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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for AR_NR3C2

Z-value: 0.70

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Transcription factors associated with AR_NR3C2

Gene Symbol Gene ID Gene Info
AR
ENSG00000169083.11 androgen receptor
NR3C2
ENSG00000151623.10 nuclear receptor subfamily 3 group C member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR3C2hg19_v2_chr4_-_149363662_1493636880.483.4e-01Click!
ARhg19_v2_chrX_+_66764375_66764465-0.049.4e-01Click!

Activity profile of AR_NR3C2 motif

Sorted Z-values of AR_NR3C2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_31658349 0.93 ENST00000558844.1
KLF13
Kruppel-like factor 13
chr11_+_18287801 0.80 ENST00000532858.1
ENST00000405158.2
SAA1
serum amyloid A1
chr11_+_18287721 0.79 ENST00000356524.4
SAA1
serum amyloid A1
chr1_+_1846519 0.46 ENST00000378604.3
CALML6
calmodulin-like 6
chr19_-_42916499 0.43 ENST00000601189.1
ENST00000599211.1
LIPE
lipase, hormone-sensitive
chr16_+_56642041 0.42 ENST00000245185.5
MT2A
metallothionein 2A
chr12_+_66582919 0.36 ENST00000545837.1
ENST00000457197.2
IRAK3
interleukin-1 receptor-associated kinase 3
chr16_-_787728 0.34 ENST00000567403.1
ENST00000562421.1
NARFL
nuclear prelamin A recognition factor-like
chr17_-_79304150 0.34 ENST00000574093.1
TMEM105
transmembrane protein 105
chr2_-_166702601 0.33 ENST00000428888.1
AC009495.4
AC009495.4
chr16_+_56672571 0.31 ENST00000290705.8
MT1A
metallothionein 1A
chr18_+_47087390 0.30 ENST00000583083.1
LIPG
lipase, endothelial
chr3_+_125985620 0.30 ENST00000511512.1
ENST00000512435.1
RP11-71E19.1
RP11-71E19.1
chr12_-_122241812 0.28 ENST00000538335.1
AC084018.1
AC084018.1
chr12_-_53575120 0.27 ENST00000542115.1
CSAD
cysteine sulfinic acid decarboxylase
chr5_+_140186647 0.26 ENST00000512229.2
ENST00000356878.4
ENST00000530339.1
PCDHA4
protocadherin alpha 4
chr19_+_35741466 0.26 ENST00000599658.1
LSR
lipolysis stimulated lipoprotein receptor
chr16_+_56642489 0.25 ENST00000561491.1
MT2A
metallothionein 2A
chr3_-_119396193 0.22 ENST00000484810.1
ENST00000497116.1
ENST00000261070.2
COX17
COX17 cytochrome c oxidase copper chaperone
chr9_-_35563896 0.22 ENST00000399742.2
FAM166B
family with sequence similarity 166, member B
chr7_-_96654133 0.21 ENST00000486603.2
ENST00000222598.4
DLX5
distal-less homeobox 5
chr5_-_149792295 0.20 ENST00000518797.1
ENST00000524315.1
ENST00000009530.7
ENST00000377795.3
CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr2_-_242576864 0.19 ENST00000407315.1
THAP4
THAP domain containing 4
chr19_+_56187987 0.19 ENST00000411543.2
EPN1
epsin 1
chr18_+_47087055 0.19 ENST00000577628.1
LIPG
lipase, endothelial
chr16_-_787771 0.18 ENST00000568545.1
NARFL
nuclear prelamin A recognition factor-like
chr3_-_98235962 0.17 ENST00000513873.1
CLDND1
claudin domain containing 1
chr14_-_21493649 0.17 ENST00000553442.1
ENST00000555869.1
ENST00000556457.1
ENST00000397844.2
ENST00000554415.1
NDRG2
NDRG family member 2
chr1_-_1149506 0.16 ENST00000379236.3
TNFRSF4
tumor necrosis factor receptor superfamily, member 4
chr2_-_27435390 0.16 ENST00000428518.1
SLC5A6
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
chr8_-_145634731 0.15 ENST00000349769.3
CPSF1
cleavage and polyadenylation specific factor 1, 160kDa
chr9_+_131683174 0.14 ENST00000372592.3
ENST00000428610.1
PHYHD1
phytanoyl-CoA dioxygenase domain containing 1
chr2_-_75788428 0.14 ENST00000432649.1
EVA1A
eva-1 homolog A (C. elegans)
chr14_-_21493884 0.14 ENST00000556974.1
ENST00000554419.1
ENST00000298687.5
ENST00000397858.1
ENST00000360463.3
ENST00000350792.3
ENST00000397847.2
NDRG2
NDRG family member 2
chr12_+_122241928 0.13 ENST00000604567.1
ENST00000542440.1
SETD1B
SET domain containing 1B
chr17_+_79071365 0.13 ENST00000576756.1
BAIAP2
BAI1-associated protein 2
chr9_-_106087316 0.12 ENST00000411575.1
RP11-341A22.2
RP11-341A22.2
chr18_-_48346415 0.12 ENST00000431965.2
ENST00000436348.2
MRO
maestro
chr2_+_242577097 0.12 ENST00000419606.1
ENST00000474739.2
ENST00000396411.3
ENST00000425239.1
ENST00000400771.3
ENST00000430617.2
ATG4B
autophagy related 4B, cysteine peptidase
chr13_+_114462193 0.11 ENST00000375353.3
TMEM255B
transmembrane protein 255B
chr1_+_104104379 0.11 ENST00000435302.1
AMY2B
amylase, alpha 2B (pancreatic)
chr17_-_14140166 0.11 ENST00000420162.2
ENST00000431716.2
CDRT15
CMT1A duplicated region transcript 15
chr12_+_52203789 0.11 ENST00000599343.1
AC068987.1
HCG1997999; cDNA FLJ33996 fis, clone DFNES2008881
chr9_+_71650645 0.10 ENST00000396366.2
FXN
frataxin
chr3_+_52279737 0.10 ENST00000457351.2
PPM1M
protein phosphatase, Mg2+/Mn2+ dependent, 1M
chr8_-_72756667 0.10 ENST00000325509.4
MSC
musculin
chr19_+_35630344 0.09 ENST00000455515.2
FXYD1
FXYD domain containing ion transport regulator 1
chr2_+_242577027 0.09 ENST00000402096.1
ENST00000404914.3
ATG4B
autophagy related 4B, cysteine peptidase
chr1_-_27693349 0.09 ENST00000374040.3
ENST00000357582.2
ENST00000493901.1
MAP3K6
mitogen-activated protein kinase kinase kinase 6
chrX_+_2609317 0.09 ENST00000381187.3
ENST00000381184.1
CD99
CD99 molecule
chr2_-_27435634 0.09 ENST00000430186.1
SLC5A6
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
chr2_-_75788424 0.09 ENST00000410071.1
EVA1A
eva-1 homolog A (C. elegans)
chr19_-_8408139 0.09 ENST00000330915.3
ENST00000593649.1
ENST00000595639.1
KANK3
KN motif and ankyrin repeat domains 3
chr11_-_506739 0.08 ENST00000529306.1
ENST00000438658.2
ENST00000527485.1
ENST00000397615.2
ENST00000397614.1
RNH1
ribonuclease/angiogenin inhibitor 1
chr8_-_145634666 0.08 ENST00000531042.1
CPSF1
cleavage and polyadenylation specific factor 1, 160kDa
chr16_-_66584059 0.08 ENST00000417693.3
ENST00000544898.1
ENST00000569718.1
ENST00000527284.1
ENST00000299697.7
ENST00000451102.2
TK2
thymidine kinase 2, mitochondrial
chr19_-_14117074 0.08 ENST00000588885.1
ENST00000254325.4
RFX1
regulatory factor X, 1 (influences HLA class II expression)
chrX_-_6453159 0.08 ENST00000381089.3
ENST00000398729.1
VCX3A
variable charge, X-linked 3A
chrX_+_2609207 0.08 ENST00000381192.3
CD99
CD99 molecule
chr22_+_38054721 0.08 ENST00000215904.6
PDXP
pyridoxal (pyridoxine, vitamin B6) phosphatase
chr4_+_9174899 0.07 ENST00000432515.1
FAM90A26
family with sequence similarity 90, member A26
chr16_+_56716336 0.07 ENST00000394485.4
ENST00000562939.1
MT1X
metallothionein 1X
chr22_+_19939026 0.07 ENST00000406520.3
COMT
catechol-O-methyltransferase
chr12_-_106480587 0.07 ENST00000548902.1
NUAK1
NUAK family, SNF1-like kinase, 1
chr16_-_4852915 0.07 ENST00000322048.7
ROGDI
rogdi homolog (Drosophila)
chr16_-_67978016 0.07 ENST00000264005.5
LCAT
lecithin-cholesterol acyltransferase
chrX_+_2609356 0.06 ENST00000381180.3
ENST00000449611.1
CD99
CD99 molecule
chr2_+_27435179 0.06 ENST00000606999.1
ENST00000405489.3
ATRAID
all-trans retinoic acid-induced differentiation factor
chrX_+_8433376 0.06 ENST00000440654.2
ENST00000381029.4
VCX3B
variable charge, X-linked 3B
chr17_+_38498594 0.06 ENST00000394081.3
RARA
retinoic acid receptor, alpha
chr11_+_65851443 0.06 ENST00000533756.1
PACS1
phosphofurin acidic cluster sorting protein 1
chr8_+_91013577 0.06 ENST00000220764.2
DECR1
2,4-dienoyl CoA reductase 1, mitochondrial
chr19_-_14945933 0.06 ENST00000322301.3
OR7A5
olfactory receptor, family 7, subfamily A, member 5
chr4_-_8442438 0.05 ENST00000356406.5
ENST00000413009.2
ACOX3
acyl-CoA oxidase 3, pristanoyl
chr11_+_236540 0.05 ENST00000532097.1
PSMD13
proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
chr10_+_48359344 0.05 ENST00000412534.1
ENST00000444585.1
ZNF488
zinc finger protein 488
chr3_-_118864893 0.05 ENST00000354673.2
ENST00000425327.2
IGSF11
immunoglobulin superfamily, member 11
chr19_+_57874835 0.05 ENST00000543226.1
ENST00000596755.1
ENST00000282282.3
ENST00000597658.1
TRAPPC2P1
ZNF547
AC003002.4
trafficking protein particle complex 2 pseudogene 1
zinc finger protein 547
Uncharacterized protein
chr2_+_102953608 0.05 ENST00000311734.2
ENST00000409584.1
IL1RL1
interleukin 1 receptor-like 1
chr16_-_4852616 0.05 ENST00000591392.1
ENST00000587711.1
ROGDI
rogdi homolog (Drosophila)
chr12_-_56615693 0.04 ENST00000394013.2
ENST00000345093.4
ENST00000551711.1
ENST00000552656.1
RNF41
ring finger protein 41
chr19_+_8117881 0.04 ENST00000390669.3
CCL25
chemokine (C-C motif) ligand 25
chr8_+_9046503 0.04 ENST00000512942.2
RP11-10A14.5
RP11-10A14.5
chr22_+_18632666 0.04 ENST00000215794.7
USP18
ubiquitin specific peptidase 18
chr2_-_73298802 0.04 ENST00000411783.1
ENST00000410065.1
ENST00000442582.1
ENST00000272433.2
SFXN5
sideroflexin 5
chr6_-_26235206 0.04 ENST00000244534.5
HIST1H1D
histone cluster 1, H1d
chr11_-_5959840 0.03 ENST00000412903.1
TRIM5
tripartite motif containing 5
chr9_+_34957477 0.03 ENST00000544237.1
KIAA1045
KIAA1045
chr11_-_236326 0.03 ENST00000525237.1
ENST00000532956.1
ENST00000525319.1
ENST00000524564.1
ENST00000382743.4
SIRT3
sirtuin 3
chr17_-_65242063 0.03 ENST00000581159.1
HELZ
helicase with zinc finger
chr12_-_11002063 0.03 ENST00000544994.1
ENST00000228811.4
ENST00000540107.1
PRR4
proline rich 4 (lacrimal)
chr7_-_94285402 0.03 ENST00000428696.2
ENST00000445866.2
SGCE
sarcoglycan, epsilon
chr4_-_185395191 0.03 ENST00000510814.1
ENST00000507523.1
ENST00000506230.1
IRF2
interferon regulatory factor 2
chr3_-_134093738 0.03 ENST00000506107.1
AMOTL2
angiomotin like 2
chr3_-_118864861 0.03 ENST00000441144.2
IGSF11
immunoglobulin superfamily, member 11
chr17_-_16472483 0.03 ENST00000395824.1
ENST00000448349.2
ENST00000395825.3
ZNF287
zinc finger protein 287
chr10_-_375422 0.03 ENST00000434695.2
DIP2C
DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr1_-_159832438 0.03 ENST00000368100.1
VSIG8
V-set and immunoglobulin domain containing 8
chrX_-_24045303 0.03 ENST00000328046.8
KLHL15
kelch-like family member 15
chr15_+_42694573 0.03 ENST00000397200.4
ENST00000569827.1
CAPN3
calpain 3, (p94)
chr20_+_15177480 0.02 ENST00000402914.1
MACROD2
MACRO domain containing 2
chr1_-_10856694 0.02 ENST00000377022.3
ENST00000344008.5
CASZ1
castor zinc finger 1
chr3_-_24207039 0.02 ENST00000280696.5
THRB
thyroid hormone receptor, beta
chr7_+_150147711 0.02 ENST00000307271.3
GIMAP8
GTPase, IMAP family member 8
chr11_-_506316 0.02 ENST00000532055.1
ENST00000531540.1
RNH1
ribonuclease/angiogenin inhibitor 1
chr12_+_1099675 0.02 ENST00000545318.2
ERC1
ELKS/RAB6-interacting/CAST family member 1
chr4_+_8442496 0.02 ENST00000389737.4
ENST00000504134.1
TRMT44
tRNA methyltransferase 44 homolog (S. cerevisiae)
chr4_-_186347099 0.02 ENST00000505357.1
ENST00000264689.6
UFSP2
UFM1-specific peptidase 2
chr17_-_3794021 0.02 ENST00000381769.2
CAMKK1
calcium/calmodulin-dependent protein kinase kinase 1, alpha
chr5_-_173043591 0.02 ENST00000285908.5
ENST00000480951.1
ENST00000311086.4
BOD1
biorientation of chromosomes in cell division 1
chr1_-_209979465 0.02 ENST00000542854.1
IRF6
interferon regulatory factor 6
chr12_-_10251603 0.02 ENST00000457018.2
CLEC1A
C-type lectin domain family 1, member A
chr12_-_56615485 0.01 ENST00000549038.1
ENST00000552244.1
RNF41
ring finger protein 41
chr3_+_169491171 0.01 ENST00000356716.4
MYNN
myoneurin
chr19_-_45657028 0.01 ENST00000429338.1
ENST00000589776.1
NKPD1
NTPase, KAP family P-loop domain containing 1
chr17_-_19290117 0.01 ENST00000497081.2
MFAP4
microfibrillar-associated protein 4
chr1_+_61547405 0.01 ENST00000371189.4
NFIA
nuclear factor I/A
chr13_-_26452679 0.01 ENST00000596729.1
AL138815.2
Uncharacterized protein
chr19_+_8117636 0.00 ENST00000253451.4
ENST00000315626.4
CCL25
chemokine (C-C motif) ligand 25
chr15_-_28344439 0.00 ENST00000431101.1
ENST00000445578.1
ENST00000353809.5
ENST00000382996.2
ENST00000354638.3
OCA2
oculocutaneous albinism II
chr18_+_56530136 0.00 ENST00000591083.1
ZNF532
zinc finger protein 532
chr1_+_162335197 0.00 ENST00000431696.1
RP11-565P22.6
Uncharacterized protein
chr1_-_49242553 0.00 ENST00000371833.3
BEND5
BEN domain containing 5
chr4_-_69215699 0.00 ENST00000510746.1
ENST00000344157.4
ENST00000355665.3
YTHDC1
YTH domain containing 1
chr8_-_110615669 0.00 ENST00000533394.1
SYBU
syntabulin (syntaxin-interacting)
chr7_-_4877677 0.00 ENST00000538469.1
RADIL
Ras association and DIL domains

Network of associatons between targets according to the STRING database.

First level regulatory network of AR_NR3C2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.1 0.5 GO:0010983 regulation of high-density lipoprotein particle clearance(GO:0010982) positive regulation of high-density lipoprotein particle clearance(GO:0010983)
0.1 0.4 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.1 0.2 GO:0060166 olfactory pit development(GO:0060166)
0.1 0.3 GO:0042412 taurine biosynthetic process(GO:0042412)
0.1 0.9 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.1 0.4 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.0 0.3 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.0 0.2 GO:0015878 biotin transport(GO:0015878) pantothenate transmembrane transport(GO:0015887)
0.0 0.2 GO:0002906 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.0 1.6 GO:0050716 positive regulation of interleukin-1 secretion(GO:0050716)
0.0 0.5 GO:0032364 oxygen homeostasis(GO:0032364)
0.0 0.1 GO:0014707 branchiomeric skeletal muscle development(GO:0014707)
0.0 0.2 GO:0051697 protein delipidation(GO:0051697)
0.0 0.1 GO:0019230 metal incorporation into metallo-sulfur cluster(GO:0018282) iron incorporation into metallo-sulfur cluster(GO:0018283) proprioception(GO:0019230)
0.0 0.1 GO:0031247 actin rod assembly(GO:0031247)
0.0 0.3 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0 0.1 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.0 0.1 GO:0046092 deoxycytidine metabolic process(GO:0046092)
0.0 0.1 GO:0016036 cellular response to phosphate starvation(GO:0016036) positive regulation of sulfur amino acid metabolic process(GO:0031337) positive regulation of homocysteine metabolic process(GO:0050668)
0.0 0.2 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0 0.1 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.0 0.1 GO:0036018 response to erythropoietin(GO:0036017) cellular response to erythropoietin(GO:0036018)
0.0 0.2 GO:0010155 regulation of proton transport(GO:0010155)
0.0 0.0 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0097361 CIA complex(GO:0097361)
0.1 1.6 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.0 0.2 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 0.3 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.1 GO:0032311 angiogenin-PRI complex(GO:0032311)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.1 0.3 GO:0004782 sulfinoalanine decarboxylase activity(GO:0004782)
0.0 0.7 GO:0046870 cadmium ion binding(GO:0046870)
0.0 0.3 GO:0016530 metallochaperone activity(GO:0016530)
0.0 0.5 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 1.6 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.2 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.0 0.2 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.1 GO:0004556 alpha-amylase activity(GO:0004556)
0.0 0.1 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.0 0.1 GO:0002113 interleukin-33 binding(GO:0002113)
0.0 0.1 GO:0004137 deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797)
0.0 0.1 GO:0098519 phosphoserine phosphatase activity(GO:0004647) nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.0 0.1 GO:0016402 pristanoyl-CoA oxidase activity(GO:0016402)
0.0 0.1 GO:0034186 apolipoprotein A-I binding(GO:0034186)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.4 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.2 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism