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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for BACH1_NFE2_NFE2L2
Z-value: 1.13
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Transcription factors associated with BACH1_NFE2_NFE2L2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000156273.11 | BTB domain and CNC homolog 1 | |
| ENSG00000123405.9 | nuclear factor, erythroid 2 | |
| ENSG00000116044.11 | nuclear factor, erythroid 2 like 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFE2L2 | hg19_v2_chr2_-_178129551_178129572 | -0.84 | 3.6e-02 | Click! |
| BACH1 | hg19_v2_chr21_+_30672433_30672464 | -0.56 | 2.5e-01 | Click! |
| NFE2 | hg19_v2_chr12_-_54691668_54691725 | -0.42 | 4.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of BACH1_NFE2_NFE2L2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 4.5 | GO:0002384 | hepatic immune response(GO:0002384) response to prolactin(GO:1990637) |
| 0.2 | 1.5 | GO:0051549 | positive regulation of keratinocyte migration(GO:0051549) |
| 0.1 | 1.3 | GO:0003373 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 0.0 | 1.3 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.1 | 0.9 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.1 | 0.8 | GO:0045229 | cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229) |
| 0.0 | 0.7 | GO:0097119 | postsynaptic density protein 95 clustering(GO:0097119) |
| 0.0 | 0.6 | GO:0005980 | glycogen catabolic process(GO:0005980) |
| 0.1 | 0.5 | GO:0044565 | dendritic cell proliferation(GO:0044565) |
| 0.1 | 0.4 | GO:1903660 | negative regulation of complement-dependent cytotoxicity(GO:1903660) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 4.5 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.0 | 2.5 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 0.9 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 0.7 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.1 | 0.6 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
| 0.0 | 0.6 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.0 | 0.5 | GO:0005838 | proteasome regulatory particle(GO:0005838) |
| 0.1 | 0.4 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) sperm plasma membrane(GO:0097524) |
| 0.0 | 0.4 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.0 | 0.4 | GO:0000145 | exocyst(GO:0000145) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 4.5 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.0 | 1.7 | GO:0005518 | collagen binding(GO:0005518) |
| 0.1 | 0.9 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.1 | 0.8 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.0 | 0.7 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 0.6 | GO:0004689 | phosphorylase kinase activity(GO:0004689) |
| 0.0 | 0.5 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.1 | 0.4 | GO:0002134 | pyrimidine nucleoside binding(GO:0001884) UTP binding(GO:0002134) sulfonylurea receptor binding(GO:0017098) pyrimidine ribonucleoside binding(GO:0032551) |
| 0.1 | 0.4 | GO:0036134 | thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134) |
| 0.0 | 0.4 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.5 | ST STAT3 PATHWAY | STAT3 Pathway |
| 0.0 | 1.8 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 0.4 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.0 | 0.1 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.6 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.1 | 2.1 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 1.8 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 1.7 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.0 | 1.3 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 1.1 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 0.6 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 0.5 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.0 | 0.4 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 0.4 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |