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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for CEBPE_CEBPD
Z-value: 1.39
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Transcription factors associated with CEBPE_CEBPD
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CEBPD | hg19_v2_chr8_-_48651648_48651648 | -0.38 | 4.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CEBPE_CEBPD
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.9 | GO:0048246 | macrophage chemotaxis(GO:0048246) |
| 0.4 | 6.2 | GO:0015939 | pantothenate metabolic process(GO:0015939) |
| 0.0 | 4.9 | GO:0050918 | positive chemotaxis(GO:0050918) |
| 1.1 | 4.5 | GO:1990637 | response to prolactin(GO:1990637) |
| 0.2 | 4.3 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.1 | 2.5 | GO:0006825 | copper ion transport(GO:0006825) |
| 0.3 | 2.2 | GO:0031620 | regulation of fever generation(GO:0031620) positive regulation of fever generation(GO:0031622) |
| 0.7 | 2.0 | GO:0001798 | positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894) |
| 0.0 | 1.8 | GO:0000186 | activation of MAPKK activity(GO:0000186) |
| 0.1 | 1.0 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.9 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.0 | 6.3 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 4.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.2 | 4.7 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 3.7 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 0.8 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 0.6 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.0 | 0.5 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 0.3 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 0.0 | 0.2 | GO:0016222 | procollagen-proline 4-dioxygenase complex(GO:0016222) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.6 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 1.3 | 6.6 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
| 0.1 | 4.8 | GO:0001848 | complement binding(GO:0001848) |
| 0.0 | 4.5 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.0 | 3.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.2 | 2.4 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.0 | 2.1 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 1.8 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.1 | 1.6 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.0 | 1.1 | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.0 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.1 | 6.5 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 4.4 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.1 | 2.0 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 1.8 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 1.3 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 0.6 | PID S1P S1P1 PATHWAY | S1P1 pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 7.8 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.2 | 6.8 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.0 | 4.0 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 1.2 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.0 | 0.9 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.0 | 0.8 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 0.6 | REACTOME PLATELET SENSITIZATION BY LDL | Genes involved in Platelet sensitization by LDL |
| 0.0 | 0.4 | REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
| 0.0 | 0.3 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 0.2 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |