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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for DLX5

Z-value: 0.55

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Transcription factors associated with DLX5

Gene Symbol Gene ID Gene Info
DLX5
ENSG00000105880.4 distal-less homeobox 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DLX5hg19_v2_chr7_-_96654133_96654409-0.473.5e-01Click!

Activity profile of DLX5 motif

Sorted Z-values of DLX5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_74853897 0.50 ENST00000296028.3
PPBP
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
chr19_+_36239576 0.46 ENST00000587751.1
LIN37
lin-37 homolog (C. elegans)
chr11_+_115498761 0.43 ENST00000424313.2
AP000997.1
AP000997.1
chrX_+_100224676 0.21 ENST00000450049.2
ARL13A
ADP-ribosylation factor-like 13A
chr5_+_142286887 0.20 ENST00000451259.1
ARHGAP26
Rho GTPase activating protein 26
chr17_+_36508826 0.19 ENST00000580660.1
SOCS7
suppressor of cytokine signaling 7
chr17_-_47786375 0.18 ENST00000511657.1
SLC35B1
solute carrier family 35, member B1
chr14_-_24711764 0.17 ENST00000557921.1
ENST00000558476.1
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr14_-_24711470 0.15 ENST00000559969.1
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr4_-_7069760 0.13 ENST00000264954.4
GRPEL1
GrpE-like 1, mitochondrial (E. coli)
chr14_-_24711865 0.13 ENST00000399423.4
ENST00000267415.7
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr6_-_78173490 0.12 ENST00000369947.2
HTR1B
5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
chr11_-_102651343 0.11 ENST00000279441.4
ENST00000539681.1
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr14_-_24711806 0.11 ENST00000540705.1
ENST00000538777.1
ENST00000558566.1
ENST00000559019.1
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr2_+_228736335 0.11 ENST00000440997.1
ENST00000545118.1
DAW1
dynein assembly factor with WDR repeat domains 1
chr6_+_130339710 0.11 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr6_+_123038689 0.11 ENST00000354275.2
ENST00000368446.1
PKIB
protein kinase (cAMP-dependent, catalytic) inhibitor beta
chr8_-_49533521 0.11 ENST00000523038.1
RP11-567J20.1
RP11-567J20.1
chr13_+_36050881 0.10 ENST00000537702.1
NBEA
neurobeachin
chr6_-_33256664 0.10 ENST00000444176.1
WDR46
WD repeat domain 46
chr8_-_22526597 0.10 ENST00000519513.1
ENST00000276416.6
ENST00000520292.1
ENST00000522268.1
BIN3
bridging integrator 3
chr10_-_99205607 0.10 ENST00000477692.2
ENST00000485122.2
ENST00000370886.5
ENST00000370885.4
ENST00000370902.3
ENST00000370884.5
EXOSC1
exosome component 1
chr11_+_73498973 0.10 ENST00000537007.1
MRPL48
mitochondrial ribosomal protein L48
chr8_+_32579321 0.09 ENST00000522402.1
NRG1
neuregulin 1
chr12_+_64798826 0.09 ENST00000540203.1
XPOT
exportin, tRNA
chr14_-_68283291 0.09 ENST00000555452.1
ENST00000347230.4
ZFYVE26
zinc finger, FYVE domain containing 26
chr3_+_186560476 0.08 ENST00000320741.2
ENST00000444204.2
ADIPOQ
adiponectin, C1Q and collagen domain containing
chr10_-_128110441 0.08 ENST00000456514.1
LINC00601
long intergenic non-protein coding RNA 601
chr16_+_58010339 0.08 ENST00000290871.5
ENST00000441824.2
TEPP
testis, prostate and placenta expressed
chr1_-_78444776 0.08 ENST00000370767.1
ENST00000421641.1
FUBP1
far upstream element (FUSE) binding protein 1
chr5_-_20575959 0.08 ENST00000507958.1
CDH18
cadherin 18, type 2
chr3_-_105587879 0.08 ENST00000264122.4
ENST00000403724.1
ENST00000405772.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr16_+_24621546 0.07 ENST00000566108.1
CTD-2540M10.1
CTD-2540M10.1
chr4_+_169575875 0.07 ENST00000503457.1
PALLD
palladin, cytoskeletal associated protein
chr1_-_242612726 0.07 ENST00000459864.1
PLD5
phospholipase D family, member 5
chr8_-_10512569 0.07 ENST00000382483.3
RP1L1
retinitis pigmentosa 1-like 1
chr8_+_32579341 0.07 ENST00000519240.1
ENST00000539990.1
NRG1
neuregulin 1
chr11_-_33913708 0.07 ENST00000257818.2
LMO2
LIM domain only 2 (rhombotin-like 1)
chr17_-_47785504 0.07 ENST00000514907.1
ENST00000503334.1
ENST00000508520.1
SLC35B1
solute carrier family 35, member B1
chr3_+_186288454 0.07 ENST00000265028.3
DNAJB11
DnaJ (Hsp40) homolog, subfamily B, member 11
chrX_-_16887963 0.07 ENST00000380084.4
RBBP7
retinoblastoma binding protein 7
chr2_+_228736321 0.06 ENST00000309931.2
DAW1
dynein assembly factor with WDR repeat domains 1
chr7_+_99717230 0.06 ENST00000262932.3
CNPY4
canopy FGF signaling regulator 4
chr4_-_89442940 0.06 ENST00000527353.1
PIGY
phosphatidylinositol glycan anchor biosynthesis, class Y
chr1_-_78444738 0.06 ENST00000436586.2
ENST00000370768.2
FUBP1
far upstream element (FUSE) binding protein 1
chr1_-_198906528 0.06 ENST00000432296.1
MIR181A1HG
MIR181A1 host gene (non-protein coding)
chr8_+_32579271 0.06 ENST00000518084.1
NRG1
neuregulin 1
chr2_-_220118631 0.06 ENST00000248437.4
TUBA4A
tubulin, alpha 4a
chr12_-_57039739 0.06 ENST00000552959.1
ENST00000551020.1
ENST00000553007.2
ENST00000552919.1
ENST00000552104.1
ENST00000262030.3
ATP5B
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr3_+_186560462 0.06 ENST00000412955.2
ADIPOQ
adiponectin, C1Q and collagen domain containing
chr11_+_76092353 0.06 ENST00000530460.1
ENST00000321844.4
RP11-111M22.2
Homo sapiens putative uncharacterized protein FLJ37770-like (LOC100506127), mRNA.
chr2_+_30369807 0.05 ENST00000379520.3
ENST00000379519.3
ENST00000261353.4
YPEL5
yippee-like 5 (Drosophila)
chr17_-_37009882 0.05 ENST00000378096.3
ENST00000394332.1
ENST00000394333.1
ENST00000577407.1
ENST00000479035.2
RPL23
ribosomal protein L23
chr10_+_99205894 0.05 ENST00000370854.3
ENST00000393760.1
ENST00000414567.1
ENST00000370846.4
ZDHHC16
zinc finger, DHHC-type containing 16
chr19_+_36606354 0.05 ENST00000589996.1
ENST00000591296.1
TBCB
tubulin folding cofactor B
chr9_+_34646651 0.05 ENST00000378842.3
GALT
galactose-1-phosphate uridylyltransferase
chr15_+_89631647 0.05 ENST00000569550.1
ENST00000565066.1
ENST00000565973.1
ABHD2
abhydrolase domain containing 2
chr9_+_34646624 0.05 ENST00000450095.2
ENST00000556278.1
GALT
GALT
galactose-1-phosphate uridylyltransferase
Uncharacterized protein
chr22_-_30960876 0.04 ENST00000401975.1
ENST00000428682.1
ENST00000423299.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr2_+_228735763 0.04 ENST00000373666.2
DAW1
dynein assembly factor with WDR repeat domains 1
chr15_+_89164520 0.04 ENST00000332810.3
AEN
apoptosis enhancing nuclease
chr7_-_14028488 0.04 ENST00000405358.4
ETV1
ets variant 1
chr12_+_7014126 0.04 ENST00000415834.1
ENST00000436789.1
LRRC23
leucine rich repeat containing 23
chr19_+_58570605 0.04 ENST00000359978.6
ENST00000401053.4
ENST00000439855.2
ENST00000313434.5
ENST00000511556.1
ENST00000506786.1
ZNF135
zinc finger protein 135
chr1_+_160160346 0.04 ENST00000368078.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr5_-_58571935 0.04 ENST00000503258.1
PDE4D
phosphodiesterase 4D, cAMP-specific
chr3_-_180397256 0.04 ENST00000442201.2
CCDC39
coiled-coil domain containing 39
chr1_+_160160283 0.04 ENST00000368079.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr1_-_114447412 0.04 ENST00000369567.1
ENST00000369566.3
AP4B1
adaptor-related protein complex 4, beta 1 subunit
chr2_-_44550441 0.04 ENST00000420756.1
ENST00000444696.1
PREPL
prolyl endopeptidase-like
chr6_-_38670897 0.04 ENST00000373365.4
GLO1
glyoxalase I
chr10_+_99205959 0.04 ENST00000352634.4
ENST00000353979.3
ENST00000370842.2
ENST00000345745.5
ZDHHC16
zinc finger, DHHC-type containing 16
chr13_-_36050819 0.04 ENST00000379919.4
MAB21L1
mab-21-like 1 (C. elegans)
chr4_-_69111401 0.04 ENST00000332644.5
TMPRSS11B
transmembrane protease, serine 11B
chr11_+_73498898 0.04 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
MRPL48
mitochondrial ribosomal protein L48
chr17_+_59489112 0.04 ENST00000335108.2
C17orf82
chromosome 17 open reading frame 82
chr9_+_116225999 0.04 ENST00000317613.6
RGS3
regulator of G-protein signaling 3
chr3_+_11178779 0.03 ENST00000438284.2
HRH1
histamine receptor H1
chr6_-_112194484 0.03 ENST00000518295.1
ENST00000484067.2
ENST00000229470.5
ENST00000356013.2
ENST00000368678.4
ENST00000523238.1
ENST00000354650.3
FYN
FYN oncogene related to SRC, FGR, YES
chr1_-_28969517 0.03 ENST00000263974.4
ENST00000373824.4
TAF12
TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
chrX_+_100645812 0.03 ENST00000427805.2
ENST00000553110.3
ENST00000392994.3
ENST00000409338.1
ENST00000409170.3
RPL36A
RPL36A-HNRNPH2
ribosomal protein L36a
RPL36A-HNRNPH2 readthrough
chr3_-_105588231 0.03 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
CBLB
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr19_-_14785622 0.03 ENST00000443157.2
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr19_-_14785698 0.03 ENST00000344373.4
ENST00000595472.1
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr12_+_54378923 0.03 ENST00000303460.4
HOXC10
homeobox C10
chr12_-_95774672 0.02 ENST00000549961.1
RP11-167N24.6
Uncharacterized protein
chr2_-_172290482 0.02 ENST00000442541.1
ENST00000392599.2
ENST00000375258.4
METTL8
methyltransferase like 8
chr17_+_72931876 0.02 ENST00000328801.4
OTOP3
otopetrin 3
chr19_-_14785674 0.02 ENST00000253673.5
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr11_-_71823715 0.02 ENST00000545944.1
ENST00000502597.2
ANAPC15
anaphase promoting complex subunit 15
chr4_-_66536057 0.02 ENST00000273854.3
EPHA5
EPH receptor A5
chr8_-_124553437 0.02 ENST00000517956.1
ENST00000443022.2
FBXO32
F-box protein 32
chr1_+_61547405 0.02 ENST00000371189.4
NFIA
nuclear factor I/A
chr2_+_30369859 0.02 ENST00000402003.3
YPEL5
yippee-like 5 (Drosophila)
chr18_+_55888767 0.02 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr2_-_183387283 0.02 ENST00000435564.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr18_-_53255379 0.02 ENST00000565908.2
TCF4
transcription factor 4
chr11_-_71823266 0.02 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
ANAPC15
anaphase promoting complex subunit 15
chr10_-_56561022 0.02 ENST00000373965.2
ENST00000414778.1
ENST00000395438.1
ENST00000409834.1
ENST00000395445.1
ENST00000395446.1
ENST00000395442.1
ENST00000395440.1
ENST00000395432.2
ENST00000361849.3
ENST00000395433.1
ENST00000320301.6
ENST00000395430.1
ENST00000437009.1
PCDH15
protocadherin-related 15
chr12_+_52695617 0.02 ENST00000293525.5
KRT86
keratin 86
chr10_-_97200772 0.02 ENST00000371241.1
ENST00000354106.3
ENST00000371239.1
ENST00000361941.3
ENST00000277982.5
ENST00000371245.3
SORBS1
sorbin and SH3 domain containing 1
chr7_+_100770328 0.02 ENST00000223095.4
ENST00000445463.2
SERPINE1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
chr15_+_41913690 0.01 ENST00000563576.1
MGA
MGA, MAX dimerization protein
chr1_-_150669604 0.01 ENST00000427665.1
ENST00000540514.1
GOLPH3L
golgi phosphoprotein 3-like
chr4_-_66536196 0.01 ENST00000511294.1
EPHA5
EPH receptor A5
chr12_-_50616382 0.01 ENST00000552783.1
LIMA1
LIM domain and actin binding 1
chr1_-_201140673 0.01 ENST00000367333.2
TMEM9
transmembrane protein 9
chr1_-_151762900 0.01 ENST00000440583.2
TDRKH
tudor and KH domain containing
chr2_+_105050794 0.01 ENST00000429464.1
ENST00000414442.1
ENST00000447380.1
AC013402.2
long intergenic non-protein coding RNA 1102
chr1_+_54569968 0.01 ENST00000391366.1
AL161915.1
Uncharacterized protein
chr1_-_23670813 0.01 ENST00000374612.1
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr1_+_202317855 0.01 ENST00000356764.2
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr5_+_110559312 0.00 ENST00000508074.1
CAMK4
calcium/calmodulin-dependent protein kinase IV
chr17_+_28268623 0.00 ENST00000394835.3
ENST00000320856.5
ENST00000394832.2
ENST00000378738.3
EFCAB5
EF-hand calcium binding domain 5
chr4_-_143767428 0.00 ENST00000513000.1
ENST00000509777.1
ENST00000503927.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr4_+_77356248 0.00 ENST00000296043.6
SHROOM3
shroom family member 3
chr19_-_19302931 0.00 ENST00000444486.3
ENST00000514819.3
ENST00000585679.1
ENST00000162023.5
MEF2BNB-MEF2B
MEF2BNB
MEF2B
MEF2BNB-MEF2B readthrough
MEF2B neighbor
myocyte enhancer factor 2B
chr12_+_7014064 0.00 ENST00000443597.2
LRRC23
leucine rich repeat containing 23
chr2_-_183387430 0.00 ENST00000410103.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent

Network of associatons between targets according to the STRING database.

First level regulatory network of DLX5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0010836 negative regulation of protein ADP-ribosylation(GO:0010836)
0.1 0.3 GO:0015785 UDP-galactose transport(GO:0015785) UDP-galactose transmembrane transport(GO:0072334)
0.0 0.1 GO:0097018 renal albumin absorption(GO:0097018) regulation of renal albumin absorption(GO:2000532) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.0 0.1 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.0 0.1 GO:0014839 myoblast migration involved in skeletal muscle regeneration(GO:0014839)
0.0 0.1 GO:0006258 UDP-glucose catabolic process(GO:0006258)
0.0 0.2 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129)
0.0 0.5 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.0 0.2 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0010370 perinucleolar chromocenter(GO:0010370)
0.0 0.1 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 0.1 GO:0014802 terminal cisterna(GO:0014802)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.0 0.5 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.2 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.1 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.1 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.1 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.5 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.5 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends