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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for CEBPA
Z-value: 2.10
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Transcription factors associated with CEBPA
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CEBPA | hg19_v2_chr19_-_33793430_33793470 | -0.40 | 4.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_18270182 Show fit | 3.89 |
ENST00000528349.1
ENST00000526900.1 ENST00000529528.1 ENST00000414546.2 ENST00000256733.4 |
serum amyloid A2 |
|
| chr11_-_18258342 Show fit | 3.66 |
ENST00000278222.4
|
serum amyloid A4, constitutive |
|
| chr18_-_61311485 Show fit | 3.19 |
ENST00000436264.1
ENST00000356424.6 ENST00000341074.5 |
serpin peptidase inhibitor, clade B (ovalbumin), member 4 |
|
| chr11_+_18287721 Show fit | 3.09 |
ENST00000356524.4
|
serum amyloid A1 |
|
| chr11_+_18287801 Show fit | 3.08 |
ENST00000532858.1
ENST00000405158.2 |
serum amyloid A1 |
|
| chr6_+_31895467 Show fit | 2.93 |
ENST00000556679.1
ENST00000456570.1 |
complement factor B Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B |
|
| chr6_+_31895480 Show fit | 2.74 |
ENST00000418949.2
ENST00000383177.3 ENST00000477310.1 |
complement component 2 Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B |
|
| chr2_+_228678550 Show fit | 2.50 |
ENST00000409189.3
ENST00000358813.4 |
chemokine (C-C motif) ligand 20 |
|
| chr4_+_74606223 Show fit | 2.50 |
ENST00000307407.3
ENST00000401931.1 |
interleukin 8 |
|
| chr12_+_72058130 Show fit | 2.25 |
ENST00000547843.1
|
THAP domain containing, apoptosis associated protein 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of CEBPA
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.5 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.3 | 5.2 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.2 | 3.8 | GO:0015939 | pantothenate metabolic process(GO:0015939) |
| 1.1 | 3.3 | GO:0042270 | protection from natural killer cell mediated cytotoxicity(GO:0042270) |
| 0.5 | 2.7 | GO:0015688 | iron chelate transport(GO:0015688) siderophore transport(GO:0015891) |
| 0.8 | 2.5 | GO:0045362 | regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) |
| 0.1 | 2.1 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 0.7 | 2.0 | GO:0002894 | positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894) |
| 0.4 | 2.0 | GO:0008588 | release of cytoplasmic sequestered NF-kappaB(GO:0008588) |
| 0.3 | 1.9 | GO:0031622 | regulation of fever generation(GO:0031620) positive regulation of fever generation(GO:0031622) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 13.9 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.1 | 9.5 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 3.1 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 3.0 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.0 | 1.7 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 1.6 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 1.6 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 1.0 | GO:0005605 | basal lamina(GO:0005605) |
| 0.1 | 0.8 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.1 | 0.8 | GO:0097255 | R2TP complex(GO:0097255) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 13.7 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.1 | 6.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.2 | 6.7 | GO:0001848 | complement binding(GO:0001848) |
| 0.0 | 4.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.9 | 4.3 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
| 0.8 | 2.5 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
| 0.1 | 2.2 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.0 | 2.0 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.3 | 1.8 | GO:0016822 | hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823) |
| 0.4 | 1.6 | GO:0008745 | N-acetylmuramoyl-L-alanine amidase activity(GO:0008745) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 6.2 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 5.2 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 4.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 2.5 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 2.1 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 2.1 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.1 | 1.7 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 1.6 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.0 | 1.2 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 8.7 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.2 | 7.5 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.1 | 4.5 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 2.1 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 1.8 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.0 | 1.5 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 1.3 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.0 | 1.0 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 0.8 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.0 | 0.6 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |