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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for CPEB1
Z-value: 1.02
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Transcription factors associated with CPEB1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CPEB1 | hg19_v2_chr15_-_83316254_83316368 | 0.22 | 6.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_159895275 Show fit | 1.56 |
ENST00000517927.1
|
microRNA 146a |
|
| chr8_-_25281747 Show fit | 0.88 |
ENST00000421054.2
|
gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) |
|
| chr4_-_74864386 Show fit | 0.86 |
ENST00000296027.4
|
chemokine (C-X-C motif) ligand 5 |
|
| chr10_-_106240032 Show fit | 0.76 |
ENST00000447860.1
|
RP11-127O4.3 |
|
| chr4_-_74904398 Show fit | 0.76 |
ENST00000296026.4
|
chemokine (C-X-C motif) ligand 3 |
|
| chr2_-_25451065 Show fit | 0.66 |
ENST00000606328.1
|
RP11-458N5.1 |
|
| chr6_+_12290586 Show fit | 0.56 |
ENST00000379375.5
|
endothelin 1 |
|
| chr18_+_68002675 Show fit | 0.49 |
ENST00000584919.1
|
Uncharacterized protein |
|
| chr6_+_31105426 Show fit | 0.49 |
ENST00000547221.1
|
psoriasis susceptibility 1 candidate 1 |
|
| chr2_-_228244013 Show fit | 0.47 |
ENST00000304568.3
|
transmembrane 4 L six family member 20 |
Network of associatons between targets according to the STRING database.
First level regulatory network of CPEB1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.1 | 1.1 | GO:0048298 | positive regulation of isotype switching to IgA isotypes(GO:0048298) |
| 0.2 | 0.9 | GO:1990637 | response to prolactin(GO:1990637) |
| 0.2 | 0.6 | GO:0045208 | MAPK phosphatase export from nucleus(GO:0045208) MAPK phosphatase export from nucleus, leptomycin B sensitive(GO:0045209) |
| 0.1 | 0.6 | GO:0060585 | negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585) |
| 0.1 | 0.4 | GO:0010909 | regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730) |
| 0.0 | 0.4 | GO:0001554 | luteolysis(GO:0001554) |
| 0.0 | 0.4 | GO:0001502 | cartilage condensation(GO:0001502) |
| 0.0 | 0.4 | GO:0003416 | endochondral bone growth(GO:0003416) |
| 0.1 | 0.3 | GO:0061073 | ciliary body morphogenesis(GO:0061073) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane(GO:0098554) |
| 0.2 | 0.6 | GO:0048237 | rough endoplasmic reticulum lumen(GO:0048237) |
| 0.1 | 0.4 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
| 0.1 | 0.3 | GO:0000333 | telomerase catalytic core complex(GO:0000333) |
| 0.0 | 0.3 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.0 | 0.3 | GO:0098642 | network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) |
| 0.0 | 0.2 | GO:1990667 | PCSK9-AnxA2 complex(GO:1990667) |
| 0.0 | 0.2 | GO:1990037 | Lewy body core(GO:1990037) |
| 0.0 | 0.2 | GO:0002177 | manchette(GO:0002177) |
| 0.0 | 0.2 | GO:0045275 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.0 | 1.1 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 0.9 | GO:0005179 | hormone activity(GO:0005179) |
| 0.2 | 0.6 | GO:0031705 | bombesin receptor binding(GO:0031705) |
| 0.0 | 0.6 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.0 | 0.4 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 0.4 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 0.0 | 0.3 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.0 | 0.3 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.0 | 0.3 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.1 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.2 | 0.9 | REACTOME HORMONE LIGAND BINDING RECEPTORS | Genes involved in Hormone ligand-binding receptors |
| 0.0 | 0.9 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 0.3 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.0 | 0.2 | REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |
| 0.0 | 0.1 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 0.0 | 0.1 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.0 | 0.1 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |