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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for CXXC1
Z-value: 1.77
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Transcription factors associated with CXXC1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CXXC1 | hg19_v2_chr18_-_47813940_47814021 | -0.28 | 5.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_183989157 Show fit | 1.39 |
ENST00000541912.1
|
nucleoporin 35kDa |
|
| chr2_+_67624430 Show fit | 1.08 |
ENST00000272342.5
|
Ewing tumor-associated antigen 1 |
|
| chr15_+_63414760 Show fit | 0.84 |
ENST00000557972.1
|
lactamase, beta |
|
| chr3_-_150264272 Show fit | 0.82 |
ENST00000491660.1
ENST00000487153.1 ENST00000239944.2 |
stress-associated endoplasmic reticulum protein 1 |
|
| chr4_+_187112674 Show fit | 0.81 |
ENST00000378802.4
|
cytochrome P450, family 4, subfamily V, polypeptide 2 |
|
| chr15_+_55611128 Show fit | 0.80 |
ENST00000164305.5
ENST00000539642.1 |
phosphatidylinositol glycan anchor biosynthesis, class B |
|
| chr2_+_183989083 Show fit | 0.79 |
ENST00000295119.4
|
nucleoporin 35kDa |
|
| chr6_-_113953705 Show fit | 0.76 |
ENST00000452675.1
|
RP11-367G18.1 |
|
| chr2_+_9563769 Show fit | 0.75 |
ENST00000475482.1
|
cleavage and polyadenylation specific factor 3, 73kDa |
|
| chr3_+_178865887 Show fit | 0.75 |
ENST00000477735.1
|
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
Network of associatons between targets according to the STRING database.
First level regulatory network of CXXC1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.4 | GO:0006999 | nuclear pore organization(GO:0006999) |
| 0.1 | 3.2 | GO:0051382 | kinetochore assembly(GO:0051382) |
| 0.3 | 2.0 | GO:1902035 | positive regulation of hematopoietic stem cell proliferation(GO:1902035) |
| 0.3 | 1.2 | GO:0009107 | lipoate biosynthetic process(GO:0009107) |
| 0.2 | 1.1 | GO:0000960 | mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960) |
| 0.2 | 1.1 | GO:0006041 | glucosamine metabolic process(GO:0006041) |
| 0.2 | 1.1 | GO:0046469 | platelet activating factor metabolic process(GO:0046469) |
| 0.0 | 1.1 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
| 0.0 | 1.1 | GO:1904355 | positive regulation of telomere capping(GO:1904355) |
| 0.0 | 1.1 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.5 | GO:0005652 | nuclear lamina(GO:0005652) |
| 0.0 | 1.9 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.4 | 1.3 | GO:0000818 | nuclear MIS12/MIND complex(GO:0000818) |
| 0.1 | 1.2 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.0 | 1.2 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 1.1 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.0 | 1.1 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.1 | 1.0 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 0.1 | 1.0 | GO:0071439 | clathrin complex(GO:0071439) |
| 0.0 | 1.0 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.1 | 2.1 | GO:0008409 | 5'-3' exonuclease activity(GO:0008409) |
| 0.2 | 1.6 | GO:0043515 | kinetochore binding(GO:0043515) |
| 0.0 | 1.4 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.4 | 1.2 | GO:0016992 | lipoate synthase activity(GO:0016992) radical SAM enzyme activity(GO:0070283) |
| 0.2 | 1.2 | GO:0004376 | glycolipid mannosyltransferase activity(GO:0004376) |
| 0.1 | 1.1 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.0 | 1.1 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 0.0 | 1.1 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.0 | 1.0 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 1.5 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 1.5 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 1.2 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 0.9 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 0.9 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.0 | 0.8 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.0 | 0.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 0.7 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 0.6 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.3 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 4.1 | REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT | Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript |
| 0.0 | 1.7 | REACTOME PHOSPHORYLATION OF THE APC C | Genes involved in Phosphorylation of the APC/C |
| 0.0 | 1.3 | REACTOME DOUBLE STRAND BREAK REPAIR | Genes involved in Double-Strand Break Repair |
| 0.1 | 1.2 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.1 | 1.1 | REACTOME ACYL CHAIN REMODELLING OF PG | Genes involved in Acyl chain remodelling of PG |
| 0.0 | 1.1 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.0 | 1.1 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.0 | 1.0 | REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK | Genes involved in Energy dependent regulation of mTOR by LKB1-AMPK |
| 0.0 | 1.0 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |