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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for DDIT3

Z-value: 0.75

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Transcription factors associated with DDIT3

Gene Symbol Gene ID Gene Info
ENSG00000175197.6 DNA damage inducible transcript 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DDIT3hg19_v2_chr12_-_57914275_579143040.853.2e-02Click!

Activity profile of DDIT3 motif

Sorted Z-values of DDIT3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_77967433 0.78 ENST00000571872.1
TBC1 domain family, member 16
chr6_+_144606817 0.64 ENST00000433557.1
utrophin
chr1_+_149804218 0.37 ENST00000610125.1
histone cluster 2, H4a
chr14_+_64565442 0.35 ENST00000553308.1
spectrin repeat containing, nuclear envelope 2
chr10_+_86004802 0.31 ENST00000359452.4
ENST00000358110.5
ENST00000372092.3
retinal G protein coupled receptor
chr10_-_116444371 0.30 ENST00000533213.2
ENST00000369252.4
actin binding LIM protein 1
chr4_+_141178440 0.29 ENST00000394205.3
short coiled-coil protein
chr19_+_41497178 0.28 ENST00000324071.4
cytochrome P450, family 2, subfamily B, polypeptide 6
chr2_-_63815628 0.26 ENST00000409562.3
WD repeat containing planar cell polarity effector
chr7_-_56101826 0.26 ENST00000421626.1
phosphoserine phosphatase
chr1_+_174844645 0.26 ENST00000486220.1
RAB GTPase activating protein 1-like
chr6_-_86353510 0.25 ENST00000444272.1
synaptotagmin binding, cytoplasmic RNA interacting protein
chr1_-_67519782 0.25 ENST00000235345.5
solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
chr15_+_85923856 0.22 ENST00000560302.1
ENST00000394518.2
ENST00000361243.2
ENST00000560256.1
A kinase (PRKA) anchor protein 13
chr1_-_149832704 0.22 ENST00000392933.1
ENST00000369157.2
ENST00000392932.4
histone cluster 2, H4b
chr20_+_5987890 0.22 ENST00000378868.4
cardiolipin synthase 1
chr7_+_90338547 0.20 ENST00000446790.1
cyclin-dependent kinase 14
chr4_+_157997273 0.20 ENST00000541722.1
ENST00000512619.1
glycine receptor, beta
chr14_-_23446003 0.18 ENST00000553911.1
ajuba LIM protein
chr12_-_25102252 0.17 ENST00000261192.7
branched chain amino-acid transaminase 1, cytosolic
chr9_+_80912059 0.17 ENST00000347159.2
ENST00000376588.3
phosphoserine aminotransferase 1
chr4_+_6784358 0.17 ENST00000508423.1
KIAA0232
chr12_-_63328817 0.17 ENST00000228705.6
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr3_-_45883558 0.17 ENST00000445698.1
ENST00000296135.6
leucine zipper transcription factor-like 1
chr15_-_83837983 0.17 ENST00000562702.1
Hepatoma-derived growth factor-related protein 3
chr15_-_64126084 0.16 ENST00000560316.1
ENST00000443617.2
ENST00000560462.1
ENST00000558532.1
ENST00000561400.1
HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
chr15_+_85923797 0.16 ENST00000559362.1
A kinase (PRKA) anchor protein 13
chr5_+_112074029 0.16 ENST00000512211.2
adenomatous polyposis coli
chr19_-_6604094 0.16 ENST00000597430.2
CD70 molecule
chr14_+_62462541 0.16 ENST00000430451.2
synaptotagmin XVI
chr6_+_80341000 0.15 ENST00000369838.4
SH3 domain binding glutamic acid-rich protein like 2
chr16_+_56970567 0.15 ENST00000563911.1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr12_+_64798826 0.15 ENST00000540203.1
exportin, tRNA
chr4_-_99578789 0.15 ENST00000511651.1
ENST00000505184.1
tetraspanin 5
chr18_-_55288973 0.15 ENST00000423481.2
ENST00000587194.1
ENST00000591599.1
ENST00000588661.1
asparaginyl-tRNA synthetase
chr3_+_38017264 0.15 ENST00000436654.1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr7_-_130597935 0.14 ENST00000447307.1
ENST00000418546.1
microRNA 29a
chr12_+_32638897 0.14 ENST00000531134.1
FYVE, RhoGEF and PH domain containing 4
chr2_+_63816295 0.13 ENST00000539945.1
ENST00000544381.1
malate dehydrogenase 1, NAD (soluble)
chr2_+_63816126 0.13 ENST00000454035.1
malate dehydrogenase 1, NAD (soluble)
chr2_+_63816087 0.13 ENST00000409908.1
ENST00000442225.1
ENST00000409476.1
ENST00000436321.1
malate dehydrogenase 1, NAD (soluble)
chr3_+_136676707 0.12 ENST00000329582.4
interleukin 20 receptor beta
chr12_-_25101920 0.12 ENST00000539780.1
ENST00000546285.1
ENST00000342945.5
branched chain amino-acid transaminase 1, cytosolic
chr3_+_136676851 0.12 ENST00000309741.5
interleukin 20 receptor beta
chr5_-_137878887 0.12 ENST00000507939.1
ENST00000572514.1
ENST00000499810.2
ENST00000360541.5
eukaryotic translation termination factor 1
chr14_+_32798547 0.12 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
A kinase (PRKA) anchor protein 6
chr10_-_92681033 0.11 ENST00000371697.3
ankyrin repeat domain 1 (cardiac muscle)
chr11_-_8680383 0.11 ENST00000299550.6
tripartite motif containing 66
chr2_-_208030886 0.10 ENST00000426163.1
Kruppel-like factor 7 (ubiquitous)
chr14_-_23446021 0.10 ENST00000553592.1
ajuba LIM protein
chr2_-_43453734 0.10 ENST00000282388.3
ZFP36 ring finger protein-like 2
chr16_+_56965960 0.10 ENST00000439977.2
ENST00000344114.4
ENST00000300302.5
ENST00000379792.2
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr11_+_47279155 0.10 ENST00000444396.1
ENST00000457932.1
ENST00000412937.1
nuclear receptor subfamily 1, group H, member 3
chr7_-_130598059 0.09 ENST00000432045.2
microRNA 29a
chr4_+_6784401 0.09 ENST00000425103.1
ENST00000307659.5
KIAA0232
chr5_+_72143988 0.09 ENST00000506351.2
transportin 1
chr11_+_34073195 0.09 ENST00000341394.4
cell cycle associated protein 1
chr2_-_101925055 0.09 ENST00000295317.3
ring finger protein 149
chrX_-_138724677 0.09 ENST00000370573.4
ENST00000338585.6
ENST00000370576.4
MCF.2 cell line derived transforming sequence
chr11_-_10315741 0.09 ENST00000256190.8
SET binding factor 2
chr2_+_63816269 0.08 ENST00000432309.1
malate dehydrogenase 1, NAD (soluble)
chr10_+_12391481 0.08 ENST00000378847.3
calcium/calmodulin-dependent protein kinase ID
chr12_+_50144381 0.08 ENST00000552370.1
transmembrane BAX inhibitor motif containing 6
chr4_-_184243561 0.08 ENST00000514470.1
ENST00000541814.1
claudin 24
chr9_-_124991124 0.08 ENST00000394319.4
ENST00000340587.3
LIM homeobox 6
chr11_-_104972158 0.08 ENST00000598974.1
ENST00000593315.1
ENST00000594519.1
ENST00000415981.2
ENST00000525374.1
ENST00000375707.1
caspase 1, apoptosis-related cysteine peptidase
caspase recruitment domain family, member 16
caspase recruitment domain family, member 17
chr8_+_26435915 0.07 ENST00000523027.1
dihydropyrimidinase-like 2
chr12_-_122017542 0.07 ENST00000446152.2
lysine (K)-specific demethylase 2B
chr14_-_92413727 0.07 ENST00000267620.10
fibulin 5
chr14_-_74226961 0.07 ENST00000286523.5
ENST00000435371.1
ELM2 and Myb/SANT-like domain containing 1
chr11_+_62495541 0.07 ENST00000530625.1
ENST00000513247.2
tetratricopeptide repeat domain 9C
chr11_-_33913708 0.07 ENST00000257818.2
LIM domain only 2 (rhombotin-like 1)
chr1_-_114447412 0.07 ENST00000369567.1
ENST00000369566.3
adaptor-related protein complex 4, beta 1 subunit
chr20_-_60294804 0.06 ENST00000317652.1
Uncharacterized protein
chr21_-_46334186 0.06 ENST00000522931.1
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr1_+_111770232 0.06 ENST00000369744.2
chitinase 3-like 2
chr7_+_99006232 0.06 ENST00000403633.2
BUD31 homolog (S. cerevisiae)
chr3_+_130569429 0.06 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
ATPase, Ca++ transporting, type 2C, member 1
chr3_+_15643476 0.06 ENST00000436193.1
ENST00000383778.4
biotinidase
chr2_-_161350305 0.06 ENST00000348849.3
RNA binding motif, single stranded interacting protein 1
chr3_+_44840679 0.05 ENST00000425755.1
kinesin family member 15
chr1_-_152196669 0.05 ENST00000368801.2
hornerin
chr8_+_27629459 0.05 ENST00000523566.1
establishment of sister chromatid cohesion N-acetyltransferase 2
chr9_+_110045537 0.05 ENST00000358015.3
RAD23 homolog B (S. cerevisiae)
chr14_+_32798462 0.05 ENST00000280979.4
A kinase (PRKA) anchor protein 6
chr3_-_148939835 0.05 ENST00000264613.6
ceruloplasmin (ferroxidase)
chr5_+_145583156 0.05 ENST00000265271.5
RNA binding motif protein 27
chr17_-_46691990 0.04 ENST00000576562.1
homeobox B8
chr17_-_30228678 0.04 ENST00000261708.4
UTP6, small subunit (SSU) processome component, homolog (yeast)
chr20_+_54987168 0.04 ENST00000360314.3
Cas scaffolding protein family member 4
chr9_-_95055956 0.04 ENST00000375629.3
ENST00000447699.2
ENST00000375643.3
ENST00000395554.3
isoleucyl-tRNA synthetase
chr3_+_186330712 0.04 ENST00000411641.2
ENST00000273784.5
alpha-2-HS-glycoprotein
chr20_+_24929866 0.04 ENST00000480798.1
ENST00000376835.2
cystatin F (leukocystatin)
chr19_-_49258606 0.04 ENST00000310160.3
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr5_+_145583107 0.04 ENST00000506502.1
RNA binding motif protein 27
chr11_+_47279504 0.04 ENST00000441012.2
ENST00000437276.1
ENST00000436029.1
ENST00000467728.1
ENST00000405853.3
nuclear receptor subfamily 1, group H, member 3
chr16_-_18908196 0.04 ENST00000565324.1
ENST00000561947.1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr11_+_34073269 0.04 ENST00000389645.3
cell cycle associated protein 1
chr17_-_2117600 0.03 ENST00000572369.1
SMG6 nonsense mediated mRNA decay factor
chr2_-_208030647 0.03 ENST00000309446.6
Kruppel-like factor 7 (ubiquitous)
chr6_+_151187074 0.03 ENST00000367308.4
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr13_-_45915221 0.03 ENST00000309246.5
ENST00000379060.4
ENST00000379055.1
ENST00000527226.1
ENST00000379056.1
tumor protein, translationally-controlled 1
chr12_-_12491608 0.03 ENST00000545735.1
MANSC domain containing 1
chr9_-_95056010 0.03 ENST00000443024.2
isoleucyl-tRNA synthetase
chr3_+_12392971 0.03 ENST00000287820.6
peroxisome proliferator-activated receptor gamma
chr8_-_18744528 0.03 ENST00000523619.1
pleckstrin and Sec7 domain containing 3
chr13_-_24007815 0.03 ENST00000382298.3
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr4_+_111397216 0.03 ENST00000265162.5
glutamyl aminopeptidase (aminopeptidase A)
chr17_-_34257771 0.02 ENST00000394529.3
ENST00000293273.6
RAD52 motif 1
chr7_-_99006443 0.02 ENST00000350498.3
PDGFA associated protein 1
chr1_+_114447763 0.02 ENST00000369563.3
DNA cross-link repair 1B
chr22_+_31518938 0.02 ENST00000412985.1
ENST00000331075.5
ENST00000412277.2
ENST00000420017.1
ENST00000400294.2
ENST00000405300.1
ENST00000404390.3
inositol polyphosphate-5-phosphatase J
chr1_+_111770278 0.02 ENST00000369748.4
chitinase 3-like 2
chr9_-_77502636 0.02 ENST00000449912.2
transient receptor potential cation channel, subfamily M, member 6
chr1_-_207143802 0.02 ENST00000324852.4
ENST00000400962.3
Fc receptor, IgA, IgM, high affinity
chr1_+_150954493 0.02 ENST00000368947.4
annexin A9
chr19_+_33865218 0.02 ENST00000585933.2
CCAAT/enhancer binding protein (C/EBP), gamma
chr19_-_35992780 0.02 ENST00000593342.1
ENST00000601650.1
ENST00000408915.2
dermokine
chr2_+_68872954 0.02 ENST00000394342.2
prokineticin receptor 1
chr10_+_103986085 0.02 ENST00000370005.3
ELOVL fatty acid elongase 3
chr2_+_227700652 0.02 ENST00000341329.3
ENST00000392062.2
ENST00000437454.1
ENST00000443477.1
ENST00000423616.1
ENST00000448992.1
rhomboid domain containing 1
chr6_+_31895287 0.02 ENST00000447952.2
complement component 2
chr12_+_57857475 0.01 ENST00000528467.1
GLI family zinc finger 1
chr10_+_60028818 0.01 ENST00000333926.5
CDGSH iron sulfur domain 1
chr5_-_131630931 0.01 ENST00000431054.1
prolyl 4-hydroxylase, alpha polypeptide II
chr9_+_112542591 0.01 ENST00000483909.1
ENST00000314527.4
ENST00000413420.1
ENST00000302798.7
ENST00000555236.1
ENST00000510514.5
paralemmin 2
PALM2-AKAP2 readthrough
A kinase (PRKA) anchor protein 2
chr13_+_24844979 0.01 ENST00000454083.1
spermatogenesis associated 13
chrX_-_138724994 0.00 ENST00000536274.1
MCF.2 cell line derived transforming sequence
chr1_+_90308981 0.00 ENST00000527156.1
leucine rich repeat containing 8 family, member D
chr10_+_102756800 0.00 ENST00000370223.3
leucine zipper, putative tumor suppressor 2
chr10_-_13523073 0.00 ENST00000440282.1
BEN domain containing 7
chr19_+_12917364 0.00 ENST00000221486.4
ribonuclease H2, subunit A
chr11_+_62495997 0.00 ENST00000316461.4
tetratricopeptide repeat domain 9C

Network of associatons between targets according to the STRING database.

First level regulatory network of DDIT3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.1 0.2 GO:0001808 negative regulation of type IV hypersensitivity(GO:0001808)
0.1 0.2 GO:1903568 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.0 0.3 GO:0009099 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.0 0.4 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.0 0.3 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.2 GO:0016476 regulation of embryonic cell shape(GO:0016476)
0.0 0.1 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.0 0.6 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.2 GO:0097112 gamma-aminobutyric acid receptor clustering(GO:0097112)
0.0 0.5 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.2 GO:0042816 vitamin B6 metabolic process(GO:0042816)
0.0 0.2 GO:0097068 response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386)
0.0 0.3 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.2 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.0 0.1 GO:0090341 negative regulation of secretion of lysosomal enzymes(GO:0090341)
0.0 0.3 GO:0042738 exogenous drug catabolic process(GO:0042738)
0.0 0.3 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.2 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.1 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.0 0.2 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
0.0 0.1 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.0 0.3 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.3 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.1 GO:0021993 initiation of neural tube closure(GO:0021993)
0.0 0.8 GO:0001919 regulation of receptor recycling(GO:0001919)
0.0 0.1 GO:1904721 negative regulation of mRNA cleavage(GO:0031438) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.0 0.2 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.0 0.1 GO:0060267 positive regulation of respiratory burst(GO:0060267)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0016935 glycine-gated chloride channel complex(GO:0016935)
0.0 0.2 GO:1990037 Lewy body core(GO:1990037)
0.0 0.2 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.6 GO:0070938 contractile ring(GO:0070938)
0.0 0.3 GO:0097452 GAIT complex(GO:0097452)
0.0 0.4 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.1 GO:0005873 plus-end kinesin complex(GO:0005873)
0.0 0.1 GO:0097179 protease inhibitor complex(GO:0097179)
0.0 0.2 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0047860 diiodophenylpyruvate reductase activity(GO:0047860)
0.1 0.2 GO:0043337 cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572) CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity(GO:0043337)
0.0 0.3 GO:0052656 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.3 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.3 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.2 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.1 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0 0.2 GO:0016933 inhibitory extracellular ligand-gated ion channel activity(GO:0005237) extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.4 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.2 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 0.1 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.0 0.6 GO:0017166 vinculin binding(GO:0017166)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.1 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.3 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.1 GO:0047708 biotinidase activity(GO:0047708)
0.0 0.1 GO:0032810 sterol response element binding(GO:0032810)
0.0 0.3 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.1 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 REACTOME OPSINS Genes involved in Opsins
0.0 0.3 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 0.4 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.6 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends