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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for BPTF
Z-value: 1.42
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Transcription factors associated with BPTF
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BPTF | hg19_v2_chr17_+_65821780_65821826 | 0.57 | 2.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_41465674 Show fit | 1.00 |
ENST00000592135.1
ENST00000587874.1 ENST00000588654.1 ENST00000592094.1 |
long intergenic non-protein coding RNA 910 |
|
| chr12_+_65996599 Show fit | 1.00 |
ENST00000539116.1
ENST00000541391.1 |
RP11-221N13.3 |
|
| chr17_+_58018269 Show fit | 0.94 |
ENST00000591035.1
|
Uncharacterized protein |
|
| chr20_+_55099542 Show fit | 0.89 |
ENST00000371328.3
|
family with sequence similarity 209, member A |
|
| chr16_+_21623958 Show fit | 0.82 |
ENST00000568826.1
|
methyltransferase like 9 |
|
| chr17_+_4692230 Show fit | 0.80 |
ENST00000331264.7
|
glycolipid transfer protein domain containing 2 |
|
| chr3_-_4927447 Show fit | 0.76 |
ENST00000449914.1
|
Uncharacterized protein |
|
| chr15_+_66585555 Show fit | 0.74 |
ENST00000319194.5
ENST00000525134.2 ENST00000441424.2 |
DIS3 mitotic control homolog (S. cerevisiae)-like |
|
| chr4_-_140544386 Show fit | 0.70 |
ENST00000561977.1
|
RP11-308D13.3 |
|
| chr4_+_165675197 Show fit | 0.68 |
ENST00000515485.1
|
RP11-294O2.2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of BPTF
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | GO:0007079 | mitotic chromosome movement towards spindle pole(GO:0007079) |
| 0.0 | 0.9 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
| 0.0 | 0.9 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.1 | 0.8 | GO:1904383 | response to sodium phosphate(GO:1904383) |
| 0.0 | 0.8 | GO:0016075 | rRNA catabolic process(GO:0016075) |
| 0.0 | 0.8 | GO:0006370 | 7-methylguanosine mRNA capping(GO:0006370) |
| 0.0 | 0.8 | GO:0042274 | ribosomal small subunit biogenesis(GO:0042274) |
| 0.1 | 0.7 | GO:1903265 | positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265) |
| 0.0 | 0.7 | GO:0006071 | glycerol metabolic process(GO:0006071) |
| 0.0 | 0.7 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.1 | 1.4 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.0 | 1.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 1.1 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.0 | 1.1 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 0.9 | GO:0001527 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.1 | 0.7 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.1 | 0.7 | GO:0097169 | AIM2 inflammasome complex(GO:0097169) |
| 0.0 | 0.7 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 0.6 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 1.3 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.0 | 1.2 | GO:0008094 | DNA-dependent ATPase activity(GO:0008094) |
| 0.0 | 1.1 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 0.0 | 0.9 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.0 | 0.8 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 0.2 | 0.7 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 0.1 | 0.7 | GO:0004376 | glycolipid mannosyltransferase activity(GO:0004376) |
| 0.0 | 0.7 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.1 | 0.6 | GO:0047522 | 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 1.4 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.3 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 1.1 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 1.1 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 1.1 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 0.9 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 0.7 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 0.6 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.5 | PID S1P S1P2 PATHWAY | S1P2 pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 0.9 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.0 | 0.9 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.0 | 0.8 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.0 | 0.7 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 0.7 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 0.6 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.0 | 0.6 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.0 | 0.6 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 0.0 | 0.6 | REACTOME G2 M CHECKPOINTS | Genes involved in G2/M Checkpoints |