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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for BBX

Z-value: 0.53

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Transcription factors associated with BBX

Gene Symbol Gene ID Gene Info
ENSG00000114439.14 BBX high mobility group box domain containing

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BBXhg19_v2_chr3_+_107241783_107241850-0.731.0e-01Click!

Activity profile of BBX motif

Sorted Z-values of BBX motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_119669160 0.56 ENST00000514240.1
CTC-552D5.1
chr11_+_18154059 0.56 ENST00000531264.1
MAS-related GPR, member X3
chr11_-_105010320 0.55 ENST00000532895.1
ENST00000530950.1
caspase recruitment domain family, member 18
chr6_-_107235331 0.37 ENST00000433965.1
ENST00000430094.1
RP1-60O19.1
chr17_+_45331184 0.36 ENST00000559488.1
ENST00000571680.1
ENST00000435993.2
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
chr3_+_177534653 0.36 ENST00000436078.1
RP11-91K9.1
chr5_+_140514782 0.31 ENST00000231134.5
protocadherin beta 5
chr19_+_49109990 0.25 ENST00000321762.1
sperm acrosome associated 4
chr13_-_81801115 0.24 ENST00000567258.1
long intergenic non-protein coding RNA 564
chr14_-_23292596 0.24 ENST00000554741.1
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr10_-_4285835 0.22 ENST00000454470.1
long intergenic non-protein coding RNA 702
chr1_+_229440129 0.21 ENST00000366688.3
S-phase response (cyclin related)
chrX_-_153141783 0.20 ENST00000458029.1
L1 cell adhesion molecule
chr14_+_94492674 0.19 ENST00000203664.5
ENST00000553723.1
OTU domain, ubiquitin aldehyde binding 2
chr10_-_4285923 0.17 ENST00000418372.1
ENST00000608792.1
long intergenic non-protein coding RNA 702
chr2_+_13677795 0.15 ENST00000434509.1
AC092635.1
chr12_-_66035922 0.15 ENST00000546198.1
ENST00000535315.1
ENST00000537298.1
RP11-230G5.2
chr14_+_75230011 0.14 ENST00000552421.1
ENST00000325680.7
ENST00000238571.3
YLP motif containing 1
chr1_+_28527070 0.14 ENST00000596102.1
AL353354.2
chr14_-_81425828 0.14 ENST00000555529.1
ENST00000556042.1
ENST00000556981.1
centrosomal protein 128kDa
chr16_-_31564881 0.13 ENST00000567765.1
CTD-2014E2.6
chr7_-_38969150 0.12 ENST00000418457.2
vacuolar protein sorting 41 homolog (S. cerevisiae)
chr6_-_133084580 0.12 ENST00000525270.1
ENST00000530536.1
ENST00000524919.1
vanin 2
chr3_+_127770455 0.12 ENST00000464451.1
Sec61 alpha 1 subunit (S. cerevisiae)
chr17_+_4853442 0.12 ENST00000522301.1
enolase 3 (beta, muscle)
chr18_+_63273310 0.11 ENST00000579862.1
RP11-775G23.1
chr10_-_94003003 0.11 ENST00000412050.4
cytoplasmic polyadenylation element binding protein 3
chr16_+_56672571 0.11 ENST00000290705.8
metallothionein 1A
chr6_+_106534192 0.10 ENST00000369091.2
ENST00000369096.4
PR domain containing 1, with ZNF domain
chr19_+_31658405 0.09 ENST00000589511.1
CTC-439O9.3
chr2_+_228735763 0.09 ENST00000373666.2
dynein assembly factor with WDR repeat domains 1
chr2_-_120124258 0.09 ENST00000409877.1
ENST00000409523.1
ENST00000409466.2
ENST00000414534.1
chromosome 2 open reading frame 76
chrX_+_54834004 0.09 ENST00000375068.1
melanoma antigen family D, 2
chr12_-_66036137 0.09 ENST00000539653.1
ENST00000544557.1
RP11-230G5.2
chr7_+_128349106 0.09 ENST00000485070.1
family with sequence similarity 71, member F1
chr6_-_107235378 0.09 ENST00000606430.1
RP1-60O19.1
chr4_-_186682716 0.09 ENST00000445343.1
sorbin and SH3 domain containing 2
chr6_-_88001706 0.08 ENST00000369576.2
gap junction protein, beta 7, 25kDa
chr1_-_153123345 0.08 ENST00000368748.4
small proline-rich protein 2G
chr5_+_40841410 0.08 ENST00000381677.3
caspase recruitment domain family, member 6
chr2_+_232135245 0.08 ENST00000446447.1
armadillo repeat containing 9
chr5_+_140729649 0.07 ENST00000523390.1
protocadherin gamma subfamily B, 1
chr11_+_61717279 0.07 ENST00000378043.4
bestrophin 1
chr5_+_140480083 0.07 ENST00000231130.2
protocadherin beta 3
chr7_+_117120017 0.07 ENST00000003084.6
ENST00000454343.1
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
chr11_+_61717336 0.07 ENST00000378042.3
bestrophin 1
chr2_+_110656005 0.07 ENST00000437679.2
LIM and senescent cell antigen-like domains 3
chr12_-_49581152 0.07 ENST00000550811.1
tubulin, alpha 1a
chrX_+_54834159 0.07 ENST00000375053.2
ENST00000347546.4
ENST00000375062.4
melanoma antigen family D, 2
chr18_+_29769978 0.07 ENST00000269202.6
ENST00000581447.1
meprin A, beta
chr14_+_38264418 0.06 ENST00000267368.7
ENST00000382320.3
tetratricopeptide repeat domain 6
chrX_-_19817869 0.06 ENST00000379698.4
SH3-domain kinase binding protein 1
chrX_-_52827141 0.06 ENST00000375511.3
SPANX family, member N5
chr2_+_113816215 0.06 ENST00000346807.3
interleukin 36 receptor antagonist
chr1_+_55464600 0.06 ENST00000371265.4
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr4_-_186696425 0.06 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
sorbin and SH3 domain containing 2
chr10_+_24497704 0.06 ENST00000376456.4
ENST00000458595.1
KIAA1217
chr7_-_107968999 0.06 ENST00000456431.1
neuronal cell adhesion molecule
chr5_+_140810132 0.05 ENST00000252085.3
protocadherin gamma subfamily A, 12
chr6_+_31895287 0.05 ENST00000447952.2
complement component 2
chr1_-_161337662 0.05 ENST00000367974.1
chromosome 1 open reading frame 192
chr15_+_54901540 0.05 ENST00000539562.2
unc-13 homolog C (C. elegans)
chr13_+_50570019 0.05 ENST00000442421.1
tripartite motif containing 13
chr12_-_10978957 0.05 ENST00000240619.2
taste receptor, type 2, member 10
chr16_-_58768177 0.05 ENST00000434819.2
ENST00000245206.5
glutamic-oxaloacetic transaminase 2, mitochondrial
chr15_+_54305101 0.05 ENST00000260323.11
ENST00000545554.1
ENST00000537900.1
unc-13 homolog C (C. elegans)
chr20_-_7921090 0.05 ENST00000378789.3
hydroxyacid oxidase (glycolate oxidase) 1
chr7_-_130080977 0.05 ENST00000223208.5
centrosomal protein 41kDa
chr12_-_4754318 0.05 ENST00000536414.1
A kinase (PRKA) anchor protein 3
chr12_-_39734783 0.05 ENST00000552961.1
kinesin family member 21A
chr7_+_117120106 0.04 ENST00000426809.1
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
chr4_-_186696636 0.04 ENST00000444771.1
sorbin and SH3 domain containing 2
chr1_-_206785789 0.04 ENST00000437518.1
ENST00000367114.3
eukaryotic translation initiation factor 2D
chr7_+_95171457 0.04 ENST00000601424.1
Protein LOC100996577
chr4_-_186734275 0.04 ENST00000456060.1
sorbin and SH3 domain containing 2
chr4_+_69313145 0.04 ENST00000305363.4
transmembrane protease, serine 11E
chr6_+_29424958 0.04 ENST00000377136.1
ENST00000377133.1
olfactory receptor, family 2, subfamily H, member 1
chr6_-_130543958 0.04 ENST00000437477.2
ENST00000439090.2
sterile alpha motif domain containing 3
chr6_+_31895254 0.04 ENST00000299367.5
ENST00000442278.2
complement component 2
chr6_+_53948328 0.04 ENST00000370876.2
muscular LMNA-interacting protein
chr16_-_28374829 0.04 ENST00000532254.1
nuclear pore complex interacting protein family, member B6
chr4_-_104021009 0.04 ENST00000509245.1
ENST00000296424.4
3-hydroxybutyrate dehydrogenase, type 2
chr4_-_186733363 0.04 ENST00000393523.2
ENST00000393528.3
ENST00000449407.2
sorbin and SH3 domain containing 2
chr9_-_95244781 0.03 ENST00000375544.3
ENST00000375543.1
ENST00000395538.3
ENST00000450139.2
asporin
chr10_+_90562487 0.03 ENST00000404743.4
lipase, family member M
chr17_+_40950900 0.03 ENST00000588527.1
cyclin N-terminal domain containing 1
chr4_-_987217 0.03 ENST00000361661.2
ENST00000398516.2
solute carrier family 26 (anion exchanger), member 1
chr11_+_35222629 0.03 ENST00000526553.1
CD44 molecule (Indian blood group)
chr2_-_158182410 0.03 ENST00000419116.2
ENST00000410096.1
ermin, ERM-like protein
chr6_-_49712123 0.03 ENST00000263045.4
cysteine-rich secretory protein 3
chr4_+_108910870 0.03 ENST00000403312.1
ENST00000603302.1
ENST00000309522.3
hydroxyacyl-CoA dehydrogenase
chr3_-_47950745 0.03 ENST00000429422.1
microtubule-associated protein 4
chr20_+_23420885 0.03 ENST00000246020.2
cystatin-like 1
chrX_+_144328348 0.03 ENST00000370493.3
SPANX family, member N1
chr2_-_231084617 0.03 ENST00000409815.2
SP110 nuclear body protein
chr6_+_72922505 0.03 ENST00000401910.3
regulating synaptic membrane exocytosis 1
chr1_-_59043166 0.03 ENST00000371225.2
tumor-associated calcium signal transducer 2
chr1_-_216978709 0.03 ENST00000360012.3
estrogen-related receptor gamma
chr14_+_23235886 0.02 ENST00000604262.1
ENST00000431881.2
ENST00000412791.1
ENST00000358043.5
oxidase (cytochrome c) assembly 1-like
chr4_-_186697044 0.02 ENST00000437304.2
sorbin and SH3 domain containing 2
chr5_+_125758813 0.02 ENST00000285689.3
ENST00000515200.1
GRAM domain containing 3
chr11_+_22689648 0.02 ENST00000278187.3
growth arrest-specific 2
chr6_+_72922590 0.02 ENST00000523963.1
regulating synaptic membrane exocytosis 1
chr20_-_30310656 0.02 ENST00000376055.4
BCL2-like 1
chr9_-_107361788 0.02 ENST00000374779.2
olfactory receptor, family 13, subfamily C, member 5
chr22_+_44319619 0.02 ENST00000216180.3
patatin-like phospholipase domain containing 3
chr3_+_111260856 0.02 ENST00000352690.4
CD96 molecule
chr5_+_150040403 0.02 ENST00000517768.1
ENST00000297130.4
myozenin 3
chr7_-_121944491 0.02 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZ family zinc finger 1
chr12_-_100378006 0.02 ENST00000547776.2
ENST00000329257.7
ENST00000547010.1
ankyrin repeat and sterile alpha motif domain containing 1B
chr6_+_54173227 0.02 ENST00000259782.4
ENST00000370864.3
tubulointerstitial nephritis antigen
chr4_-_186696515 0.02 ENST00000456596.1
ENST00000414724.1
sorbin and SH3 domain containing 2
chr20_-_30310693 0.02 ENST00000307677.4
ENST00000420653.1
BCL2-like 1
chr3_+_122399444 0.01 ENST00000474629.2
poly (ADP-ribose) polymerase family, member 14
chr3_+_140981456 0.01 ENST00000504264.1
acid phosphatase-like 2
chr4_-_987164 0.01 ENST00000398520.2
solute carrier family 26 (anion exchanger), member 1
chr20_-_30310336 0.01 ENST00000434194.1
ENST00000376062.2
BCL2-like 1
chr18_-_56985776 0.01 ENST00000587244.1
complexin 4
chr3_+_111260954 0.01 ENST00000283285.5
CD96 molecule
chr19_+_6887571 0.01 ENST00000250572.8
ENST00000381407.5
ENST00000312053.4
ENST00000450315.3
ENST00000381404.4
egf-like module containing, mucin-like, hormone receptor-like 1
chrX_-_119077695 0.01 ENST00000371410.3
NFKB activating protein
chr4_-_186696561 0.01 ENST00000445115.1
ENST00000451701.1
ENST00000457247.1
ENST00000435480.1
ENST00000425679.1
ENST00000457934.1
sorbin and SH3 domain containing 2
chr2_+_101437487 0.01 ENST00000427413.1
ENST00000542504.1
neuronal PAS domain protein 2
chr5_+_74011328 0.01 ENST00000513336.1
hexosaminidase B (beta polypeptide)
chr20_-_56286479 0.00 ENST00000265626.4
prostate transmembrane protein, androgen induced 1
chr16_-_8622226 0.00 ENST00000568335.1
transmembrane protein 114
chr4_-_103998060 0.00 ENST00000339611.4
solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
chr2_-_158182322 0.00 ENST00000420719.2
ENST00000409216.1
ermin, ERM-like protein
chr9_+_35161998 0.00 ENST00000396787.1
ENST00000378495.3
ENST00000378496.4
unc-13 homolog B (C. elegans)
chr13_+_76413852 0.00 ENST00000533809.2
LIM domain 7
chr17_-_17184605 0.00 ENST00000268717.5
COP9 signalosome subunit 3
chr4_-_104020968 0.00 ENST00000504285.1
3-hydroxybutyrate dehydrogenase, type 2
chr8_-_108510224 0.00 ENST00000517746.1
ENST00000297450.3
angiopoietin 1

Network of associatons between targets according to the STRING database.

First level regulatory network of BBX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0 0.1 GO:1900365 positive regulation of mRNA polyadenylation(GO:1900365)
0.0 0.6 GO:0050713 negative regulation of interleukin-1 beta secretion(GO:0050713)
0.0 0.1 GO:1990654 sebum secreting cell proliferation(GO:1990654)
0.0 0.2 GO:0000821 regulation of arginine metabolic process(GO:0000821) basic amino acid transmembrane transport(GO:1990822)
0.0 0.1 GO:0042144 vacuole fusion, non-autophagic(GO:0042144)
0.0 0.1 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
0.0 0.1 GO:1902161 positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161)
0.0 0.2 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.1 GO:0006106 fumarate metabolic process(GO:0006106) aspartate catabolic process(GO:0006533)
0.0 0.2 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.1 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.0 0.1 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.0 0.2 GO:0070294 renal sodium ion absorption(GO:0070294)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 0.1 GO:0044305 calyx of Held(GO:0044305)
0.0 0.1 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.1 GO:0033263 CORVET complex(GO:0033263)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.0 0.6 GO:0089720 caspase binding(GO:0089720)
0.0 0.1 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.0 0.2 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.1 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.0 0.2 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.2 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.1 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions