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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for DLX4_HOXD8
Z-value: 0.64
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Transcription factors associated with DLX4_HOXD8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXD8 | hg19_v2_chr2_+_176995011_176995085 | -0.42 | 4.1e-01 | Click! |
| DLX4 | hg19_v2_chr17_+_48046671_48046697 | -0.42 | 4.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_-_66864806 Show fit | 0.51 |
ENST00000566336.1
ENST00000394074.2 ENST00000563185.2 ENST00000359087.4 ENST00000379463.2 ENST00000565535.1 ENST00000290810.3 |
NEDD8 activating enzyme E1 subunit 1 |
|
| chr7_-_35013217 Show fit | 0.47 |
ENST00000446375.1
|
dpy-19-like 1 (C. elegans) |
|
| chr1_+_152784447 Show fit | 0.41 |
ENST00000360090.3
|
late cornified envelope 1B |
|
| chr10_+_6779326 Show fit | 0.35 |
ENST00000417112.1
|
RP11-554I8.2 |
|
| chr1_-_168464875 Show fit | 0.33 |
ENST00000422253.1
|
RP5-968D22.3 |
|
| chr6_+_63921399 Show fit | 0.33 |
ENST00000356170.3
|
FK506 binding protein 1C |
|
| chr11_-_104817919 Show fit | 0.33 |
ENST00000533252.1
|
caspase 4, apoptosis-related cysteine peptidase |
|
| chr4_-_137842536 Show fit | 0.32 |
ENST00000512039.1
|
RP11-138I17.1 |
|
| chr10_-_128110441 Show fit | 0.31 |
ENST00000456514.1
|
long intergenic non-protein coding RNA 601 |
|
| chr19_-_57678811 Show fit | 0.30 |
ENST00000554048.2
|
double homeobox A |
Network of associatons between targets according to the STRING database.
First level regulatory network of DLX4_HOXD8
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 0.1 | 0.6 | GO:0018406 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
| 0.0 | 0.5 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 0.0 | 0.5 | GO:0009437 | carnitine metabolic process(GO:0009437) |
| 0.1 | 0.4 | GO:1902173 | negative regulation of keratinocyte apoptotic process(GO:1902173) |
| 0.0 | 0.4 | GO:1903265 | positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265) |
| 0.1 | 0.3 | GO:2001106 | regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106) |
| 0.0 | 0.3 | GO:0031666 | positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666) |
| 0.0 | 0.3 | GO:1903385 | regulation of homophilic cell adhesion(GO:1903385) |
| 0.0 | 0.3 | GO:0097338 | response to clozapine(GO:0097338) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.1 | 0.4 | GO:0097169 | AIM2 inflammasome complex(GO:0097169) |
| 0.0 | 0.4 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 0.4 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 0.3 | GO:0061617 | MICOS complex(GO:0061617) |
| 0.0 | 0.2 | GO:0030061 | mitochondrial crista(GO:0030061) |
| 0.0 | 0.2 | GO:0031429 | box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) |
| 0.0 | 0.2 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.0 | 0.2 | GO:0000439 | core TFIIH complex(GO:0000439) |
| 0.0 | 0.2 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
| 0.2 | 0.6 | GO:0019781 | NEDD8 activating enzyme activity(GO:0019781) |
| 0.0 | 0.6 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.0 | 0.4 | GO:0070330 | aromatase activity(GO:0070330) |
| 0.0 | 0.4 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.0 | 0.4 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.0 | 0.4 | GO:0005527 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.1 | 0.3 | GO:1990698 | palmitoleoyltransferase activity(GO:1990698) |
| 0.1 | 0.3 | GO:0004031 | aldehyde oxidase activity(GO:0004031) |
| 0.0 | 0.3 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.0 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.0 | 0.5 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 0.4 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 0.3 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.0 | 0.2 | REACTOME ACYL CHAIN REMODELLING OF PG | Genes involved in Acyl chain remodelling of PG |
| 0.0 | 0.2 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.0 | 0.2 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.0 | 0.0 | REACTOME REGULATION OF APOPTOSIS | Genes involved in Regulation of Apoptosis |