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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for CREB3L2
Z-value: 0.77
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Transcription factors associated with CREB3L2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CREB3L2 | hg19_v2_chr7_-_137686791_137686821 | -0.48 | 3.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_68835991 Show fit | 0.48 |
ENST00000546086.1
|
RP11-81H14.2 |
|
| chr9_+_96928516 Show fit | 0.45 |
ENST00000602703.1
|
RP11-2B6.3 |
|
| chr2_+_172543919 Show fit | 0.33 |
ENST00000452242.1
ENST00000340296.4 |
dynein, cytoplasmic 1, intermediate chain 2 |
|
| chr20_+_2633269 Show fit | 0.33 |
ENST00000445139.1
|
NOP56 ribonucleoprotein |
|
| chr4_+_186347388 Show fit | 0.30 |
ENST00000511138.1
ENST00000511581.1 |
chromosome 4 open reading frame 47 |
|
| chr1_-_42921915 Show fit | 0.30 |
ENST00000372565.3
ENST00000433602.2 |
zinc finger, MYND-type containing 12 |
|
| chr15_+_89182178 Show fit | 0.29 |
ENST00000559876.1
|
interferon stimulated exonuclease gene 20kDa |
|
| chr17_-_73937028 Show fit | 0.29 |
ENST00000586631.2
|
Fas (TNFRSF6) binding factor 1 |
|
| chr2_+_172543967 Show fit | 0.29 |
ENST00000534253.2
ENST00000263811.4 ENST00000397119.3 ENST00000410079.3 ENST00000438879.1 |
dynein, cytoplasmic 1, intermediate chain 2 |
|
| chr15_-_40213080 Show fit | 0.28 |
ENST00000561100.1
|
G protein-coupled receptor 176 |
Network of associatons between targets according to the STRING database.
First level regulatory network of CREB3L2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.8 | GO:2000580 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 0.0 | 0.6 | GO:0021680 | cerebellar Purkinje cell layer development(GO:0021680) |
| 0.1 | 0.5 | GO:1904808 | regulation of protein oxidation(GO:1904806) positive regulation of protein oxidation(GO:1904808) |
| 0.1 | 0.5 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.0 | 0.5 | GO:0031584 | activation of phospholipase D activity(GO:0031584) |
| 0.0 | 0.4 | GO:0006884 | cell volume homeostasis(GO:0006884) |
| 0.1 | 0.3 | GO:2000656 | regulation of apolipoprotein binding(GO:2000656) negative regulation of apolipoprotein binding(GO:2000657) |
| 0.1 | 0.3 | GO:0033274 | response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829) |
| 0.0 | 0.3 | GO:0043654 | recognition of apoptotic cell(GO:0043654) |
| 0.0 | 0.3 | GO:1901857 | positive regulation of cellular respiration(GO:1901857) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.1 | 0.5 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.0 | 0.4 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.1 | 0.3 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 0.0 | 0.3 | GO:0097539 | ciliary transition fiber(GO:0097539) |
| 0.0 | 0.2 | GO:1990037 | Lewy body core(GO:1990037) |
| 0.0 | 0.2 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.0 | 0.2 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 0.0 | 0.1 | GO:0042565 | RNA nuclear export complex(GO:0042565) |
| 0.0 | 0.1 | GO:0000214 | tRNA-intron endonuclease complex(GO:0000214) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.2 | 0.5 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.0 | 0.5 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.0 | 0.5 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 0.5 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.1 | 0.4 | GO:0004461 | lactose synthase activity(GO:0004461) |
| 0.1 | 0.3 | GO:0070815 | peptidyl-lysine 5-dioxygenase activity(GO:0070815) |
| 0.1 | 0.3 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
| 0.1 | 0.3 | GO:1990050 | phosphatidic acid transporter activity(GO:1990050) |
| 0.0 | 0.3 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 0.3 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 0.3 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |
| 0.0 | 0.3 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.1 | 0.2 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 0.2 | REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |