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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for ATF2_ATF1_ATF3
Z-value: 1.36
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Transcription factors associated with ATF2_ATF1_ATF3
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000115966.12 | activating transcription factor 2 | |
| ENSG00000123268.4 | activating transcription factor 1 | |
| ENSG00000162772.12 | activating transcription factor 3 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ATF1 | hg19_v2_chr12_+_51158263_51158395 | 0.60 | 2.1e-01 | Click! |
| ATF2 | hg19_v2_chr2_-_176032843_176032941 | -0.11 | 8.4e-01 | Click! |
| ATF3 | hg19_v2_chr1_+_212782012_212782257 | -0.06 | 9.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ATF2_ATF1_ATF3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.7 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.0 | 2.0 | GO:0072600 | establishment of protein localization to Golgi(GO:0072600) |
| 0.5 | 1.6 | GO:0010845 | positive regulation of reciprocal meiotic recombination(GO:0010845) |
| 0.1 | 1.5 | GO:0010917 | negative regulation of mitochondrial membrane potential(GO:0010917) |
| 0.1 | 1.4 | GO:0003406 | retinal pigment epithelium development(GO:0003406) |
| 0.1 | 1.1 | GO:0070973 | protein localization to endoplasmic reticulum exit site(GO:0070973) |
| 0.1 | 1.1 | GO:1902412 | regulation of mitotic cytokinesis(GO:1902412) |
| 0.1 | 1.1 | GO:0007253 | cytoplasmic sequestering of NF-kappaB(GO:0007253) |
| 0.0 | 1.1 | GO:0039702 | viral budding via host ESCRT complex(GO:0039702) |
| 0.2 | 1.0 | GO:0009107 | lipoate biosynthetic process(GO:0009107) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.7 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
| 0.1 | 1.9 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.2 | 1.6 | GO:0033503 | HULC complex(GO:0033503) |
| 0.0 | 1.0 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 0.9 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 0.1 | 0.9 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 0.0 | 0.9 | GO:0071141 | SMAD protein complex(GO:0071141) |
| 0.3 | 0.8 | GO:0070685 | macropinocytic cup(GO:0070685) |
| 0.0 | 0.8 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.2 | 0.7 | GO:0031084 | BLOC-2 complex(GO:0031084) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.7 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.0 | 1.8 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 1.4 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 1.1 | GO:0008080 | N-acetyltransferase activity(GO:0008080) |
| 0.3 | 1.0 | GO:0070283 | lipoate synthase activity(GO:0016992) radical SAM enzyme activity(GO:0070283) |
| 0.0 | 1.0 | GO:0030159 | receptor signaling complex scaffold activity(GO:0030159) |
| 0.2 | 0.9 | GO:0035575 | histone demethylase activity (H4-K20 specific)(GO:0035575) |
| 0.2 | 0.9 | GO:0072320 | volume-sensitive chloride channel activity(GO:0072320) |
| 0.0 | 0.9 | GO:0017151 | DEAD/H-box RNA helicase binding(GO:0017151) |
| 0.0 | 0.9 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.8 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 1.3 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.0 | 1.1 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 1.1 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 1.0 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 0.9 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 0.9 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.0 | 0.8 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.0 | 0.7 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.0 | 0.7 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.0 | 1.1 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 0.9 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.0 | 0.9 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 0.8 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 0.8 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.0 | 0.7 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 0.7 | REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
| 0.0 | 0.7 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 0.6 | REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |