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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for DBP
Z-value: 1.02
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Transcription factors associated with DBP
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| DBP | hg19_v2_chr19_-_49140692_49140709 | 0.61 | 2.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr21_+_17791648 Show fit | 1.14 |
ENST00000602892.1
ENST00000418813.2 ENST00000435697.1 |
long intergenic non-protein coding RNA 478 |
|
| chr4_-_23891693 Show fit | 0.81 |
ENST00000264867.2
|
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
|
| chr17_+_26833250 Show fit | 0.71 |
ENST00000577936.1
ENST00000579795.1 |
forkhead box N1 |
|
| chr8_-_72268721 Show fit | 0.40 |
ENST00000419131.1
ENST00000388743.2 |
eyes absent homolog 1 (Drosophila) |
|
| chr13_+_97874574 Show fit | 0.39 |
ENST00000343600.4
ENST00000345429.6 ENST00000376673.3 |
muscleblind-like splicing regulator 2 |
|
| chr16_-_79634595 Show fit | 0.38 |
ENST00000326043.4
ENST00000393350.1 |
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog |
|
| chr2_-_164592497 Show fit | 0.38 |
ENST00000333129.3
ENST00000409634.1 |
fidgetin |
|
| chr1_-_108231101 Show fit | 0.38 |
ENST00000544443.1
ENST00000415432.2 |
vav 3 guanine nucleotide exchange factor |
|
| chr17_-_8263538 Show fit | 0.38 |
ENST00000535173.1
|
HCG1985372; Uncharacterized protein; cDNA FLJ37541 fis, clone BRCAN2026340 |
|
| chr8_+_86999516 Show fit | 0.38 |
ENST00000521564.1
|
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of DBP
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 0.9 | GO:0014878 | response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878) positive regulation of mitochondrial DNA metabolic process(GO:1901860) response to methionine(GO:1904640) |
| 0.2 | 0.7 | GO:0097534 | lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535) regulation of positive thymic T cell selection(GO:1902232) |
| 0.0 | 0.7 | GO:0090383 | phagosome acidification(GO:0090383) |
| 0.1 | 0.6 | GO:0072709 | cellular response to sorbitol(GO:0072709) |
| 0.0 | 0.6 | GO:0034465 | response to carbon monoxide(GO:0034465) |
| 0.1 | 0.5 | GO:2000980 | regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980) |
| 0.0 | 0.4 | GO:0002159 | desmosome assembly(GO:0002159) |
| 0.0 | 0.4 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
| 0.0 | 0.4 | GO:0045586 | regulation of gamma-delta T cell differentiation(GO:0045586) |
| 0.0 | 0.4 | GO:0090179 | planar cell polarity pathway involved in neural tube closure(GO:0090179) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.0 | 0.8 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.0 | 0.7 | GO:0016471 | vacuolar proton-transporting V-type ATPase complex(GO:0016471) |
| 0.0 | 0.5 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 0.3 | GO:0030130 | clathrin coat of trans-Golgi network vesicle(GO:0030130) |
| 0.0 | 0.3 | GO:0016342 | catenin complex(GO:0016342) |
| 0.0 | 0.2 | GO:0045254 | pyruvate dehydrogenase complex(GO:0045254) |
| 0.0 | 0.2 | GO:0044327 | dendritic spine head(GO:0044327) |
| 0.0 | 0.2 | GO:0034362 | low-density lipoprotein particle(GO:0034362) |
| 0.0 | 0.1 | GO:1902937 | inward rectifier potassium channel complex(GO:1902937) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.0 | 0.9 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.1 | 0.6 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 0.0 | 0.6 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.0 | 0.4 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.0 | 0.4 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.0 | 0.3 | GO:0019534 | toxin transporter activity(GO:0019534) |
| 0.0 | 0.3 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
| 0.0 | 0.3 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.0 | 0.2 | GO:0004024 | alcohol dehydrogenase activity, zinc-dependent(GO:0004024) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.6 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 0.7 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.0 | 0.7 | REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.0 | 0.2 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 0.2 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.0 | 0.2 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.0 | 0.2 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |