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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for AIRE

Z-value: 0.32

Motif logo

Transcription factors associated with AIRE

Gene Symbol Gene ID Gene Info
ENSG00000160224.12 autoimmune regulator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
AIREhg19_v2_chr21_+_45705752_457057670.059.3e-01Click!

Activity profile of AIRE motif

Sorted Z-values of AIRE motif

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_44637526 0.39 ENST00000372330.3
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr13_-_30160925 0.23 ENST00000450494.1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr15_+_45938079 0.17 ENST00000561493.1
sulfide quinone reductase-like (yeast)
chr19_+_16607122 0.17 ENST00000221671.3
ENST00000594035.1
ENST00000599550.1
ENST00000594813.1
chromosome 19 open reading frame 44
chr16_+_56672571 0.17 ENST00000290705.8
metallothionein 1A
chr12_-_59175485 0.16 ENST00000550678.1
ENST00000552201.1
RP11-767I20.1
chr19_-_36643329 0.15 ENST00000589154.1
cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
chr11_-_327537 0.14 ENST00000602735.1
interferon induced transmembrane protein 3
chr7_+_76101379 0.14 ENST00000429179.1
deltex homolog 2 (Drosophila)
chr18_+_39739223 0.14 ENST00000601948.1
long intergenic non-protein coding RNA 907
chr11_+_107650219 0.14 ENST00000398067.1
Uncharacterized protein
chr1_+_96208646 0.13 ENST00000603401.1
RP11-286B14.2
chr12_+_75874580 0.12 ENST00000456650.3
GLI pathogenesis-related 1
chr1_+_165864821 0.11 ENST00000470820.1
uridine-cytidine kinase 2
chr12_+_55248289 0.11 ENST00000308796.6
mucin-like 1
chr19_-_48753028 0.11 ENST00000522431.1
caspase recruitment domain family, member 8
chr6_+_26104104 0.11 ENST00000377803.2
histone cluster 1, H4c
chr10_-_75682535 0.10 ENST00000409178.1
chromosome 10 open reading frame 55
chr5_-_38845812 0.09 ENST00000513480.1
ENST00000512519.1
CTD-2127H9.1
chrM_+_8366 0.09 ENST00000361851.1
mitochondrially encoded ATP synthase 8
chr11_+_64794875 0.09 ENST00000377244.3
ENST00000534637.1
ENST00000524831.1
sorting nexin 15
chr11_-_85376121 0.09 ENST00000527447.1
CREB/ATF bZIP transcription factor
chr6_+_116937636 0.08 ENST00000368581.4
ENST00000229554.5
ENST00000368580.4
radial spoke head 4 homolog A (Chlamydomonas)
chr11_+_64794991 0.08 ENST00000352068.5
ENST00000525648.1
sorting nexin 15
chr8_-_145652336 0.08 ENST00000529182.1
ENST00000526054.1
vacuolar protein sorting 28 homolog (S. cerevisiae)
chr1_+_79115503 0.08 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
interferon-induced protein 44
chr19_-_10491234 0.08 ENST00000524462.1
ENST00000531836.1
ENST00000525621.1
tyrosine kinase 2
chr19_-_10491130 0.08 ENST00000530829.1
ENST00000529370.1
tyrosine kinase 2
chr19_-_4902877 0.08 ENST00000381781.2
arrestin domain containing 5
chrM_+_14741 0.07 ENST00000361789.2
mitochondrially encoded cytochrome b
chr6_+_22221010 0.07 ENST00000567753.1
RP11-524C21.2
chrM_+_7586 0.07 ENST00000361739.1
mitochondrially encoded cytochrome c oxidase II
chr12_+_12202785 0.07 ENST00000586576.1
ENST00000464885.2
BCL2-like 14 (apoptosis facilitator)
chr10_-_106240032 0.07 ENST00000447860.1
RP11-127O4.3
chr11_-_26744908 0.06 ENST00000533617.1
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
chr4_+_69917078 0.06 ENST00000502942.1
UDP glucuronosyltransferase 2 family, polypeptide B7
chr17_+_77030267 0.06 ENST00000581774.1
C1q and tumor necrosis factor related protein 1
chr16_+_75182376 0.06 ENST00000570010.1
ENST00000568079.1
ENST00000464850.1
ENST00000332307.4
ENST00000393430.2
ZFP1 zinc finger protein
chr4_-_57524061 0.06 ENST00000508121.1
HOP homeobox
chr8_+_128748308 0.06 ENST00000377970.2
v-myc avian myelocytomatosis viral oncogene homolog
chr8_+_104384616 0.06 ENST00000520337.1
collagen triple helix repeat containing 1
chr1_-_243326612 0.06 ENST00000492145.1
ENST00000490813.1
ENST00000464936.1
centrosomal protein 170kDa
chr14_-_24912047 0.06 ENST00000553930.1
short chain dehydrogenase/reductase family 39U, member 1
chr2_+_38177575 0.05 ENST00000407257.1
ENST00000417700.2
ENST00000234195.3
ENST00000442857.1
regulator of microtubule dynamics 2
chr7_+_20686946 0.05 ENST00000443026.2
ENST00000406935.1
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr16_+_446713 0.05 ENST00000397722.1
ENST00000454619.1
NME/NM23 nucleoside diphosphate kinase 4
chr19_-_2085323 0.05 ENST00000591638.1
MOB kinase activator 3A
chr16_-_28503327 0.05 ENST00000535392.1
ENST00000395653.4
ceroid-lipofuscinosis, neuronal 3
chr13_+_111893533 0.05 ENST00000478679.1
Rho guanine nucleotide exchange factor (GEF) 7
chr17_-_295730 0.05 ENST00000329099.4
family with sequence similarity 101, member B
chr16_+_57126428 0.05 ENST00000290776.8
copine II
chr3_-_49466686 0.05 ENST00000273598.3
ENST00000436744.2
nicolin 1
chr12_+_12224331 0.05 ENST00000396367.1
ENST00000266434.4
ENST00000396369.1
BCL2-like 14 (apoptosis facilitator)
chr16_-_71518504 0.05 ENST00000565100.2
zinc finger protein 19
chr19_-_23869970 0.05 ENST00000601010.1
zinc finger protein 675
chr9_-_104198042 0.05 ENST00000374855.4
aldolase B, fructose-bisphosphate
chr21_+_39644214 0.05 ENST00000438657.1
potassium inwardly-rectifying channel, subfamily J, member 15
chr2_-_225811747 0.05 ENST00000409592.3
dedicator of cytokinesis 10
chr21_+_39644305 0.05 ENST00000398930.1
potassium inwardly-rectifying channel, subfamily J, member 15
chr16_-_31147020 0.04 ENST00000568261.1
ENST00000567797.1
ENST00000317508.6
protease, serine, 8
chr19_-_48753064 0.04 ENST00000520153.1
ENST00000357778.5
ENST00000520015.1
caspase recruitment domain family, member 8
chr12_-_113772835 0.04 ENST00000552014.1
ENST00000548186.1
ENST00000202831.3
ENST00000549181.1
solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
chr7_-_36764004 0.04 ENST00000431169.1
acyloxyacyl hydrolase (neutrophil)
chr18_-_56985776 0.04 ENST00000587244.1
complexin 4
chr6_+_155443048 0.04 ENST00000535583.1
T-cell lymphoma invasion and metastasis 2
chr5_+_122181279 0.04 ENST00000395451.4
ENST00000506996.1
sorting nexin 24
chr7_+_80255472 0.04 ENST00000428497.1
CD36 molecule (thrombospondin receptor)
chr5_+_140625147 0.04 ENST00000231173.3
protocadherin beta 15
chr1_+_40840320 0.04 ENST00000372708.1
small ArfGAP2
chr21_+_39644172 0.04 ENST00000398932.1
potassium inwardly-rectifying channel, subfamily J, member 15
chr11_+_94038759 0.04 ENST00000440961.2
ENST00000328458.4
folate receptor 4, delta (putative)
chr4_-_120243545 0.04 ENST00000274024.3
fatty acid binding protein 2, intestinal
chr16_+_57126482 0.04 ENST00000537605.1
ENST00000535318.2
copine II
chr1_+_36038971 0.04 ENST00000373235.3
transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)
chr3_-_19975665 0.04 ENST00000295824.9
ENST00000389256.4
EF-hand domain family, member B
chr12_-_11139511 0.04 ENST00000506868.1
taste receptor, type 2, member 50
chr8_-_16043780 0.04 ENST00000445506.2
macrophage scavenger receptor 1
chr21_+_30502806 0.04 ENST00000399928.1
ENST00000399926.1
MAP3K7 C-terminal like
chr9_-_70178815 0.04 ENST00000377420.1
forkhead box D4-like 5
chr21_+_39644395 0.04 ENST00000398934.1
potassium inwardly-rectifying channel, subfamily J, member 15
chrM_+_12331 0.04 ENST00000361567.2
mitochondrially encoded NADH dehydrogenase 5
chr4_+_1385340 0.04 ENST00000324803.4
cysteine-rich PAK1 inhibitor
chr10_-_101841588 0.03 ENST00000370418.3
carboxypeptidase N, polypeptide 1
chrX_+_70503433 0.03 ENST00000276079.8
ENST00000373856.3
ENST00000373841.1
ENST00000420903.1
non-POU domain containing, octamer-binding
chr10_+_115511213 0.03 ENST00000361048.1
pleckstrin homology domain containing, family S member 1
chr16_-_56223480 0.03 ENST00000565155.1
RP11-461O7.1
chr19_-_47249679 0.03 ENST00000263280.6
striatin, calmodulin binding protein 4
chr13_+_50570019 0.03 ENST00000442421.1
tripartite motif containing 13
chr1_-_152297679 0.03 ENST00000368799.1
filaggrin
chr11_-_8954491 0.03 ENST00000526227.1
ENST00000525780.1
ENST00000326053.5
chromosome 11 open reading frame 16
chr3_+_140981456 0.03 ENST00000504264.1
acid phosphatase-like 2
chrM_+_4431 0.03 ENST00000361453.3
mitochondrially encoded NADH dehydrogenase 2
chrM_-_14670 0.03 ENST00000361681.2
mitochondrially encoded NADH dehydrogenase 6
chr9_+_42717234 0.03 ENST00000377590.1
forkhead box D4-like 2
chr13_-_46756351 0.03 ENST00000323076.2
lymphocyte cytosolic protein 1 (L-plastin)
chr19_+_45418067 0.03 ENST00000589078.1
ENST00000586638.1
apolipoprotein C-I
chr7_-_36764142 0.03 ENST00000258749.5
ENST00000535891.1
acyloxyacyl hydrolase (neutrophil)
chr9_+_117904097 0.03 ENST00000374016.1
deleted in esophageal cancer 1
chr10_-_46030841 0.03 ENST00000453424.2
membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
chr1_-_154600421 0.03 ENST00000368471.3
ENST00000292205.5
adenosine deaminase, RNA-specific
chr18_+_39766626 0.03 ENST00000593234.1
ENST00000585627.1
ENST00000591199.1
ENST00000586990.1
ENST00000593051.1
ENST00000593316.1
ENST00000591381.1
ENST00000585639.1
ENST00000589068.1
long intergenic non-protein coding RNA 907
chr19_-_48752812 0.03 ENST00000359009.4
caspase recruitment domain family, member 8
chr9_-_70429731 0.03 ENST00000377413.1
forkhead box D4-like 4
chr15_-_99789736 0.03 ENST00000560235.1
ENST00000394132.2
ENST00000560860.1
ENST00000558078.1
ENST00000394136.1
ENST00000262074.4
ENST00000558613.1
ENST00000394130.1
ENST00000560772.1
tetratricopeptide repeat domain 23
chr2_+_1417228 0.03 ENST00000382269.3
ENST00000337415.3
ENST00000345913.4
ENST00000346956.3
ENST00000349624.3
ENST00000539820.1
ENST00000329066.4
ENST00000382201.3
thyroid peroxidase
chr19_-_48753104 0.03 ENST00000447740.2
caspase recruitment domain family, member 8
chr14_-_24911971 0.02 ENST00000555365.1
ENST00000399395.3
short chain dehydrogenase/reductase family 39U, member 1
chr12_+_4758264 0.02 ENST00000266544.5
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
chr9_-_79267432 0.02 ENST00000424866.1
prune homolog 2 (Drosophila)
chr11_+_6947647 0.02 ENST00000278319.5
zinc finger protein 215
chr3_+_189507460 0.02 ENST00000434928.1
tumor protein p63
chr10_-_69597810 0.02 ENST00000483798.2
DnaJ (Hsp40) homolog, subfamily C, member 12
chr22_+_36649170 0.02 ENST00000438034.1
ENST00000427990.1
ENST00000347595.7
ENST00000397279.4
ENST00000433768.1
ENST00000440669.2
apolipoprotein L, 1
chr19_-_59084922 0.02 ENST00000215057.2
ENST00000599369.1
myeloid zinc finger 1
chr19_-_16606988 0.02 ENST00000269881.3
calreticulin 3
chr6_-_127663543 0.02 ENST00000531582.1
enoyl CoA hydratase domain containing 1
chr16_-_31146961 0.02 ENST00000567531.1
protease, serine, 8
chr5_+_667759 0.02 ENST00000594226.1
Uncharacterized protein
chr9_-_4666421 0.02 ENST00000381895.5
spermatogenesis associated 6-like
chr17_+_7210294 0.02 ENST00000336452.7
eukaryotic translation initiation factor 5A
chr17_+_41857793 0.02 ENST00000449302.3
chromosome 17 open reading frame 105
chr8_+_24241789 0.02 ENST00000256412.4
ENST00000538205.1
ADAM-like, decysin 1
chr2_-_166060571 0.02 ENST00000360093.3
sodium channel, voltage-gated, type III, alpha subunit
chr10_+_82300575 0.02 ENST00000313455.4
SH2 domain containing 4B
chr6_+_118869452 0.02 ENST00000357525.5
phospholamban
chr2_+_179316163 0.02 ENST00000409117.3
deafness, autosomal recessive 59
chr1_+_241815577 0.02 ENST00000366552.2
ENST00000437684.2
WD repeat domain 64
chr16_-_29499154 0.02 ENST00000354563.5
Uncharacterized protein
chr9_+_100615536 0.02 ENST00000375123.3
forkhead box E1 (thyroid transcription factor 2)
chr9_-_113761720 0.02 ENST00000541779.1
ENST00000374430.2
lysophosphatidic acid receptor 1
chr2_+_207804278 0.02 ENST00000272852.3
carboxypeptidase O
chrX_-_139866723 0.02 ENST00000370532.2
cerebellar degeneration-related protein 1, 34kDa
chrM_+_5824 0.02 ENST00000361624.2
mitochondrially encoded cytochrome c oxidase I
chr12_-_6579833 0.02 ENST00000396308.3
vesicle-associated membrane protein 1 (synaptobrevin 1)
chr4_-_88450612 0.02 ENST00000418378.1
ENST00000282470.6
SPARC-like 1 (hevin)
chrX_-_153191674 0.02 ENST00000350060.5
ENST00000370016.1
Rho GTPase activating protein 4
chr7_-_87936195 0.02 ENST00000414498.1
ENST00000301959.5
ENST00000380079.4
STEAP family member 4
chr14_-_75330537 0.01 ENST00000556084.2
ENST00000556489.2
ENST00000445876.1
prospero homeobox 2
chr1_-_167883327 0.01 ENST00000476818.2
ENST00000367851.4
ENST00000367848.1
adenylate cyclase 10 (soluble)
chr4_-_66536057 0.01 ENST00000273854.3
EPH receptor A5
chr6_-_33266687 0.01 ENST00000444031.2
ral guanine nucleotide dissociation stimulator-like 2
chr11_+_35211511 0.01 ENST00000524922.1
CD44 molecule (Indian blood group)
chr7_-_149194843 0.01 ENST00000458143.2
ENST00000340622.3
zinc finger protein 746
chr9_+_71357171 0.01 ENST00000440050.1
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
chr2_-_166060552 0.01 ENST00000283254.7
ENST00000453007.1
sodium channel, voltage-gated, type III, alpha subunit
chr6_-_32806506 0.01 ENST00000374897.2
ENST00000452392.2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Uncharacterized protein
chr22_-_32767017 0.01 ENST00000400234.1
RFPL3 antisense
chr6_-_149806105 0.01 ENST00000389942.5
ENST00000416573.2
ENST00000542614.1
ENST00000409806.3
zinc finger CCCH-type containing 12D
chr14_-_65409438 0.01 ENST00000557049.1
glutathione peroxidase 2 (gastrointestinal)
chr11_+_45376922 0.01 ENST00000524410.1
ENST00000524488.1
ENST00000524565.1
RP11-430H10.1
chr10_+_127661942 0.01 ENST00000417114.1
ENST00000445510.1
ENST00000368691.1
fibronectin type III and ankyrin repeat domains 1
chr1_+_207669573 0.01 ENST00000400960.2
ENST00000534202.1
complement component (3b/4b) receptor 1 (Knops blood group)
chr7_-_15601595 0.01 ENST00000342526.3
alkylglycerol monooxygenase
chrX_-_153191708 0.01 ENST00000393721.1
ENST00000370028.3
Rho GTPase activating protein 4
chr6_+_36839616 0.01 ENST00000359359.2
ENST00000510325.2
chromosome 6 open reading frame 89
chr1_+_207669613 0.01 ENST00000367049.4
ENST00000529814.1
complement component (3b/4b) receptor 1 (Knops blood group)
chr12_+_7282795 0.01 ENST00000266546.6
calsyntenin 3
chr3_-_123710199 0.01 ENST00000184183.4
rhophilin associated tail protein 1
chr17_+_34171081 0.01 ENST00000585577.1
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
chr4_-_16085657 0.01 ENST00000543373.1
prominin 1
chr15_+_59910132 0.01 ENST00000559200.1
glucosaminyl (N-acetyl) transferase 3, mucin type
chr12_+_12223867 0.01 ENST00000308721.5
BCL2-like 14 (apoptosis facilitator)
chr2_-_127977654 0.01 ENST00000409327.1
cytochrome P450, family 27, subfamily C, polypeptide 1
chr7_-_137028534 0.01 ENST00000348225.2
pleiotrophin
chr7_+_142374104 0.01 ENST00000604952.1
MT-RNR2-like 6
chr8_-_7220490 0.01 ENST00000400078.2
zinc finger protein 705G
chr20_-_33735070 0.01 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
ER degradation enhancer, mannosidase alpha-like 2
chr21_-_44495919 0.01 ENST00000398158.1
cystathionine-beta-synthase
chr2_+_234686976 0.01 ENST00000389758.3
maestro heat-like repeat family member 2A
chr12_-_64784471 0.01 ENST00000333722.5
chromosome 12 open reading frame 56
chr10_-_81270678 0.01 ENST00000538322.1
Uncharacterized protein
chr6_-_33864684 0.00 ENST00000506222.2
ENST00000533304.1
long intergenic non-protein coding RNA 1016
chr2_-_198540719 0.00 ENST00000295049.4
raftlin family member 2
chr12_+_20963647 0.00 ENST00000381545.3
solute carrier organic anion transporter family, member 1B3
chr4_-_186696425 0.00 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
sorbin and SH3 domain containing 2
chr2_+_166150541 0.00 ENST00000283256.6
sodium channel, voltage-gated, type II, alpha subunit
chr12_+_12202774 0.00 ENST00000589718.1
BCL2-like 14 (apoptosis facilitator)
chr21_-_44495964 0.00 ENST00000398168.1
ENST00000398165.3
cystathionine-beta-synthase
chr15_-_81202118 0.00 ENST00000560560.1
Uncharacterized protein
chr4_-_120222076 0.00 ENST00000504110.1
chromosome 4 open reading frame 3
chr8_-_141774467 0.00 ENST00000520151.1
ENST00000519024.1
ENST00000519465.1
protein tyrosine kinase 2
chr10_-_46030787 0.00 ENST00000395769.2
membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
chr12_-_75603482 0.00 ENST00000341669.3
ENST00000298972.1
ENST00000350228.2
potassium voltage-gated channel, Shaw-related subfamily, member 2
chr5_-_77844974 0.00 ENST00000515007.2
lipoma HMGIC fusion partner-like 2
chr11_+_327171 0.00 ENST00000534483.1
ENST00000524824.1
ENST00000531076.1
RP11-326C3.12

Network of associatons between targets according to the STRING database.

First level regulatory network of AIRE

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0051549 positive regulation of keratinocyte migration(GO:0051549)
0.0 0.1 GO:0046035 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
0.0 0.2 GO:1903826 arginine transmembrane transport(GO:1903826)
0.0 0.1 GO:2000397 regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
0.0 0.1 GO:0090096 regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096)
0.0 0.1 GO:0048749 compound eye development(GO:0048749)
0.0 0.1 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.0 0.2 GO:0050713 negative regulation of interleukin-1 beta secretion(GO:0050713)
0.0 0.0 GO:0030070 insulin processing(GO:0030070)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0072559 NLRP3 inflammasome complex(GO:0072559)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0032089 NACHT domain binding(GO:0032089)
0.0 0.2 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.0 0.2 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.1 GO:0004849 uridine kinase activity(GO:0004849)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix