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GSE58827: Dynamics of the Mouse Liver
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Results for Zbtb33_Chd2
Z-value: 3.40
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Transcription factors associated with Zbtb33_Chd2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Chd2 | mm39_v1_chr7_-_73191484_73191503 | 0.81 | 1.8e-09 | Click! |
| Zbtb33 | mm39_v1_chrX_+_37278636_37278722 | 0.69 | 3.1e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Zbtb33_Chd2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 24.8 | GO:0000398 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 1.4 | 23.1 | GO:0071459 | protein localization to chromosome, centromeric region(GO:0071459) |
| 0.7 | 21.6 | GO:0000470 | maturation of LSU-rRNA(GO:0000470) |
| 1.8 | 21.5 | GO:1901838 | positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838) |
| 0.3 | 19.5 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.5 | 19.2 | GO:0071425 | hematopoietic stem cell proliferation(GO:0071425) |
| 1.8 | 18.5 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 0.1 | 18.5 | GO:0016579 | protein deubiquitination(GO:0016579) |
| 0.1 | 18.2 | GO:0006397 | mRNA processing(GO:0006397) |
| 0.5 | 18.0 | GO:0033962 | cytoplasmic mRNA processing body assembly(GO:0033962) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 59.4 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 3.4 | 40.3 | GO:0000796 | condensin complex(GO:0000796) |
| 0.5 | 39.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 37.3 | GO:0005829 | cytosol(GO:0005829) |
| 0.0 | 26.9 | GO:0005730 | nucleolus(GO:0005730) |
| 1.5 | 22.7 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.5 | 20.8 | GO:0035869 | ciliary transition zone(GO:0035869) |
| 1.3 | 18.4 | GO:0005688 | U6 snRNP(GO:0005688) |
| 1.7 | 15.5 | GO:0001651 | dense fibrillar component(GO:0001651) |
| 0.7 | 15.0 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 31.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.5 | 22.0 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.2 | 21.5 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.2 | 20.6 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.4 | 18.7 | GO:0031369 | translation initiation factor binding(GO:0031369) |
| 0.1 | 16.8 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.2 | 16.0 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.3 | 15.6 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
| 2.2 | 15.5 | GO:0044547 | rRNA primary transcript binding(GO:0042134) DNA topoisomerase binding(GO:0044547) |
| 1.1 | 14.9 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 72.9 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.3 | 15.6 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.3 | 14.7 | PID ATR PATHWAY | ATR signaling pathway |
| 0.3 | 11.3 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.1 | 10.7 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 10.5 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.2 | 10.2 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.3 | 8.6 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 7.7 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 7.6 | PID MTOR 4PATHWAY | mTOR signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 83.0 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.3 | 34.1 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 1.0 | 22.7 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.6 | 19.4 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 0.1 | 16.7 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 1.5 | 14.7 | REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| 0.4 | 14.4 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.4 | 12.9 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.3 | 11.6 | REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS | Genes involved in Interactions of Vpr with host cellular proteins |
| 0.5 | 11.1 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |