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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for CEBPG
Z-value: 1.97
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Transcription factors associated with CEBPG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CEBPG | hg19_v2_chr19_+_33865218_33865254 | -0.26 | 6.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CEBPG
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.1 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.3 | 5.9 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 1.3 | 5.4 | GO:1990637 | response to prolactin(GO:1990637) |
| 0.2 | 3.1 | GO:0015939 | pantothenate metabolic process(GO:0015939) |
| 0.9 | 2.8 | GO:0051714 | positive regulation of cytolysis in other organism(GO:0051714) |
| 0.5 | 2.4 | GO:0015688 | iron chelate transport(GO:0015688) siderophore transport(GO:0015891) |
| 0.6 | 1.9 | GO:0001798 | positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894) |
| 0.3 | 1.9 | GO:0031622 | regulation of fever generation(GO:0031620) positive regulation of fever generation(GO:0031622) |
| 0.0 | 1.9 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
| 0.3 | 1.5 | GO:0008588 | release of cytoplasmic sequestered NF-kappaB(GO:0008588) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 15.9 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.1 | 8.9 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 3.5 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.6 | 2.9 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.1 | 1.4 | GO:0097255 | R2TP complex(GO:0097255) |
| 0.0 | 0.7 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.0 | 0.4 | GO:0019774 | proteasome core complex, beta-subunit complex(GO:0019774) |
| 0.0 | 0.3 | GO:0000275 | mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) |
| 0.0 | 0.3 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.0 | 0.2 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 15.8 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.2 | 6.3 | GO:0001848 | complement binding(GO:0001848) |
| 0.0 | 3.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.6 | 3.1 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
| 0.3 | 2.9 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.7 | 2.8 | GO:0008745 | N-acetylmuramoyl-L-alanine amidase activity(GO:0008745) |
| 0.0 | 2.1 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.1 | 1.9 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.2 | 1.4 | GO:0043141 | ATP-dependent 5'-3' DNA helicase activity(GO:0043141) |
| 0.2 | 1.2 | GO:0004735 | pyrroline-5-carboxylate reductase activity(GO:0004735) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.6 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.2 | 7.8 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.2 | 5.9 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.1 | 1.9 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 1.3 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 1.2 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 0.4 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.4 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 0.4 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.6 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.5 | 8.4 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.2 | 3.5 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 1.8 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 1.4 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.1 | 1.2 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 0.8 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 0.7 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.0 | 0.7 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 0.6 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |