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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for ALX1_ARX
Z-value: 0.46
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Transcription factors associated with ALX1_ARX
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ALX1 | hg19_v2_chr12_+_85673868_85673885 | -0.19 | 7.2e-01 | Click! |
| ARX | hg19_v2_chrX_-_25034065_25034088 | 0.05 | 9.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_86999516 Show fit | 0.43 |
ENST00000521564.1
|
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 |
|
| chr4_-_103940791 Show fit | 0.25 |
ENST00000510559.1
ENST00000394789.3 ENST00000296422.7 |
solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 |
|
| chr18_+_20714525 Show fit | 0.25 |
ENST00000400473.2
|
Cdk5 and Abl enzyme substrate 1 |
|
| chr5_+_36606700 Show fit | 0.22 |
ENST00000416645.2
|
solute carrier family 1 (glial high affinity glutamate transporter), member 3 |
|
| chr1_-_151148442 Show fit | 0.21 |
ENST00000441701.1
ENST00000416280.2 |
tropomodulin 4 (muscle) |
|
| chr6_-_107235331 Show fit | 0.19 |
ENST00000433965.1
ENST00000430094.1 |
RP1-60O19.1 |
|
| chr17_+_61151306 Show fit | 0.16 |
ENST00000580068.1
ENST00000580466.1 |
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 |
|
| chr19_-_58485895 Show fit | 0.16 |
ENST00000314391.3
|
chromosome 19 open reading frame 18 |
|
| chr9_-_71869642 Show fit | 0.15 |
ENST00000600472.1
|
Tight junction protein 2 (Zona occludens 2) isoform 1 variant; Uncharacterized protein |
|
| chr13_-_81801115 Show fit | 0.15 |
ENST00000567258.1
|
long intergenic non-protein coding RNA 564 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ALX1_ARX
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | GO:0007035 | vacuolar acidification(GO:0007035) |
| 0.0 | 0.2 | GO:0060809 | mesodermal to mesenchymal transition involved in gastrulation(GO:0060809) |
| 0.0 | 0.2 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.0 | 0.2 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 0.0 | 0.1 | GO:2000097 | negative regulation of lipoprotein oxidation(GO:0034443) regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 0.0 | 0.1 | GO:1900191 | biofilm formation(GO:0042710) single-species biofilm formation(GO:0044010) single-species biofilm formation in or on host organism(GO:0044407) regulation of single-species biofilm formation(GO:1900190) negative regulation of single-species biofilm formation(GO:1900191) regulation of single-species biofilm formation in or on host organism(GO:1900228) negative regulation of single-species biofilm formation in or on host organism(GO:1900229) |
| 0.0 | 0.1 | GO:2001190 | positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190) |
| 0.0 | 0.1 | GO:0021778 | oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780) |
| 0.0 | 0.1 | GO:0002384 | hepatic immune response(GO:0002384) |
| 0.0 | 0.1 | GO:0061300 | cerebellum vasculature development(GO:0061300) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | GO:0033179 | proton-transporting V-type ATPase, V0 domain(GO:0033179) |
| 0.0 | 0.1 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.0 | 0.1 | GO:0042720 | mitochondrial inner membrane peptidase complex(GO:0042720) |
| 0.0 | 0.1 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.0 | 0.0 | GO:1990032 | parallel fiber(GO:1990032) |
| 0.0 | 0.0 | GO:0034271 | phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.0 | 0.3 | GO:0015385 | sodium:proton antiporter activity(GO:0015385) |
| 0.0 | 0.2 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.0 | 0.1 | GO:0070119 | ciliary neurotrophic factor binding(GO:0070119) |
| 0.0 | 0.1 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
| 0.0 | 0.1 | GO:0005477 | pyruvate secondary active transmembrane transporter activity(GO:0005477) |
| 0.0 | 0.1 | GO:0050115 | myosin-light-chain-phosphatase activity(GO:0050115) |
| 0.0 | 0.0 | GO:0017098 | sulfonylurea receptor binding(GO:0017098) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |