST00000507954.1
ENST00000515124.1
ENST00000503292.1
ENST00000503658.1
 CC2D2A
 coiled-coil and C2 domain containing 2A
chr11_-_73720122 0.10 ENST00000426995.2
 UCP3
 uncoupling protein 3 (mitochondrial, proton carrier)
chr14_+_74318513 0.09 ENST00000555228.1
ENST00000555661.1
 PTGR2
 prostaglandin reductase 2
chr10_+_62538248 0.08 ENST00000448257.2
 CDK1
 cyclin-dependent kinase 1
chr10_+_74870253 0.06 ENST00000544879.1
ENST00000537969.1
ENST00000372997.3
 NUDT13
 nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr11_-_85780086 0.06 ENST00000532317.1
ENST00000528256.1
ENST00000526033.1
 PICALM
 phosphatidylinositol binding clathrin assembly protein
chr3_-_156840776 0.06 ENST00000471357.1
 LINC00880
 long intergenic non-protein coding RNA 880
chr10_-_98031310 0.06 ENST00000427367.2
ENST00000413476.2
 BLNK
 B-cell linker
chr15_-_49103235 0.05 ENST00000380950.2
 CEP152
 centrosomal protein 152kDa
chr3_+_9944492 0.05 ENST00000383814.3
ENST00000454190.2
ENST00000454992.1
 IL17RE
 interleukin 17 receptor E
chr2_+_136343904 0.05 ENST00000436436.1
 R3HDM1
 R3H domain containing 1
chr2_+_219247021 0.05 ENST00000539932.1
 SLC11A1
 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
chr17_+_74075263 0.05 ENST00000334586.5
ENST00000392503.2
 ZACN
 zinc activated ligand-gated ion channel
chr11_+_71238313 0.05 ENST00000398536.4
 KRTAP5-7
 keratin associated protein 5-7
chr21_-_35281399 0.05 ENST00000418933.1
 ATP5O
 ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
chr12_-_8803128 0.05 ENST00000543467.1
 MFAP5
 microfibrillar associated protein 5
chr3_+_9944303 0.05 ENST00000421412.1
ENST00000295980.3
 IL17RE
 interleukin 17 receptor E
chr10_-_62332357 0.05 ENST00000503366.1
 ANK3
 ankyrin 3, node of Ranvier (ankyrin G)
chr6_+_46661575 0.05 ENST00000450697.1
 TDRD6
 tudor domain containing 6
chr10_-_74856608 0.04 ENST00000307116.2
ENST00000373008.2
ENST00000412021.2
ENST00000394890.2
ENST00000263556.3
ENST00000440381.1
 P4HA1
 prolyl 4-hydroxylase, alpha polypeptide I
chr11_-_85779971 0.04 ENST00000393346.3
 PICALM
 phosphatidylinositol binding clathrin assembly protein
chr10_+_62538089 0.04 ENST00000519078.2
ENST00000395284.3
ENST00000316629.4
 CDK1
 cyclin-dependent kinase 1
chr7_-_150884332 0.04 ENST00000275838.1
ENST00000422024.1
ENST00000434669.1
 ASB10
 ankyrin repeat and SOCS box containing 10
chr10_-_98031265 0.04 ENST00000224337.5
ENST00000371176.2
 BLNK
 B-cell linker
chr17_+_57297807 0.04 ENST00000284116.4
ENST00000581140.1
ENST00000581276.1
 GDPD1
 glycerophosphodiester phosphodiesterase domain containing 1
chr2_+_61244697 0.04 ENST00000401576.1
ENST00000295030.5
ENST00000414712.2
 PEX13
 peroxisomal biogenesis factor 13
chrX_-_134305322 0.04 ENST00000276241.6
ENST00000344129.2
 CXorf48
 cancer/testis antigen 55
chr12_-_50677255 0.03 ENST00000551691.1
ENST00000394943.3
ENST00000341247.4
 LIMA1
 LIM domain and actin binding 1
chr15_-_42448788 0.03 ENST00000382396.4
ENST00000397272.3
 PLA2G4F
 phospholipase A2, group IVF
chr2_-_21022818 0.03 ENST00000440866.2
ENST00000541941.1
ENST00000402479.2
ENST00000435420.2
ENST00000432947.1
ENST00000403006.2
ENST00000419825.2
ENST00000381090.3
ENST00000237822.3
ENST00000412261.1
 C2orf43
 chromosome 2 open reading frame 43
chr8_-_101734907 0.03 ENST00000318607.5
ENST00000521865.1
ENST00000520804.1
ENST00000522720.1
ENST00000521067.1
 PABPC1
 poly(A) binding protein, cytoplasmic 1
chr2_+_219246746 0.03 ENST00000233202.6
 SLC11A1
 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
chr19_+_44617511 0.03 ENST00000262894.6
ENST00000588926.1
ENST00000592780.1
 ZNF225
 zinc finger protein 225
chr11_+_101785727 0.03 ENST00000263468.8
 KIAA1377
 KIAA1377
chr2_+_187454749 0.03 ENST00000261023.3
ENST00000374907.3
 ITGAV
 integrin, alpha V
chr17_-_60142609 0.03 ENST00000397786.2
 MED13
 mediator complex subunit 13
chr22_+_21133469 0.03 ENST00000406799.1
 SERPIND1
 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr1_-_47131521 0.03 ENST00000542495.1
ENST00000532925.1
 ATPAF1
 ATP synthase mitochondrial F1 complex assembly factor 1
chr1_-_11863571 0.02 ENST00000376583.3
 MTHFR
 methylenetetrahydrofolate reductase (NAD(P)H)
chr2_-_75788038 0.02 ENST00000393913.3
ENST00000410113.1
 EVA1A
 eva-1 homolog A (C. elegans)
chr1_+_12290121 0.02 ENST00000358136.3
ENST00000356315.4
 VPS13D
 vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr18_+_11857439 0.02 ENST00000602628.1
 GNAL
 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr2_+_48667898 0.02 ENST00000281394.4
ENST00000294952.8
 PPP1R21
 protein phosphatase 1, regulatory subunit 21
chr5_+_55149356 0.02 ENST00000490985.1
ENST00000354961.4
 IL31RA
 interleukin 31 receptor A
chr7_-_15601595 0.02 ENST00000342526.3
 AGMO
 alkylglycerol monooxygenase
chr3_-_99569821 0.02 ENST00000487087.1
 FILIP1L
 filamin A interacting protein 1-like
chrX_+_105855160 0.02 ENST00000372544.2
ENST00000372548.4
 CXorf57
 chromosome X open reading frame 57
chr7_-_150884873 0.02 ENST00000377867.3
 ASB10
 ankyrin repeat and SOCS box containing 10
chr19_-_3600549 0.02 ENST00000589966.1
 TBXA2R
 thromboxane A2 receptor
chr21_-_46348626 0.02 ENST00000517563.1
 ITGB2
 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr8_+_67104940 0.01 ENST00000517689.1
 LINC00967
 long intergenic non-protein coding RNA 967
chr2_-_61244308 0.01 ENST00000407787.1
ENST00000398658.2
 PUS10
 pseudouridylate synthase 10
chr6_+_88054530 0.01 ENST00000388923.4
 C6orf163
 chromosome 6 open reading frame 163
chr6_-_150067696 0.01 ENST00000340413.2
ENST00000367403.3
 NUP43
 nucleoporin 43kDa
chr3_-_141747459 0.01 ENST00000477292.1
ENST00000478006.1
ENST00000495310.1
ENST00000486111.1
 TFDP2
 transcription factor Dp-2 (E2F dimerization partner 2)
chr11_+_71846764 0.01 ENST00000456237.1
ENST00000442948.2
ENST00000546166.1
 FOLR3
 folate receptor 3 (gamma)
chr1_-_19811132 0.01 ENST00000433834.1
 CAPZB
 capping protein (actin filament) muscle Z-line, beta
chr14_-_21492113 0.01 ENST00000554094.1
 NDRG2
 NDRG family member 2
chr2_+_201173667 0.00 ENST00000409755.3
 SPATS2L
 spermatogenesis associated, serine-rich 2-like
chr10_+_11047259 0.00 ENST00000379261.4
ENST00000416382.2
 CELF2
 CUGBP, Elav-like family member 2
chr4_+_106473768 0.00 ENST00000265154.2
ENST00000420470.2
 ARHGEF38
 Rho guanine nucleotide exchange factor (GEF) 38

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0061760 antifungal innate immune response(GO:0061760)
0.0 0.1 GO:0070839 divalent metal ion export(GO:0070839)
0.0 0.1 GO:0014038 regulation of Schwann cell differentiation(GO:0014038)
0.0 0.1 GO:1902963 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.0 0.2 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.1 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.0 0.1 GO:0097396 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.0 0.1 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145)
0.0 0.2 GO:1990845 adaptive thermogenesis(GO:1990845)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.0 0.1 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 0.1 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.0 0.0 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0 0.0 GO:0034686 integrin alphav-beta6 complex(GO:0034685) integrin alphav-beta8 complex(GO:0034686)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.0 0.2 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.0 0.1 GO:0051139 metal ion:proton antiporter activity(GO:0051139)
0.0 0.1 GO:0005011 macrophage colony-stimulating factor receptor activity(GO:0005011)
0.0 0.1 GO:0004522 ribonuclease A activity(GO:0004522)
0.0 0.0 GO:1990430 extracellular matrix protein binding(GO:1990430)