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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for CREB3L1_CREB3
Z-value: 0.87
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Transcription factors associated with CREB3L1_CREB3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CREB3L1 | hg19_v2_chr11_+_46316677_46316719 | 0.84 | 3.5e-02 | Click! |
| CREB3 | hg19_v2_chr9_+_35732312_35732332 | 0.47 | 3.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_50031547 Show fit | 0.86 |
ENST00000597801.1
|
reticulocalbin 3, EF-hand calcium binding domain |
|
| chr6_+_31916733 Show fit | 0.47 |
ENST00000483004.1
|
complement factor B |
|
| chr6_+_32936942 Show fit | 0.42 |
ENST00000496118.2
|
bromodomain containing 2 |
|
| chr22_+_38864041 Show fit | 0.40 |
ENST00000216014.4
ENST00000409006.3 |
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 |
|
| chr5_+_68389807 Show fit | 0.36 |
ENST00000380860.4
ENST00000504103.1 ENST00000502979.1 |
solute carrier family 30 (zinc transporter), member 5 |
|
| chr4_+_165675197 Show fit | 0.31 |
ENST00000515485.1
|
RP11-294O2.2 |
|
| chr14_+_24600484 Show fit | 0.29 |
ENST00000267426.5
|
fat storage-inducing transmembrane protein 1 |
|
| chr3_-_57583185 Show fit | 0.27 |
ENST00000463880.1
|
ADP-ribosylation factor 4 |
|
| chr12_-_105352047 Show fit | 0.27 |
ENST00000432951.1
ENST00000415674.1 ENST00000424946.1 |
solute carrier family 41 (magnesium transporter), member 2 |
|
| chr19_+_10527449 Show fit | 0.26 |
ENST00000592685.1
ENST00000380702.2 |
phosphodiesterase 4A, cAMP-specific |
Network of associatons between targets according to the STRING database.
First level regulatory network of CREB3L1_CREB3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | GO:0031584 | activation of phospholipase D activity(GO:0031584) |
| 0.0 | 0.5 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.1 | 0.4 | GO:0035407 | histone H3-T11 phosphorylation(GO:0035407) |
| 0.0 | 0.4 | GO:0061088 | regulation of sequestering of zinc ion(GO:0061088) |
| 0.0 | 0.4 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
| 0.0 | 0.3 | GO:0010890 | positive regulation of sequestering of triglyceride(GO:0010890) |
| 0.0 | 0.3 | GO:1903830 | magnesium ion transmembrane transport(GO:1903830) |
| 0.1 | 0.2 | GO:0035022 | positive regulation of Rac protein signal transduction(GO:0035022) |
| 0.1 | 0.2 | GO:1990426 | homologous recombination-dependent replication fork processing(GO:1990426) |
| 0.0 | 0.2 | GO:0044314 | protein K27-linked ubiquitination(GO:0044314) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | GO:0098574 | cytoplasmic side of lysosomal membrane(GO:0098574) |
| 0.0 | 0.3 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.1 | 0.2 | GO:0032783 | ELL-EAF complex(GO:0032783) |
| 0.0 | 0.2 | GO:0070847 | core mediator complex(GO:0070847) |
| 0.0 | 0.2 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.0 | 0.2 | GO:0030123 | AP-3 adaptor complex(GO:0030123) |
| 0.0 | 0.1 | GO:0031372 | UBC13-MMS2 complex(GO:0031372) |
| 0.0 | 0.1 | GO:0031515 | tRNA (m1A) methyltransferase complex(GO:0031515) |
| 0.0 | 0.1 | GO:0020016 | ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018) |
| 0.0 | 0.1 | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane(GO:0098554) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.0 | 0.5 | GO:0001848 | complement binding(GO:0001848) |
| 0.0 | 0.5 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.1 | 0.4 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
| 0.0 | 0.4 | GO:0046923 | ER retention sequence binding(GO:0046923) |
| 0.0 | 0.4 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.0 | 0.3 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.1 | 0.2 | GO:0005427 | proton-dependent oligopeptide secondary active transmembrane transporter activity(GO:0005427) secondary active oligopeptide transmembrane transporter activity(GO:0015322) |
| 0.1 | 0.2 | GO:0000224 | peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity(GO:0000224) |
| 0.0 | 0.2 | GO:0004830 | tryptophan-tRNA ligase activity(GO:0004830) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 0.4 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.0 | 0.5 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.0 | 0.4 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |