ISMARA results: AHR

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NHBE cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for AHR_ARNT2

Z-value: 0.50

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Transcription factors associated with AHR_ARNT2

Gene Symbol	Gene ID	Gene Info
AHR Ensembl NCBI GeneCards UniProt NextProt	ENSG00000106546.8	aryl hydrocarbon receptor
ARNT2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000172379.14	aryl hydrocarbon receptor nuclear translocator 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
AHR	hg19_v2_chr7_+_17338239_17338262	-0.60	2.0e-01	Click!
ARNT2	hg19_v2_chr15_+_80733570_80733659	-0.47	3.5e-01	Click!

Activity profile of AHR_ARNT2 motif

Sorted Z-values of AHR_ARNT2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr9_+_96928516 Show fit	0.20	ENST00000602703.1	RP11-2B6.3 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP11-2B6.3
chr3_-_156534754 Show fit	0.19	ENST00000472943.1 ENST00000473352.1	LINC00886 Ensembl NCBI GeneCards UniProt NextProt Show fit	long intergenic non-protein coding RNA 886
chr3_-_160823158 Show fit	0.17	ENST00000392779.2 ENST00000392780.1 ENST00000494173.1	B3GALNT1 Ensembl NCBI GeneCards UniProt NextProt Show fit	beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
chr5_+_151151471 Show fit	0.16	ENST00000394123.3 ENST00000543466.1	G3BP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	GTPase activating protein (SH3 domain) binding protein 1
chr5_+_151151504 Show fit	0.15	ENST00000356245.3 ENST00000507878.2	G3BP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	GTPase activating protein (SH3 domain) binding protein 1
chr2_+_219575543 Show fit	0.15	ENST00000457313.1 ENST00000415717.1 ENST00000392102.1	TTLL4 Ensembl NCBI GeneCards UniProt NextProt Show fit	tubulin tyrosine ligase-like family, member 4
chr2_-_214017151 Show fit	0.15	ENST00000452786.1	IKZF2 Ensembl NCBI GeneCards UniProt NextProt Show fit	IKAROS family zinc finger 2 (Helios)
chr22_-_36424458 Show fit	0.14	ENST00000438146.2	RBFOX2 Ensembl NCBI GeneCards UniProt NextProt Show fit	RNA binding protein, fox-1 homolog (C. elegans) 2
chr5_-_133340326 Show fit	0.14	ENST00000425992.1 ENST00000395044.3 ENST00000395047.2	VDAC1 Ensembl NCBI GeneCards UniProt NextProt Show fit	voltage-dependent anion channel 1
chr6_-_36355513 Show fit	0.14	ENST00000340181.4 ENST00000373737.4	ETV7 Ensembl NCBI GeneCards UniProt NextProt Show fit	ets variant 7

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of AHR_ARNT2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:2000349	regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) negative regulation of osteoclast proliferation(GO:0090291) negative regulation of CD40 signaling pathway(GO:2000349)
0.1	0.3	GO:0003068	age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571)
0.0	0.3	GO:0018095	protein polyglutamylation(GO:0018095)
0.0	0.3	GO:0009312	oligosaccharide biosynthetic process(GO:0009312)
0.1	0.2	GO:0003072	regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072)
0.0	0.2	GO:0006597	spermine biosynthetic process(GO:0006597)
0.0	0.2	GO:0006050	mannosamine metabolic process(GO:0006050) N-acetylmannosamine metabolic process(GO:0006051)
0.0	0.2	GO:0070541	response to platinum ion(GO:0070541)
0.0	0.2	GO:0021834	chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration(GO:0021834)
0.0	0.2	GO:1901857	positive regulation of cellular respiration(GO:1901857)

Showing 1 to 10 of 136 entries

Gene overrepresentation in cellular_component category:

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Total log-likelihood	Term	Description
0.3	GO:0033202	Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.2	GO:0000408	EKC/KEOPS complex(GO:0000408)
0.2	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.2	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.1	GO:0042565	RNA nuclear export complex(GO:0042565)
0.1	GO:0009346	citrate lyase complex(GO:0009346)
0.1	GO:0043511	inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.1	GO:0070826	paraferritin complex(GO:0070826)
0.1	GO:0005889	hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.1	GO:0097059	CNTFR-CLCF1 complex(GO:0097059)

Showing 1 to 10 of 29 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0047273	galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273)
0.0	0.3	GO:0070740	tubulin-glutamic acid ligase activity(GO:0070740)
0.0	0.3	GO:0061578	Lys63-specific deubiquitinase activity(GO:0061578)
0.1	0.2	GO:0016768	spermine synthase activity(GO:0016768)
0.0	0.2	GO:0045127	N-acetylglucosamine kinase activity(GO:0045127)
0.0	0.2	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.2	GO:1990050	phosphatidic acid transporter activity(GO:1990050)
0.0	0.2	GO:0004325	ferrochelatase activity(GO:0004325)
0.0	0.2	GO:0051022	GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0	0.2	GO:0004784	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)

Showing 1 to 10 of 85 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.0	PID REELIN PATHWAY	Reelin signaling pathway

Showing 1 to 1 of 1 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
0.4	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.2	REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	Genes involved in Sema3A PAK dependent Axon repulsion
0.1	REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6	Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.1	REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G	Genes involved in Vif-mediated degradation of APOBEC3G
0.0	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion

Showing 1 to 5 of 5 entries

Results for AHR_ARNT2

Z-value: 0.50

Motif logo

Transcription factors associated with AHR_ARNT2

Activity-expression correlation:

Activity profile of AHR_ARNT2 motif

Sorted Z-values of AHR_ARNT2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of AHR_ARNT2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: