ISMARA results: CUX1

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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for CUX1

Z-value: 0.74

Motif logo

Transcription factors associated with CUX1

Gene Symbol	Gene ID	Gene Info
CUX1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000257923.5	cut like homeobox 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
CUX1	hg19_v2_chr7_+_101460882_101460923	0.48	3.4e-01	Click!

Activity profile of CUX1 motif

Sorted Z-values of CUX1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_-_9482010 Show fit	0.41	ENST00000596206.1	AC132192.1 Ensembl NCBI GeneCards UniProt NextProt Show fit	LOC644656 protein; Uncharacterized protein
chr19_-_33182616 Show fit	0.31	ENST00000592431.1	CTD-2538C1.2 Ensembl NCBI GeneCards UniProt NextProt Show fit	CTD-2538C1.2
chr14_+_38065052 Show fit	0.31	ENST00000556845.1	TTC6 Ensembl NCBI GeneCards UniProt NextProt Show fit	tetratricopeptide repeat domain 6
chr1_+_104615595 Show fit	0.29	ENST00000418362.1	RP11-364B6.1 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP11-364B6.1
chr3_-_142720267 Show fit	0.29	ENST00000597953.1	RP11-91G21.1 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP11-91G21.1
chr14_-_75389925 Show fit	0.28	ENST00000556776.1	RPS6KL1 Ensembl NCBI GeneCards UniProt NextProt Show fit	ribosomal protein S6 kinase-like 1
chr1_+_155583012 Show fit	0.26	ENST00000462250.2	MSTO1 Ensembl NCBI GeneCards UniProt NextProt Show fit	misato 1, mitochondrial distribution and morphology regulator
chr3_-_119379719 Show fit	0.26	ENST00000493094.1	POPDC2 Ensembl NCBI GeneCards UniProt NextProt Show fit	popeye domain containing 2
chr19_+_5681011 Show fit	0.26	ENST00000581893.1 ENST00000411793.2 ENST00000301382.4 ENST00000581773.1 ENST00000423665.2 ENST00000583928.1 ENST00000342970.2 ENST00000422535.2 ENST00000581521.1 ENST00000339423.2	HSD11B1L Ensembl NCBI GeneCards UniProt NextProt Show fit	hydroxysteroid (11-beta) dehydrogenase 1-like
chr1_-_156786634 Show fit	0.25	ENST00000392306.2 ENST00000368199.3	SH2D2A Ensembl NCBI GeneCards UniProt NextProt Show fit	SH2 domain containing 2A

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of CUX1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.3	GO:0051388	positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.1	0.2	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.2	GO:0046086	adenosine biosynthetic process(GO:0046086)
0.0	0.2	GO:0072221	distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221)
0.0	0.2	GO:0061760	antifungal innate immune response(GO:0061760)
0.0	0.2	GO:0034372	very-low-density lipoprotein particle remodeling(GO:0034372)
0.0	0.2	GO:0045229	cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.0	0.2	GO:0070164	negative regulation of adiponectin secretion(GO:0070164)
0.0	0.2	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.0	0.2	GO:1901387	positive regulation of voltage-gated calcium channel activity(GO:1901387)

Showing 1 to 10 of 64 entries

Gene overrepresentation in cellular_component category:

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Total log-likelihood	Term	Description
0.3	GO:0031209	SCAR complex(GO:0031209)
0.2	GO:0032541	cortical endoplasmic reticulum(GO:0032541)
0.2	GO:0031089	platelet dense granule lumen(GO:0031089)
0.1	GO:0038039	G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1	GO:0005967	mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1	GO:0042721	mitochondrial inner membrane protein insertion complex(GO:0042721)
0.1	GO:0033011	perinuclear theca(GO:0033011)
0.1	GO:0097444	spine apparatus(GO:0097444)
0.1	GO:0031262	Ndc80 complex(GO:0031262)
0.1	GO:0032010	phagolysosome(GO:0032010)

Showing 1 to 10 of 13 entries

Gene overrepresentation in molecular_function category:

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Total log-likelihood	Term	Description
0.2	GO:0004637	phosphoribosylamine-glycine ligase activity(GO:0004637) phosphoribosylformylglycinamidine cyclo-ligase activity(GO:0004641) phosphoribosylglycinamide formyltransferase activity(GO:0004644)
0.2	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.2	GO:0005499	vitamin D binding(GO:0005499)
0.2	GO:0052828	phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.2	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.2	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.2	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1	GO:0016418	S-acetyltransferase activity(GO:0016418)
0.1	GO:0004449	isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.1	GO:1990698	palmitoleoyltransferase activity(GO:1990698)

Showing 1 to 10 of 39 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.0	PID EPO PATHWAY	EPO signaling pathway

Showing 1 to 1 of 1 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
0.3	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.2	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.1	REACTOME ION CHANNEL TRANSPORT	Genes involved in Ion channel transport

Showing 1 to 4 of 4 entries

Results for CUX1

Z-value: 0.74

Motif logo

Transcription factors associated with CUX1

Activity-expression correlation:

Activity profile of CUX1 motif

Sorted Z-values of CUX1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of CUX1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: