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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for ATF7
Z-value: 0.95
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Transcription factors associated with ATF7
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ATF7 | hg19_v2_chr12_-_54019755_54019804 | 0.77 | 7.5e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr18_+_76829385 Show fit | 0.75 |
ENST00000426216.2
ENST00000307671.7 ENST00000586672.1 ENST00000586722.1 |
ATPase, class II, type 9B |
|
| chr8_-_30013748 Show fit | 0.72 |
ENST00000607315.1
|
RP11-51J9.5 |
|
| chr18_+_76829441 Show fit | 0.70 |
ENST00000458297.2
|
ATPase, class II, type 9B |
|
| chr17_-_43210580 Show fit | 0.63 |
ENST00000538093.1
ENST00000590644.1 |
phospholipase C, delta 3 |
|
| chr2_+_171640291 Show fit | 0.61 |
ENST00000409885.1
|
glutamate-rich 2 |
|
| chr7_-_65958525 Show fit | 0.59 |
ENST00000450353.1
ENST00000412091.1 |
GS1-124K5.3 |
|
| chr19_-_50979981 Show fit | 0.57 |
ENST00000595790.1
ENST00000600100.1 |
family with sequence similarity 71, member E1 |
|
| chrX_+_48398053 Show fit | 0.54 |
ENST00000537536.1
ENST00000418627.1 |
TBC1 domain family, member 25 |
|
| chr6_-_27782548 Show fit | 0.53 |
ENST00000333151.3
|
histone cluster 1, H2aj |
|
| chr22_-_44258360 Show fit | 0.51 |
ENST00000330884.4
ENST00000249130.5 |
sulfotransferase family 4A, member 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ATF7
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | GO:0045332 | phospholipid translocation(GO:0045332) |
| 0.0 | 0.8 | GO:0060716 | labyrinthine layer blood vessel development(GO:0060716) |
| 0.0 | 0.8 | GO:0050650 | chondroitin sulfate proteoglycan biosynthetic process(GO:0050650) |
| 0.1 | 0.6 | GO:0002318 | myeloid progenitor cell differentiation(GO:0002318) |
| 0.1 | 0.5 | GO:0006669 | sphinganine-1-phosphate biosynthetic process(GO:0006669) |
| 0.0 | 0.5 | GO:1901096 | regulation of autophagosome maturation(GO:1901096) |
| 0.0 | 0.5 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.1 | 0.4 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
| 0.1 | 0.4 | GO:0043504 | mitochondrial DNA repair(GO:0043504) |
| 0.0 | 0.4 | GO:0002329 | pre-B cell differentiation(GO:0002329) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.8 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.0 | 0.4 | GO:0098563 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.0 | 0.3 | GO:0032021 | NELF complex(GO:0032021) |
| 0.0 | 0.3 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.0 | 0.3 | GO:0070187 | telosome(GO:0070187) |
| 0.0 | 0.3 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.1 | 0.2 | GO:0097124 | cyclin A2-CDK2 complex(GO:0097124) |
| 0.0 | 0.2 | GO:0071148 | TEAD-1-YAP complex(GO:0071148) |
| 0.0 | 0.2 | GO:0045323 | interleukin-1 receptor complex(GO:0045323) |
| 0.0 | 0.2 | GO:0044393 | microspike(GO:0044393) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.0 | 0.6 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.1 | 0.5 | GO:0050510 | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510) |
| 0.1 | 0.5 | GO:0017050 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
| 0.0 | 0.5 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.1 | 0.4 | GO:0010521 | telomerase inhibitor activity(GO:0010521) |
| 0.0 | 0.4 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.0 | 0.4 | GO:0009008 | DNA-methyltransferase activity(GO:0009008) |
| 0.0 | 0.4 | GO:0051880 | G-quadruplex DNA binding(GO:0051880) |
| 0.0 | 0.4 | GO:0008297 | single-stranded DNA exodeoxyribonuclease activity(GO:0008297) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 0.6 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 0.6 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.0 | 0.5 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.0 | 0.5 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 0.4 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.0 | 0.3 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 0.3 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.0 | 0.3 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |