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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for BRCA1

Z-value: 0.40

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Transcription factors associated with BRCA1

Gene Symbol Gene ID Gene Info
BRCA1
ENSG00000012048.15 BRCA1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BRCA1hg19_v2_chr17_-_41277370_412774190.671.5e-01Click!

Activity profile of BRCA1 motif

Sorted Z-values of BRCA1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of BRCA1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr8_+_97773202 0.21 ENST00000519484.1
 CPQ
 carboxypeptidase Q
chr8_+_97773457 0.15 ENST00000521142.1
 CPQ
 carboxypeptidase Q
chr2_+_196522032 0.14 ENST00000418005.1
 SLC39A10
 solute carrier family 39 (zinc transporter), member 10
chr12_-_96336369 0.14 ENST00000546947.1
ENST00000546386.1
 CCDC38
 coiled-coil domain containing 38
chrX_-_46187069 0.10 ENST00000446884.1
 RP1-30G7.2
 RP1-30G7.2
chr4_+_619386 0.10 ENST00000496514.1
 PDE6B
 phosphodiesterase 6B, cGMP-specific, rod, beta
chr4_+_619347 0.10 ENST00000255622.6
 PDE6B
 phosphodiesterase 6B, cGMP-specific, rod, beta
chr2_+_223725723 0.10 ENST00000535678.1
 ACSL3
 acyl-CoA synthetase long-chain family member 3
chr20_+_9049682 0.09 ENST00000334005.3
ENST00000378473.3
 PLCB4
 phospholipase C, beta 4
chr20_+_52105495 0.09 ENST00000439873.2
 AL354993.1
 Cell growth-inhibiting protein 7; HCG1784586; Uncharacterized protein
chrX_+_49644470 0.09 ENST00000508866.2
 USP27X
 ubiquitin specific peptidase 27, X-linked
chr3_-_176914191 0.09 ENST00000437738.1
ENST00000424913.1
ENST00000443315.1
 TBL1XR1
 transducin (beta)-like 1 X-linked receptor 1
chr1_-_173020056 0.09 ENST00000239468.2
ENST00000404377.3
 TNFSF18
 tumor necrosis factor (ligand) superfamily, member 18
chr3_-_27410847 0.09 ENST00000429845.2
ENST00000341435.5
ENST00000435750.1
 NEK10
 NIMA-related kinase 10
chr3_-_176914238 0.08 ENST00000430069.1
ENST00000428970.1
 TBL1XR1
 transducin (beta)-like 1 X-linked receptor 1
chr2_-_25194476 0.08 ENST00000534855.1
 DNAJC27
 DnaJ (Hsp40) homolog, subfamily C, member 27
chr17_-_42019836 0.08 ENST00000225992.3
 PPY
 pancreatic polypeptide
chr13_-_50018140 0.07 ENST00000410043.1
ENST00000347776.5
 CAB39L
 calcium binding protein 39-like
chr5_+_140079919 0.07 ENST00000274712.3
 ZMAT2
 zinc finger, matrin-type 2
chr10_-_95209 0.07 ENST00000332708.5
ENST00000309812.4
 TUBB8
 tubulin, beta 8 class VIII
chr2_-_134326009 0.07 ENST00000409261.1
ENST00000409213.1
 NCKAP5
 NCK-associated protein 5
chr18_-_49557 0.06 ENST00000308911.6
 RP11-683L23.1
 Tubulin beta-8 chain-like protein LOC260334
chr12_+_510795 0.06 ENST00000412006.2
 CCDC77
 coiled-coil domain containing 77
chr12_-_49418407 0.06 ENST00000526209.1
 KMT2D
 lysine (K)-specific methyltransferase 2D
chr4_-_140005443 0.06 ENST00000510408.1
ENST00000420916.2
ENST00000358635.3
 ELF2
 E74-like factor 2 (ets domain transcription factor)
chr2_+_108994466 0.06 ENST00000272452.2
 SULT1C4
 sulfotransferase family, cytosolic, 1C, member 4
chr13_-_50018241 0.06 ENST00000409308.1
 CAB39L
 calcium binding protein 39-like
chr17_-_7082861 0.05 ENST00000269299.3
 ASGR1
 asialoglycoprotein receptor 1
chr5_-_124082279 0.05 ENST00000513986.1
 ZNF608
 zinc finger protein 608
chr9_+_35792151 0.05 ENST00000342694.2
 NPR2
 natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr9_-_124976154 0.05 ENST00000482062.1
 LHX6
 LIM homeobox 6
chr19_+_46000479 0.05 ENST00000456399.2
 PPM1N
 protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)
chr4_-_48782259 0.05 ENST00000507711.1
ENST00000358350.4
ENST00000537810.1
ENST00000264319.7
 FRYL
 FRY-like
chr1_+_70687137 0.05 ENST00000436161.2
 SRSF11
 serine/arginine-rich splicing factor 11
chr4_+_185570767 0.05 ENST00000314970.6
ENST00000515774.1
ENST00000503752.1
 PRIMPOL
 primase and polymerase (DNA-directed)
chr12_+_510742 0.05 ENST00000239830.4
 CCDC77
 coiled-coil domain containing 77
chr10_-_95504 0.05 ENST00000447903.2
 TUBB8
 tubulin, beta 8 class VIII
chr13_-_31038370 0.05 ENST00000399489.1
ENST00000339872.4
 HMGB1
 high mobility group box 1
chr5_+_145583107 0.04 ENST00000506502.1
 RBM27
 RNA binding motif protein 27
chr9_-_86593238 0.04 ENST00000351839.3
 HNRNPK
 heterogeneous nuclear ribonucleoprotein K
chr1_-_160232291 0.04 ENST00000368074.1
ENST00000447377.1
 DCAF8
 DDB1 and CUL4 associated factor 8
chr1_+_159141397 0.04 ENST00000368124.4
ENST00000368125.4
ENST00000416746.1
 CADM3
 cell adhesion molecule 3
chr5_-_68665084 0.04 ENST00000509462.1
 TAF9
 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
chr17_-_8702667 0.04 ENST00000329805.4
 MFSD6L
 major facilitator superfamily domain containing 6-like
chr5_-_68665296 0.04 ENST00000512152.1
ENST00000503245.1
ENST00000512561.1
ENST00000380822.4
 TAF9
 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
chr5_+_145583156 0.04 ENST00000265271.5
 RBM27
 RNA binding motif protein 27
chr6_+_16129308 0.04 ENST00000356840.3
ENST00000349606.4
 MYLIP
 myosin regulatory light chain interacting protein
chr8_-_81083341 0.04 ENST00000519303.2
 TPD52
 tumor protein D52
chr15_-_72612470 0.04 ENST00000287202.5
 CELF6
 CUGBP, Elav-like family member 6
chr5_-_68664989 0.04 ENST00000508954.1
 TAF9
 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
chr2_+_223725652 0.04 ENST00000357430.3
ENST00000392066.3
 ACSL3
 acyl-CoA synthetase long-chain family member 3
chr5_-_68665469 0.04 ENST00000217893.5
 TAF9
 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
chr13_+_27825446 0.04 ENST00000311549.6
 RPL21
 ribosomal protein L21
chr5_-_142023766 0.03 ENST00000394496.2
 FGF1
 fibroblast growth factor 1 (acidic)
chrX_-_70288234 0.03 ENST00000276105.3
ENST00000374274.3
 SNX12
 sorting nexin 12
chr11_-_13484713 0.03 ENST00000526841.1
ENST00000529708.1
ENST00000278174.5
ENST00000528120.1
 BTBD10
 BTB (POZ) domain containing 10
chr14_-_75179774 0.03 ENST00000555249.1
ENST00000556202.1
ENST00000356357.4
ENST00000338772.5
 AREL1
AC007956.1
 apoptosis resistant E3 ubiquitin protein ligase 1
Full-length cDNA 5-PRIME end of clone CS0CAP004YO05 of Thymus of Homo sapiens (human); Uncharacterized protein
chr10_+_28822636 0.03 ENST00000442148.1
ENST00000448193.1
 WAC
 WW domain containing adaptor with coiled-coil
chr2_+_98703595 0.03 ENST00000435344.1
 VWA3B
 von Willebrand factor A domain containing 3B
chr6_+_42981922 0.03 ENST00000326974.4
ENST00000244670.8
 KLHDC3
 kelch domain containing 3
chr7_+_99717230 0.03 ENST00000262932.3
 CNPY4
 canopy FGF signaling regulator 4
chr12_-_67072714 0.03 ENST00000545666.1
ENST00000398016.3
ENST00000359742.4
ENST00000286445.7
ENST00000538211.1
 GRIP1
 glutamate receptor interacting protein 1
chr5_+_139027877 0.03 ENST00000302517.3
 CXXC5
 CXXC finger protein 5
chr10_-_61900762 0.03 ENST00000355288.2
 ANK3
 ankyrin 3, node of Ranvier (ankyrin G)
chr2_-_152118352 0.02 ENST00000331426.5
 RBM43
 RNA binding motif protein 43
chr12_-_122879969 0.02 ENST00000540304.1
 CLIP1
 CAP-GLY domain containing linker protein 1
chr1_-_160232197 0.02 ENST00000419626.1
ENST00000610139.1
ENST00000475733.1
ENST00000407642.2
ENST00000368073.3
ENST00000326837.2
 DCAF8
 DDB1 and CUL4 associated factor 8
chr12_-_95510743 0.02 ENST00000551521.1
 FGD6
 FYVE, RhoGEF and PH domain containing 6
chr6_-_42981651 0.02 ENST00000244711.3
 MEA1
 male-enhanced antigen 1
chr11_+_117947724 0.02 ENST00000534111.1
 TMPRSS4
 transmembrane protease, serine 4
chr1_-_160232312 0.02 ENST00000440682.1
 DCAF8
 DDB1 and CUL4 associated factor 8
chr13_+_27825706 0.02 ENST00000272274.4
ENST00000319826.4
ENST00000326092.4
 RPL21
 ribosomal protein L21
chr3_+_185303962 0.02 ENST00000296257.5
 SENP2
 SUMO1/sentrin/SMT3 specific peptidase 2
chr14_+_21510385 0.02 ENST00000298690.4
 RNASE7
 ribonuclease, RNase A family, 7
chr1_-_170043709 0.02 ENST00000367767.1
ENST00000361580.2
ENST00000538366.1
 KIFAP3
 kinesin-associated protein 3
chr14_+_103058948 0.02 ENST00000262241.6
 RCOR1
 REST corepressor 1
chrX_+_10124977 0.02 ENST00000380833.4
 CLCN4
 chloride channel, voltage-sensitive 4
chr7_+_73868439 0.02 ENST00000424337.2
 GTF2IRD1
 GTF2I repeat domain containing 1
chr10_+_92631709 0.02 ENST00000413330.1
ENST00000277882.3
 RPP30
 ribonuclease P/MRP 30kDa subunit
chr19_-_37663332 0.02 ENST00000392157.2
 ZNF585A
 zinc finger protein 585A
chr11_+_47291645 0.02 ENST00000395336.3
ENST00000402192.2
 MADD
 MAP-kinase activating death domain
chr9_-_43133544 0.02 ENST00000254835.2
 ANKRD20A3
 ankyrin repeat domain 20 family, member A3
chr1_+_161736072 0.02 ENST00000367942.3
 ATF6
 activating transcription factor 6
chr3_+_187461442 0.02 ENST00000450760.1
 RP11-211G3.2
 RP11-211G3.2
chr11_+_47291193 0.02 ENST00000428807.1
ENST00000402799.1
ENST00000406482.1
ENST00000349238.3
ENST00000311027.5
ENST00000407859.3
ENST00000395344.3
ENST00000444117.1
 MADD
 MAP-kinase activating death domain
chr1_+_10271674 0.02 ENST00000377086.1
 KIF1B
 kinesin family member 1B
chr18_-_23671139 0.01 ENST00000579061.1
ENST00000542420.2
 SS18
 synovial sarcoma translocation, chromosome 18
chr18_+_19749386 0.01 ENST00000269216.3
 GATA6
 GATA binding protein 6
chr1_+_70687079 0.01 ENST00000395136.2
 SRSF11
 serine/arginine-rich splicing factor 11
chr11_-_110583912 0.01 ENST00000533353.1
ENST00000527598.1
 ARHGAP20
 Rho GTPase activating protein 20
chr15_-_58358607 0.01 ENST00000249750.4
 ALDH1A2
 aldehyde dehydrogenase 1 family, member A2
chr10_+_102295616 0.01 ENST00000299163.6
 HIF1AN
 hypoxia inducible factor 1, alpha subunit inhibitor
chr1_-_115301235 0.01 ENST00000525878.1
 CSDE1
 cold shock domain containing E1, RNA-binding
chrX_-_10851762 0.01 ENST00000380785.1
ENST00000380787.1
 MID1
 midline 1 (Opitz/BBB syndrome)
chr8_-_116681221 0.01 ENST00000395715.3
 TRPS1
 trichorhinophalangeal syndrome I
chr10_+_93683519 0.01 ENST00000265990.6
 BTAF1
 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa
chr19_-_6057282 0.01 ENST00000592281.1
 RFX2
 regulatory factor X, 2 (influences HLA class II expression)
chr12_-_12491608 0.01 ENST00000545735.1
 MANSC1
 MANSC domain containing 1
chr17_-_41739283 0.01 ENST00000393661.2
ENST00000318579.4
 MEOX1
 mesenchyme homeobox 1
chr17_+_36584662 0.01 ENST00000431231.2
ENST00000437668.3
 ARHGAP23
 Rho GTPase activating protein 23
chrX_-_77150985 0.01 ENST00000358075.6
 MAGT1
 magnesium transporter 1
chr6_-_170862322 0.01 ENST00000262193.6
 PSMB1
 proteasome (prosome, macropain) subunit, beta type, 1
chr7_-_6010263 0.00 ENST00000455618.2
ENST00000405415.1
ENST00000404406.1
ENST00000542644.1
 RSPH10B
 radial spoke head 10 homolog B (Chlamydomonas)
chr2_-_158182105 0.00 ENST00000409925.1
 ERMN
 ermin, ERM-like protein
chr13_-_99910673 0.00 ENST00000397473.2
ENST00000397470.2
 GPR18
 G protein-coupled receptor 18
chr13_+_103046954 0.00 ENST00000606448.1
 FGF14-AS2
 FGF14 antisense RNA 2
chr14_-_94942548 0.00 ENST00000298845.7
 SERPINA9
 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9
chr7_-_78400364 0.00 ENST00000535697.1
 MAGI2
 membrane associated guanylate kinase, WW and PDZ domain containing 2
chr15_-_88799948 0.00 ENST00000394480.2
 NTRK3
 neurotrophic tyrosine kinase, receptor, type 3
chr14_-_94942527 0.00 ENST00000448305.2
 SERPINA9
 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:2001247 positive regulation of phosphatidylcholine biosynthetic process(GO:2001247)
0.0 0.1 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
0.0 0.1 GO:1903615 regulation of protein tyrosine phosphatase activity(GO:1903613) positive regulation of protein tyrosine phosphatase activity(GO:1903615)
0.0 0.1 GO:2000329 negative regulation of T-helper 17 cell lineage commitment(GO:2000329)
0.0 0.4 GO:0006590 thyroid hormone generation(GO:0006590)
0.0 0.0 GO:0032072 plasmacytoid dendritic cell activation(GO:0002270) regulation of restriction endodeoxyribonuclease activity(GO:0032072) T-helper 1 cell activation(GO:0035711)
0.0 0.1 GO:0045204 MAPK export from nucleus(GO:0045204)
0.0 0.2 GO:0060613 fat pad development(GO:0060613)
0.0 0.2 GO:0000492 box C/D snoRNP assembly(GO:0000492)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0000125 PCAF complex(GO:0000125)
0.0 0.1 GO:0072687 meiotic spindle(GO:0072687)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0070573 metallodipeptidase activity(GO:0070573)
0.0 0.1 GO:0003896 DNA primase activity(GO:0003896)