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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for DMBX1

Z-value: 0.41

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Transcription factors associated with DMBX1

Gene Symbol Gene ID Gene Info
DMBX1
ENSG00000197587.6 diencephalon/mesencephalon homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DMBX1hg19_v2_chr1_+_46972668_46972669-0.226.8e-01Click!

Activity profile of DMBX1 motif

Sorted Z-values of DMBX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_38859996 0.30 ENST00000264651.2
KRT24
keratin 24
chr6_+_89791507 0.27 ENST00000354922.3
PNRC1
proline-rich nuclear receptor coactivator 1
chr15_+_63414760 0.25 ENST00000557972.1
LACTB
lactamase, beta
chr4_-_170679024 0.23 ENST00000393381.2
C4orf27
chromosome 4 open reading frame 27
chr3_+_136649311 0.20 ENST00000469404.1
ENST00000467911.1
NCK1
NCK adaptor protein 1
chr12_-_76461249 0.20 ENST00000551524.1
NAP1L1
nucleosome assembly protein 1-like 1
chr11_+_61248583 0.19 ENST00000432063.2
ENST00000338608.2
PPP1R32
protein phosphatase 1, regulatory subunit 32
chr15_-_49102781 0.13 ENST00000558591.1
CEP152
centrosomal protein 152kDa
chr3_+_138340067 0.12 ENST00000479848.1
FAIM
Fas apoptotic inhibitory molecule
chr1_+_180875711 0.12 ENST00000434447.1
RP11-46A10.2
RP11-46A10.2
chr19_+_41284121 0.12 ENST00000594800.1
ENST00000357052.2
ENST00000602173.1
RAB4B
RAB4B, member RAS oncogene family
chr3_+_111393501 0.12 ENST00000393934.3
PLCXD2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr2_+_223725723 0.12 ENST00000535678.1
ACSL3
acyl-CoA synthetase long-chain family member 3
chr1_-_47655686 0.12 ENST00000294338.2
PDZK1IP1
PDZK1 interacting protein 1
chr9_-_21995249 0.11 ENST00000494262.1
CDKN2A
cyclin-dependent kinase inhibitor 2A
chr6_-_33297013 0.11 ENST00000453407.1
DAXX
death-domain associated protein
chr16_-_31076332 0.10 ENST00000539836.3
ENST00000535577.1
ENST00000442862.2
ZNF668
zinc finger protein 668
chr7_-_48068643 0.10 ENST00000453192.2
SUN3
Sad1 and UNC84 domain containing 3
chr15_-_85201779 0.10 ENST00000360476.3
ENST00000394588.3
NMB
neuromedin B
chr9_+_74920335 0.10 ENST00000451596.2
ENST00000436054.1
RP11-63P12.6
RP11-63P12.6
chr10_+_86004802 0.09 ENST00000359452.4
ENST00000358110.5
ENST00000372092.3
RGR
retinal G protein coupled receptor
chr12_-_49581152 0.09 ENST00000550811.1
TUBA1A
tubulin, alpha 1a
chr4_+_108815402 0.09 ENST00000503385.1
SGMS2
sphingomyelin synthase 2
chr19_-_51538148 0.08 ENST00000319590.4
ENST00000250351.4
KLK12
kallikrein-related peptidase 12
chr15_-_60771280 0.08 ENST00000560072.1
ENST00000560406.1
ENST00000560520.1
ENST00000261520.4
ENST00000439632.1
NARG2
NMDA receptor regulated 2
chr3_-_16524357 0.08 ENST00000432519.1
RFTN1
raftlin, lipid raft linker 1
chr6_-_26250835 0.08 ENST00000446824.2
HIST1H3F
histone cluster 1, H3f
chr1_+_206138457 0.07 ENST00000367128.3
ENST00000431655.2
FAM72A
family with sequence similarity 72, member A
chr19_-_51538118 0.07 ENST00000529888.1
KLK12
kallikrein-related peptidase 12
chr17_+_16945820 0.07 ENST00000577514.1
MPRIP
myosin phosphatase Rho interacting protein
chr8_-_125577940 0.07 ENST00000519168.1
ENST00000395508.2
MTSS1
metastasis suppressor 1
chr3_+_138340049 0.07 ENST00000464668.1
FAIM
Fas apoptotic inhibitory molecule
chr16_-_31076273 0.07 ENST00000426488.2
ZNF668
zinc finger protein 668
chr2_+_37571845 0.07 ENST00000537448.1
QPCT
glutaminyl-peptide cyclotransferase
chr17_-_48207157 0.06 ENST00000330175.4
ENST00000503131.1
SAMD14
sterile alpha motif domain containing 14
chr4_+_41937131 0.06 ENST00000504986.1
ENST00000508448.1
ENST00000513702.1
ENST00000325094.5
TMEM33
transmembrane protein 33
chr7_-_135412925 0.06 ENST00000354042.4
SLC13A4
solute carrier family 13 (sodium/sulfate symporter), member 4
chr12_+_53693812 0.05 ENST00000549488.1
C12orf10
chromosome 12 open reading frame 10
chr10_+_118187379 0.05 ENST00000369230.3
PNLIPRP3
pancreatic lipase-related protein 3
chr1_-_143913143 0.05 ENST00000400889.1
FAM72D
family with sequence similarity 72, member D
chr4_-_120225600 0.05 ENST00000399075.4
C4orf3
chromosome 4 open reading frame 3
chr17_-_4643114 0.05 ENST00000293778.6
CXCL16
chemokine (C-X-C motif) ligand 16
chr3_+_188664988 0.05 ENST00000433971.1
TPRG1
tumor protein p63 regulated 1
chr8_-_23282797 0.04 ENST00000524144.1
LOXL2
lysyl oxidase-like 2
chr3_+_111393659 0.04 ENST00000477665.1
PLCXD2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr1_-_94586651 0.04 ENST00000535735.1
ENST00000370225.3
ABCA4
ATP-binding cassette, sub-family A (ABC1), member 4
chr8_-_23282820 0.03 ENST00000520871.1
LOXL2
lysyl oxidase-like 2
chr3_+_99986036 0.03 ENST00000471098.1
TBC1D23
TBC1 domain family, member 23
chr12_+_7941989 0.03 ENST00000229307.4
NANOG
Nanog homeobox
chr3_-_10362725 0.03 ENST00000397109.3
ENST00000428626.1
ENST00000445064.1
ENST00000431352.1
ENST00000397117.1
ENST00000337354.4
ENST00000383801.2
ENST00000432213.1
ENST00000350697.3
SEC13
SEC13 homolog (S. cerevisiae)
chr1_-_28384598 0.03 ENST00000373864.1
EYA3
eyes absent homolog 3 (Drosophila)
chr10_+_103986085 0.03 ENST00000370005.3
ELOVL3
ELOVL fatty acid elongase 3
chr1_+_120839005 0.03 ENST00000369390.3
ENST00000452190.1
FAM72B
family with sequence similarity 72, member B
chr19_+_17448348 0.03 ENST00000324894.8
ENST00000358792.7
ENST00000600625.1
GTPBP3
GTP binding protein 3 (mitochondrial)
chr2_+_73461410 0.03 ENST00000399032.2
ENST00000398422.2
ENST00000537131.1
ENST00000538797.1
CCT7
chaperonin containing TCP1, subunit 7 (eta)
chr7_+_21582638 0.03 ENST00000409508.3
ENST00000328843.6
DNAH11
dynein, axonemal, heavy chain 11
chr10_-_99030395 0.03 ENST00000355366.5
ENST00000371027.1
ARHGAP19
Rho GTPase activating protein 19
chr2_+_73461364 0.03 ENST00000540468.1
ENST00000539919.1
ENST00000258091.5
CCT7
chaperonin containing TCP1, subunit 7 (eta)
chr3_+_49057876 0.03 ENST00000326912.4
NDUFAF3
NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
chr7_-_17500294 0.03 ENST00000439046.1
AC019117.2
AC019117.2
chr11_-_36619771 0.02 ENST00000311485.3
ENST00000527033.1
ENST00000532616.1
RAG2
recombination activating gene 2
chr15_-_61521495 0.02 ENST00000335670.6
RORA
RAR-related orphan receptor A
chr15_-_60683326 0.02 ENST00000559350.1
ENST00000558986.1
ENST00000560389.1
ANXA2
annexin A2
chr4_+_124571409 0.02 ENST00000514823.1
ENST00000511919.1
ENST00000508111.1
RP11-93L9.1
long intergenic non-protein coding RNA 1091
chr5_-_54988448 0.02 ENST00000503817.1
ENST00000512595.1
SLC38A9
solute carrier family 38, member 9
chrX_-_64754611 0.02 ENST00000374807.5
ENST00000374811.3
ENST00000374804.5
ENST00000312391.8
LAS1L
LAS1-like (S. cerevisiae)
chr19_+_36157715 0.02 ENST00000379013.2
ENST00000222275.2
UPK1A
uroplakin 1A
chr12_-_56321649 0.02 ENST00000454792.2
ENST00000408946.2
WIBG
within bgcn homolog (Drosophila)
chr17_-_48207115 0.02 ENST00000511964.1
SAMD14
sterile alpha motif domain containing 14
chr9_+_74920408 0.02 ENST00000451152.1
RP11-63P12.6
RP11-63P12.6
chr7_-_99774945 0.02 ENST00000292377.2
GPC2
glypican 2
chr6_-_138893661 0.02 ENST00000427025.2
NHSL1
NHS-like 1
chr10_+_74451883 0.02 ENST00000373053.3
ENST00000357157.6
MCU
mitochondrial calcium uniporter
chr5_+_71403280 0.02 ENST00000511641.2
MAP1B
microtubule-associated protein 1B
chr17_-_12921270 0.02 ENST00000578071.1
ENST00000426905.3
ENST00000395962.2
ENST00000583371.1
ENST00000338034.4
ELAC2
elaC ribonuclease Z 2
chr5_+_50678921 0.01 ENST00000230658.7
ISL1
ISL LIM homeobox 1
chr2_+_223725652 0.01 ENST00000357430.3
ENST00000392066.3
ACSL3
acyl-CoA synthetase long-chain family member 3
chr15_+_63413990 0.01 ENST00000261893.4
LACTB
lactamase, beta
chr1_-_47779762 0.01 ENST00000371877.3
ENST00000360380.3
ENST00000337817.5
ENST00000447475.2
STIL
SCL/TAL1 interrupting locus
chr3_-_149470229 0.01 ENST00000473414.1
COMMD2
COMM domain containing 2
chr12_-_118628315 0.00 ENST00000540561.1
TAOK3
TAO kinase 3
chr19_-_6459746 0.00 ENST00000301454.4
ENST00000334510.5
SLC25A23
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
chr4_+_140586922 0.00 ENST00000265498.1
ENST00000506797.1
MGST2
microsomal glutathione S-transferase 2
chr20_+_34556488 0.00 ENST00000373973.3
ENST00000349339.1
ENST00000538900.1
CNBD2
cyclic nucleotide binding domain containing 2
chr1_+_109756523 0.00 ENST00000234677.2
ENST00000369923.4
SARS
seryl-tRNA synthetase
chr6_-_111927062 0.00 ENST00000359831.4
TRAF3IP2
TRAF3 interacting protein 2
chr10_-_35104185 0.00 ENST00000374789.3
ENST00000374788.3
ENST00000346874.4
ENST00000374794.3
ENST00000350537.4
ENST00000374790.3
ENST00000374776.1
ENST00000374773.1
ENST00000545693.1
ENST00000545260.1
ENST00000340077.5
PARD3
par-3 family cell polarity regulator
chr5_+_175740083 0.00 ENST00000332772.4
SIMC1
SUMO-interacting motifs containing 1
chr18_-_35145728 0.00 ENST00000361795.5
ENST00000603232.1
CELF4
CUGBP, Elav-like family member 4

Network of associatons between targets according to the STRING database.

First level regulatory network of DMBX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:1903676 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.0 0.1 GO:2001247 positive regulation of phosphatidylcholine biosynthetic process(GO:2001247)
0.0 0.1 GO:0072737 response to diamide(GO:0072737) cellular response to diamide(GO:0072738)
0.0 0.3 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.1 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.0 0.1 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.0 0.1 GO:0018277 protein deamination(GO:0018277)
0.0 0.1 GO:0098535 de novo centriole assembly(GO:0098535)
0.0 0.1 GO:0018298 protein-chromophore linkage(GO:0018298)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0098536 deuterosome(GO:0098536)
0.0 0.1 GO:0032593 insulin-responsive compartment(GO:0032593)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 0.1 GO:0031705 bombesin receptor binding(GO:0031705)
0.0 0.1 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.0 0.1 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.1 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME OPSINS Genes involved in Opsins